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Dr Aline Freville

Research Fellow

United Kingdom

I am a Research Fellow in Prof David Baker's laboratory. We use molecular and biochemical methodologies to understand the role of cyclic nucleotide signalling in regulating the malaria parasite (Plasmodium falciparum) life cycle.

Before assuming my current role, I served as a Research Fellow in the laboratories of Dr. Christiaan van Ooij (2021-2023) and Prof. David Conway (2019-2021).

As a research fellow in the van Ooij lab, my research centered on elucidating the impact of PV6, a phospholipid transfer protein, on the asexual development of Plasmodium falciparum. We utilized the DiCre conditional gene knock-down system to investigate the protein's influence on the expansion of the parasite parasitophorous vacuole membrane and the development of young Plasmodium falciparum forms.

As a research fellow in the Conway lab, my research focused on understanding the variability in sexual conversion among Plasmodium falciparum isolates, particularly in response to environmental conditions, providing insights into factors affecting the parasite's lifecycle and transmission dynamics.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre

Teaching

Since January 2024, I work as a tutor for the IDM503 "Malaria" and IDM102 "Principles of Biology" distance learning modules (marking of assignments). Additionally, I conduct online lectures for the IDM102 module.

I supervise Master's summer students and visiting PhD scholars.

Research

Research Area
Parasitology
Cell biology
Molecular biology
Biochemistry
Microbiology
Protozoa
Disease and Health Conditions
Malaria
Country
United Kingdom

Selected Publications

Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but may not be linked to sexual commitment.
FREVILLE, A; Stewart, L; Tetteh, K; Treeck, M; Cortes, A; Voss, T; Tarr, S; Baker, D; Conway, D;
2024
2024_Malaria Retreat
Expression of the MSPDBL2 antigen in a discrete subset of <i>Plasmodium falciparum</i> schizonts is regulated by GDV1 but may not be linked to sexual commitment.
FREVILLE, A; Stewart, LB; Tetteh, KK A; Treeck, M; Cortes, A; Voss, TS; Tarr, SJ; BAKER, DA; CONWAY, DJ;
2024
mBio
Expression of the MSPDBL2 antigen in a discrete subset of<i>Plasmodium falciparum</i>schizonts is regulated by GDV1 but not linked to sexual commitment
FREVILLE, A; Stewart, L; Tetteh, KK A; Treeck, M; Cortes, A; Voss, T; Tarr, S; Baker, D; CONWAY, D;
2023
bioRxiv
Plasmodium falciparum Sexual Commitment Rate Variation among Clinical Isolates and Diverse Laboratory-Adapted Lines.
STEWART, LB; FREVILLE, A; Voss, TS; BAKER, DA; Awandare, GA; CONWAY, DJ;
2022
Microbiology spectrum
PV6: A Plasmodium protein required for expansion of the parasitophorous vacuole membrane
FREVILLE, A; Moreira-Leite, F; Vaughan, S; Russell, M; Collinson, L; Blackman, MJ; Van Ooij, C;
2022
Molecular Parasitology Meeting XXXIII
Highly Variable Expression of Merozoite Surface Protein MSPDBL2 in Diverse Plasmodium falciparum Clinical Isolates and Transcriptome Scans for Correlating Genes.
Hocking, SE; STEWART, LB; FREVILLE, A; Reid, AJ; Tarr, SJ; TETTEH, KK A; Flueck, C; Ahouidi, AD; AMAMBUA-NGWA, A; Diakite, M; Awandare, GA; CONWAY, DJ;
2022
mBio
Plasmodium berghei leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development.
Fréville, A; Gnangnon, B; TREMP, AZ; De Witte, C; Cailliau, K; Martoriati, A; Aliouat, EM; Fernandes, P; Chhuon, C; Silvie, O; Marion, S; Guerrera, IC; DESSENS, JT; Pierrot, C; Khalife, J;
2022
Open Biology
Transcriptome analysis of diverse <i>Plasmodium falciparum</i> clinical isolates identifies genes correlating with highly variable expression of merozoite surface protein MSPDBL2
Hocking, S; Stewart, L; Tarr, S; FREVILLE, A; Tetteh, K; Ahouidi, A; Amambua-Ngwa, A; Diakite, M; Awandare, G; CONWAY, D;
2022
bioRxiv
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