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Dr Daniel Grint

Associate Professor

United Kingdom

I am a doctor of statistics and clinical trialist designing and leading on randomised controlled trials and observational studies in the field of tuberculosis (TB) and HIV.

Affiliations

Department of Infectious Disease Epidemiology and International Health
Faculty of Epidemiology and Population Health

Centres

TB Centre

Teaching

I co-organise the distance learning module EPM304 (Advanced Statistical Methods in Epidemiology). I also teach on the in-house courses Statistics for Epidemiology and Population Health (STEPH), Statistical Methods in Epidemiology (SME) and Advanced Statistical Methods in Epidemiology (ASME).

I tutor students on the MSc Epidemiology and MSc Medical Statistics intensive courses, as well as support distance learning students with their summer projects.

Research

I am a member of the International Statistics & Epidemiology Group (ISEG) and have links with the Electronic Health Records (EHR) group. My research focuses on the design, implementation, and analysis of randomised controlled trials, along with observational analysis of electronic health records.

My main research interest is the field of TB and HIV. I am the lead statistician on a trial assessing short-course high-dose rifampicin regimens for TB, and another assessing the effectiveness of injectable antiretroviral therapy for people living with HIV. I have a keen interest in the spectrum of TB disease and the impact that subclinical TB has on the burden of disease.

I serve on many Data Safety and Monitoring Boards (DSMB) for trials of new regimens for TB treatment as an independent statistician.

My recent work in the field of electronic health records focused on the COVID-19 pandemic, where working on behalf of NHS England I analysed data from UK general practice to test hypotheses in order to inform pandemic modelling studies.

Research Area
Applied statistics (medical)
Statistical methods
Epidemiology
Disease and Health Conditions
Tuberculosis
HIV/AIDS
COVID-19
Region
Sub-Saharan Africa (all income levels)
South Asia

Selected Publications

Four-Month High-Dose Rifampicin Regimens for Pulmonary Tuberculosis.
Jindani, A; Atwine, D; GRINT, D; Bah, B; Adams, J; Ticona, ER; Shrestha, B; Agizew, T; Hamid, S; Jamil, B; Byamukama, A; Kananura, K; Mugisha Taremwa, I; Bonnet, M; Camara, LM; Bah-Sow, OY; Bah, KS; Bah, NM; Sow, M; Ticona Huaroto, CE; Mugruza Pineda, R; Tandukar, B; Raya, BB; Shrestha, N; Mathoma, A; ... Harrison, TS.
2023
NEJM evidence
Accident and emergency (AE) attendance in England following infection with SARS-CoV-2 Omicron or Delta
GRINT, D; Wing, K; Gibbs, H; Evans, SJ W; Williamson, E; Bhaskaran, K; McDonald, H; Walker, A; Evans, D; Hickman, G; Mathur, R; Schultze, A; Rentsch, C; Tazare, J; Douglas, I; Curtis, H; Morton, C; Bacon, S; Davy, S; MacKenna, B; Inglesby, P; Croker, R; Parry, J; Hester, F; Harper, S; ... TOMLINSON, L.
2022
medRxiv
Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England.
GRINT, DJ; WING, K; Houlihan, C; Gibbs, HP; EVANS, SJ W; WILLIAMSON, E; MCDONALD, HI; BHASKARAN, K; Evans, D; Walker, AJ; Hickman, G; NIGHTINGALE, E; SCHULTZE, A; RENTSCH, CT; Bates, C; Cockburn, J; Curtis, HJ; Morton, CE; Bacon, S; Davy, S; WONG, AY S; Mehrkar, A; TOMLINSON, L; DOUGLAS, IJ; Mathur, R; ... EGGO, RM.
2021
Clinical infectious diseases
Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.
GRINT, DJ; WING, K; WILLIAMSON, E; MCDONALD, HI; BHASKARAN, K; Evans, D; EVANS, SJ; Walker, AJ; Hickman, G; NIGHTINGALE, E; SCHULTZE, A; RENTSCH, CT; Bates, C; Cockburn, J; Curtis, HJ; Morton, CE; Bacon, S; Davy, S; WONG, AY; Mehrkar, A; TOMLINSON, L; DOUGLAS, IJ; MATHUR, R; Blomquist, P; MacKenna, B; ... EGGO, RM.
2021
Eurosurveillance
High-Dose Oral and Intravenous Rifampicin for the Treatment of Tuberculous Meningitis in Predominantly Human Immunodeficiency Virus (HIV)-Positive Ugandan Adults: A Phase II Open-Label Randomized Controlled Trial.
CRESSWELL, FV; Meya, DB; Kagimu, E; GRINT, D; Te Brake, L; Kasibante, J; Martyn, E; Rutakingirwa, M; Quinn, CM; Okirwoth, M; Tugume, L; Ssembambulidde, K; Musubire, AK; Bangdiwala, AS; Buzibye, A; Muzoora, C; Svensson, EM; Aarnoutse, R; Boulware, DR; ELLIOTT, AM;
2021
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records
WALKER, JL; GRINT, DJ; STRONGMAN, H; EGGO, RM; Peppa, M; MINASSIAN, C; MANSFIELD, KE; RENTSCH, CT; DOUGLAS, IJ; MATHUR, R; WONG, AY S; Quint, JK; Andrews, N; Bernal, JL; SCOTT, JA; Ramsay, M; SMEETH, L; MCDONALD, H;
2020
MedRxiv
Safety of inadvertent administration of live zoster vaccine to immunosuppressed individuals in a UK-based observational cohort analysis.
GRINT, DJ; MCDONALD, HI; WALKER, JL; Amirthalingam, G; Andrews, N; Thomas, S;
2020
BMJ open
Risk score for predicting mortality including urine lipoarabinomannan detection in hospital inpatients with HIV-associated tuberculosis in sub-Saharan Africa: Derivation and external validation cohort study.
GUPTA-WRIGHT, A; CORBETT, EL; Wilson, D; Van Oosterhout, JJ; DHEDA, K; Huerga, H; Peter, J; Bonnet, M; Alufandika-Moyo, M; GRINT, D; LAWN, SD; FIELDING, K;
2019
PLoS medicine
Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa.
GRINT, D; Alisjhabana, B; Ugarte-Gil, C; Riza, A-L; Walzl, G; Pearson, F; Ruslami, R; MOORE, DA J; Ioana, M; McAllister, S; Ronacher, K; Koeseomadinata, RC; Kerry-Barnard, SR; Coronel, J; Malherbe, ST; DOCKRELL, HM; Hill, PC; Van Crevel, R; Critchley, JA; TANDEM consortium,;
2018
Bulletin of the World Health Organization
Rapid urine-based screening for tuberculosis in HIV-positive patients admitted to hospital in Africa (STAMP): a pragmatic, multicentre, parallel-group, double-blind, randomised controlled trial.
GUPTA-WRIGHT, A; CORBETT, EL; Van Oosterhout, JJ; Wilson, D; GRINT, D; Alufandika-Moyo, M; Peters, JA; Chiume, L; FLACH, C; Lawn, SD; FIELDING, K;
2018
LANCET
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