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Alison Grant

MBBS MSc PhD DTM&H

Professor
of International Health

Room
Room 301

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 20 7927 2304

Fax.
+44 20 7927 2739

I trained initially as a physician specialising in infectious and tropical diseases and HIV medicine, and continue to work in HIV medicine in London. I studied epidemiology at LSHTM with particular interests in care for people with HIV in developing countries.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Centre for Evaluation
Tuberculosis (TB) Centre

Teaching

I teach epidemiology, HIV medicine, TB and clinical tropical medicine, particularly to students on MSc Tropical Medicine and International Health, and the LSHTM Diplomas in Tropical Medicine and Hygiene (in London and in East Africa).

Research

My main research interest is improving care for people with HIV in developing countries, and preventing TB. Major projects include a cluster randomised trial investigating a point-of-care TB test and treat algorithm for people with advanced HIV disease in South Africa; evaluation of South African national roll-out of Xpert MTB/RIF, a new TB diagnostic test replacing smear microscopy; investigation of how best to use Xpert MTB/RIF among people attending clinics for HIV care; linkage to care after a rifampicin-resistant Xpert MTB/RIF result in South Africa; and a trial comparing a single round of weekly isoniazid/rifapentine to periodic treatment. In collaboration with colleagues in South Africa, I have been involved with the design, implementation and evaluation of an HIV care programme in workplace and community settings.

As the programme lead, I am developing a programme of tuberculosis research at the Africa Centre, KwaZulu-Natal, South Africa.

I supervise research degree students working on use of Xpert MTB/RIF in South Africa and Botswana; causes of death among people starting ART in South Africa; and pathways to TB care in Ghana.

Research Area
Clinical care
Clinical trials
Evaluation
Implementation research
Randomised controlled trials
Discipline
Epidemiology
Medicine
Operational research
Disease and Health Conditions
HIV/AIDS
Infectious disease
Tuberculosis
Country
United Kingdom
South Africa
Region
Europe & Central Asia (all income levels)
Sub-Saharan Africa (all income levels)

Selected Publications

Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF.
Churchyard, G.J. ; Stevens, W.S. ; Mametja, L.D. ; McCarthy, K.M. ; Chihota, V. ; Nicol, M.P. ; Erasmus, L.K. ; Ndjeka, N.O. ; Mvusi, L. ; Vassall, A. ; Sinanovic, E. ; Cox, H.S. ; Dye, C. ; Grant, A.D. ; Fielding, K.L. ;
Lancet Glob Health
Viral suppression following switch to second-line antiretroviral therapy: associations with NRTI resistance and 'sub-therapeutic' drug concentrations prior to switch.
Johnston, V.; Cohen, K.; Wiesner, L.; Morris, L.; Ledwaba, J.; Fielding, K.L.; Charalambous, S.; Churchyard, G.; Phillips, A.; Grant, A.D.;
J Infect Dis
A trial of mass isoniazid preventive therapy for tuberculosis control.
Churchyard, G.J. ; Fielding, K.L. ; Lewis, J.J. ; Coetzee, L. ; Corbett, E.L. ; Godfrey-Faussett, P. ; Hayes, R.J. ; Chaisson, R.E. ; Grant, A.D. ; Thibela TB Study Team, . ;
N Engl J Med
Development of a Standardized Screening Rule for Tuberculosis in People Living with HIV in Resource-Constrained Settings: Individual Participant Data Meta-analysis of Observational Studies
Getahun, H.; Kittikraisak, W.; Heilig, C.M.; Corbett, E.L.; Ayles, H.; Cain, K.P.; Grant, A.D.; Churchyard, G.J.; Kimerling, M.; Shah, S.; Lawn, S.D.; Wood, R.; Maartens, G.; Granich, R.; Date, A.A.; Varma, J.K.
Plos Medicine
Tuberculosis among people with HIV infection in the United Kingdom: opportunities for prevention?
Grant, A.D.; Bansi, L.; Ainsworth, J.; Anderson, J.; Delpech, V.; Easterbrook, P.; Fisher, M.; Gazzard, B.; Gilson, R.; Gompels, M.; Hill, T.; Johnson, M.; Leen, C.; Orkin, C.; Phillips, A.N.; Porter, K.; Post, F.; Walsh, J.; Sabin, C.A.; United Kingdom Collaborative HIV Cohort Study Group, .;
AIDS
Evaluation of the WHO criteria for antiretroviral treatment failure among adults in South Africa.
Mee, P.; Fielding, K.L.; Charalambous, S.; Churchyard, G.J.; Grant, A.D.;
AIDS
Isoniazid preventive therapy and risk for resistant tuberculosis.
Balcells, M.E.; Thomas, S.L.; Godfrey-Faussett, P.; Grant, A.D.;
Emerg Infect Dis
Effect of routine isoniazid preventive therapy on tuberculosis incidence among HIV-infected men in South Africa: a novel randomized incremental recruitment study.
Grant, A.D.; Charalambous, S.; Fielding, K.L.; Day, J.H.; Corbett, E.L.; Chaisson, R.E.; De Cock, K.M.; Hayes, R.J.; Churchyard, G.J.;
JAMA
See all Alison Grant's Publications