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Prof Alison Grant

Dean of Faculty & Prof of Intern Health

United Kingdom

I trained initially as a physician specialising in infectious and tropical diseases and HIV medicine, and continue to work as an HIV doctor in London. I studied epidemiology at LSHTM with particular interests in care for people with HIV in developing countries.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Centre for Evaluation
TB Centre
Antimicrobial Resistance Centre

Teaching

My main areas of teaching are epidemiology, research skills, HIV medicine and TB, particularly to students on MSc Tropical Medicine and International Health, and the LSHTM Diplomas in Tropical Medicine and Hygiene. Teaching is largely on pause while I'm Dean of Faculty.

Research

My main research interest is improving care for people with HIV in high prevalence countries, and preventing TB. Major projects have included a cluster-randomised trial investigating a point-of-care TB test and treat algorithm for people with advanced HIV disease in South Africa; evaluation of South African national roll-out of Xpert MTB/RIF, a new TB diagnostic test replacing smear microscopy; investigation of how best to use Xpert MTB/RIF among people attending clinics for HIV care; linkage to care after a rifampicin-resistant Xpert MTB/RIF result in South Africa; and a trial comparing a single round of weekly isoniazid/rifapentine to periodic treatment. In collaboration with colleagues in South Africa, I have been involved with the design, implementation and evaluation of an HIV care programme in workplace and community settings.

I am a faculty member at the Africa Health Research Institute, KwaZulu-Natal, South Africa where projects have included a programme taking a whole systems approach to TB infection prevention and control in primary healthcare clinics in South Africa (Umoya omuhle); investigating thoracic ultrasound as a diagnostic modality for pulmonary TB; a study investigating the infectiousness of people with subclinical vs clinical TB, and a study investigating potential predictive biomarkers of TB.
Research Area
Epidemiology
Public health
Clinical trials
Implementation science
Clinical research
Disease and Health Conditions
Tuberculosis
HIV/AIDS
Country
South Africa
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Modelling the effect of infection prevention and control measures on rate of Mycobacterium tuberculosis transmission to clinic attendees in primary health clinics in South Africa.
MCCREESH, N; Karat, AS; BAISLEY, K; Diaconu, K; BOZZANI, F; GOVENDER, I; Beckwith, P; Yates, TA; Deol, AK; HOUBEN, RM G J; Kielmann, K; WHITE, RG; GRANT, AD;
2021
BMJ global health
Algorithm-guided empirical tuberculosis treatment for people with advanced HIV (TB Fast Track): an open-label, cluster-randomised trial.
GRANT, AD; CHARALAMBOUS, S; Tlali, M; KARAT, AS; Dorman, SE; Hoffmann, CJ; Johnson, S; VASSALL, A; CHURCHYARD, GJ; FIELDING, KL;
2019
The Lancet HIV
Measuring income for catastrophic cost estimates: Limitations and policy implications of current approaches.
SWEENEY, S; Mukora, R; Candfield, S; GUINNESS, L; GRANT, AD; VASSALL, A;
2018
Social science & medicine (1982)
Performance of verbal autopsy methods in estimating HIV-associated mortality among adults in South Africa.
KARAT, AS; Maraba, N; Tlali, M; Charalambous, S; Chihota, VN; CHURCHYARD, GJ; FIELDING, KL; Hanifa, Y; Johnson, S; McCarthy, KM; Kahn, K; CHANDRAMOHAN, D; GRANT, AD;
2018
BMJ global health
Cost-effectiveness of Xpert MTB/RIF for tuberculosis diagnosis in South Africa: a real-world cost analysis and economic evaluation.
VASSALL, A; SIAPKA, M; FOSTER, N; Cunnama, L; Ramma, L; FIELDING, K; McCarthy, K; CHURCHYARD, G; GRANT, A; Sinanovic, E;
2017
The Lancet Global health
Delays and loss to follow-up before treatment of drug-resistant tuberculosis following implementation of Xpert MTB/RIF in South Africa: A retrospective cohort study.
Cox, H; Dickson-Hall, L; Ndjeka, N; Van't Hoog, A; GRANT, A; Cobelens, F; Stevens, W; Nicol, M;
2017
PLoS medicine
Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF.
CHURCHYARD, GJ; Stevens, WS; Mametja, LD; McCarthy, KM; Chihota, V; Nicol, MP; Erasmus, LK; Ndjeka, NO; Mvusi, L; VASSALL, A; Sinanovic, E; Cox, HS; Dye, C; GRANT, AD; FIELDING, KL;
2015
The Lancet Global health
Ability of preventive therapy to cure latent Mycobacterium tuberculosis infection in HIV-infected individuals in high-burden settings.
HOUBEN, RM G J; SUMNER, T; GRANT, AD; WHITE, RG;
2014
Proceedings of the National Academy of Sciences of the United States of America
A trial of mass isoniazid preventive therapy for tuberculosis control.
CHURCHYARD, GJ; FIELDING, KL; LEWIS, JJ; Coetzee, L; CORBETT, EL; GODFREY-FAUSSETT, P; HAYES, RJ; Chaisson, RE; GRANT, AD; Thibela TB Study Team,;
2014
The New England journal of medicine
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