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Dr Daniel Grint

BSc MSc PhD

Assistant Professor
of Medical Statistics & Epidemiology

Room
G12

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
x4818

Affiliations

Department of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health

Centres

Statistical Methodology
Tuberculosis (TB) Centre
Vaccine Centre

Teaching

I co-organise (with Sian Floyd) the distance learning module EPM304 (Advanced Statistical Methods in Epidemiology). I also teach on the in-house courses Statistics for Epidemiology and Population Health (STEPH), Statistical Methods in Epidemiology (SME) and Advanced Statistical Methods in Epidemiology (ASME).

Research

I am a member of the Tropical Epidemiology Group (TEG) and Health Protection Research Unit (HRPU) in Immunisation. My research focuses on the design, implementation and analysis of randomised clnical trials, along with analysis of electronic health records.

I am the trial statistician on the RIFASHORT trial. This trial with sites in Botswana, Uganda, Guinea, Peru, and Nepal aims to assess the efficacy and saftey of 4-month high-dose rifampicin treatment regimens for TB. I am also statistical adviser and co-supervisor to Fiona Cresswell on the RIFT trial. This trial aims to assess the safety of high-dose oral and intravenous rifampicin for treatment of TB meningitis in Uganda.

I serve as an independant statistician on the Data Safety and Monitoring Boards (DSMB) for two trials of TB treatment. The SIMPLICITB and BEAT TB trials are both assessing the efficacy and safety of 6-month regimens for treatment of drug-resistant TB.

I am analysing electronic health record data from UK GP practices to describe vaccine uptake, effectiveness, and adverse outcomes.

Research Area
Diagnostics
Statistical methods
Vaccines
Electronic health records
Immunisation
Pharmacokinetics
Randomised controlled trials
Discipline
Epidemiology
Statistics
Disease and Health Conditions
HIV/AIDS
Infectious disease
Tuberculosis
Diabetes
Hepatitis
Region
European Union
Latin America & Caribbean (all income levels)
Sub-Saharan Africa (all income levels)

Selected Publications

Risk score for predicting mortality including urine lipoarabinomannan detection in hospital inpatients with HIV-associated tuberculosis in sub-Saharan Africa: Derivation and external validation cohort study.
Gupta-Wright A; Corbett EL; Wilson D; van Oosterhout JJ; Dheda K; Huerga H; Peter J; Bonnet M; Alufandika-Moyo M; Grint D
2019
PLoS medicine
Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries.
Huangfu P; Laurence YV; Alisjahbana B; Ugarte-Gil C; Riza A-L; Walzl G; Ruslami R; Moore DAJ; Ioana M; McAllister S
2019
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Rapid urine-based screening for tuberculosis in HIV-positive patients admitted to hospital in Africa (STAMP): a pragmatic, multicentre, parallel-group, double-blind, randomised controlled trial
Gupta-Wright A; Corbett EL; van Oosterhout JJ; Wilson D; Grint D; Alufandika-Moyo M; Peters JA; Chiume L; Flach C; Lawn SD
2018
LANCET
High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study).
Cresswell FV; Ssebambulidde K; Grint D; Te Brake L; Musabire A; Atherton RR; Tugume L; Muzoora C; Lukande R; Lamorde M
2018
Wellcome open research
Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa.
Grint D; Alisjhabana B; Ugarte-Gil C; Riza A-L; Walzl G; Pearson F; Ruslami R; Moore DAJ; Ioana M; McAllister S
2018
Bulletin of the World Health Organization
Liver-related death among HIV/hepatitis C virus-co-infected individuals: implications for the era of directly acting antivirals.
Grint D; Peters L; Rockstroh JK; Rakmanova A; Trofimova T; Lacombe K; Karpov I; Galli M; Domingo P; Kirk O
2015
AIDS (London, England)
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