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Dr Daniel Grint

BSc MSc PhD

Assistant Professor
of Medical Statistics & Epidemiology

Room
G12

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
x4818
Jump to: Affiliations Teaching Research Publications

Affiliations
Department of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health

Centres

Centre for Statistical Methodology
TB Centre

Teaching

I co-organise (with Sian Floyd) the distance learning module EPM304 (Advanced Statistical Methods in Epidemiology). I also teach on the in-house courses Statistics for Epidemiology and Population Health (STEPH), Statistical Methods in Epidemiology (SME) and Advanced Statistical Methods in Epidemiology (ASME).

Research

I am a member of the International Statistics & Epidemiology Group (ISEG) and am also currently working with the OpenSafely group. My research focuses on the design, implementation and analysis of randomised clinical trials, along with analysis of electronic health records.

I am the trial statistician on the RIFASHORT trial. This trial with sites in Botswana, Uganda, Guinea, Peru, Nepal, and Pakistan aims to assess the efficacy and saftey of 4-month high-dose rifampicin treatment regimens for TB. I am statistical adviser and co-supervisor to Fiona Cresswell on the RIFT trial. This trial aims to assess the safety of high-dose oral and intravenous rifampicin for treatment of TB meningitis in Uganda.

I serve as an independant statistician on the Data Safety and Monitoring Boards (DSMB) for two trials of TB treatment. The SIMPLICITB and BEAT TB trials are both assessing the efficacy and safety of 6-month regimens for treatment of drug-resistant TB.

I am analysing electronic health record data from UK general practices to test hypotheses relating to COVID-19 and inform pandemic modelling studies.

Research Area
Diagnostics
Statistical methods
Vaccines
Electronic health records
Immunisation
Pharmacokinetics
Randomised controlled trials
Discipline
Epidemiology
Statistics
Disease and Health Conditions
HIV/AIDS
Infectious disease
Tuberculosis
Diabetes
Hepatitis
Region
European Union
Latin America & Caribbean (all income levels)
Sub-Saharan Africa (all income levels)

Selected Publications
Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study.
Cresswell FV; Tugume L; Bahr NC; Kwizera R; Bangdiwala AS; Musubire AK; Rutakingirwa M; Kagimu E; Nuwagira E; Mpoza E
2020
The Lancet. Infectious diseases
Safety of inadvertent administration of live zoster vaccine to immunosuppressed individuals in a UK-based observational cohort analysis.
Grint DJ; McDonald HI; Walker JL; Amirthalingam G; Andrews N; Thomas S
2020
BMJ open
Virological failure, HIV-1 drug resistance, and early mortality in adults admitted to hospital in Malawi: an observational cohort study.
Gupta-Wright A; Fielding K; van Oosterhout JJ; Alufandika M; Grint DJ; Chimbayo E; Heaney J; Byott M; Nastouli E; Mwandumba HC
2020
The lancet. HIV
UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records
Walker J; Grint D; Strongman H; Eggo R; Peppa M; Minassian C; Mansfield K; Rentsch C; Douglas I; Mathur R
2020
Risk score for predicting mortality including urine lipoarabinomannan detection in hospital inpatients with HIV-associated tuberculosis in sub-Saharan Africa: Derivation and external validation cohort study.
Gupta-Wright A; Corbett EL; Wilson D; van Oosterhout JJ; Dheda K; Huerga H; Peter J; Bonnet M; Alufandika-Moyo M; Grint D
2019
PLoS medicine
Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries.
Huangfu P; Laurence YV; Alisjahbana B; Ugarte-Gil C; Riza A-L; Walzl G; Ruslami R; Moore DAJ; Ioana M; McAllister S
2019
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study).
Cresswell FV; Ssebambulidde K; Grint D; Te Brake L; Musabire A; Atherton RR; Tugume L; Muzoora C; Lukande R; Lamorde M
2018
Wellcome open research
Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa.
Grint D; Alisjhabana B; Ugarte-Gil C; Riza A-L; Walzl G; Pearson F; Ruslami R; Moore DAJ; Ioana M; McAllister S
2018
Bulletin of the World Health Organization
Rapid urine-based screening for tuberculosis in HIV-positive patients admitted to hospital in Africa (STAMP): a pragmatic, multicentre, parallel-group, double-blind, randomised controlled trial.
Gupta-Wright A; Corbett EL; van Oosterhout JJ; Wilson D; Grint D; Alufandika-Moyo M; Peters JA; Chiume L; Flach C; Lawn SD
2018
LANCET
Liver-related death among HIV/hepatitis C virus-co-infected individuals: implications for the era of directly acting antivirals.
Grint D; Peters L; Rockstroh JK; Rakmanova A; Trofimova T; Lacombe K; Karpov I; Galli M; Domingo P; Kirk O
2015
AIDS (London, England)
See more Publications

Contact

Room
G12

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
x4818