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Prof Stefan Flasche

Professor of Vaccine Epidemiology

United Kingdom

Since my PhD years I have been fascinated by the complexities and challenges of pneumococcal vaccination which has been one of my my main

foci of work. My research in this area is currently supported through a Sir Henry Dale Wellcome Trust Fellowship alongside other research

grants.

I have also been frequently following related interest, e.g. outbreak response (SARS-CoV-2, ebola and swine flu), antimicrobial resistance, vector bourne disease (dengue and malaria) and health in humanitarian crises.

I currently am co-director of CMMID, a member of WHO's IVIR-AC and serve on a WHO SAGE's working groups on pneumococcal conjugate vaccines and on COVID19 vaccines. I also serve on the Joint Committee on Vaccination and Immunisation's (JCVI) pneumococcal subgroup.

Affiliations

Department of Infectious Disease Epidemiology and Dynamics
Faculty of Epidemiology and Population Health

Centres

Centre for Data and Statistical Science for Health
Centre for Mathematical Modelling of Infectious Diseases
Vaccine Centre
Antimicrobial Resistance Centre

Teaching

I teach on the modelling short course and the MSc module, on STEPH and ECCD and I co-organise and teach on the short course on epidemiological evaluation of vaccines. I supervise one to three Master student summer projects each year and a number of PhD projects; please get in touch if this is of interest to you.

Research

My main research area is the evaluation and optimisation of vaccine interventions. For S. pneumoniae this includes using mathematical models to help better understand how to use existing pneumococcal vaccine more efficiently, ie reducing cost and maximising impact, and to help designing optimal future vaccine formulations. 

My team and I work closely with a range of international partners including on vaccine trials and their interpretation in Vietnam and in humanitarian crises settings. My other interests include real-time evaluation of pandemic pathogens  as well as evolution and mitigation of AMR, assessing and

predicting the impact of vaccines against seasonal influenza, HiB, varicella zoster, melioidosis, non-typhoid salmonella, RSV, hand foot and mouth disease, malaria and dengue.

Selected Publications

The effectiveness of social bubbles as part of a Covid-19 lockdown exit strategy, a modelling study
Leng, T; White, C; Hilton, J; KUCHARSKI, A; Pellis, L; Stage, H; DAVIES, NG; Keeling, MJ; FLASCHE, S;
2021
Wellcome Open Research
The impact of population-wide rapid antigen testing on SARS-CoV-2 prevalence in Slovakia.
PAVELKA, M; Van-Zandvoort, K; ABBOTT, S; SHERRATT, K; Majdan, M; CMMID COVID-19 working group,; Inštitút Zdravotných Analýz,; Jarčuška, P; Krajčí, M; FLASCHE, S; FUNK, S;
2021
Science (New York, N.Y.)
Efficacy of live oral rotavirus vaccines by duration of follow-up: a meta-regression of randomised controlled trials.
CLARK, A; VAN ZANDVOORT, K; FLASCHE, S; SANDERSON, C; Bines, J; Tate, J; Parashar, U; JIT, M;
2019
LANCET INFECTIOUS DISEASES
Sensitivity and negative predictive value for a rapid dengue test.
FLASCHE, S; SMITH, PG;
2019
The Lancet. Infectious diseases
Sustaining pneumococcal vaccination after transitioning from Gavi support: a modelling and cost-effectiveness study in Kenya.
OJAL, J; Griffiths, U; Hammitt, LL; ADETIFA, I; Akech, D; Tabu, C; SCOTT, JA G; FLASCHE, S;
2019
The Lancet Global Health
Within-host dynamics shape antibiotic resistance in commensal bacteria.
DAVIES, NG; FLASCHE, S; JIT, M; ATKINS, KE;
2019
Nature ecology & evolution
Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine.
WILDER-SMITH, A; Hombach, J; Ferguson, N; Selgelid, M; O'Brien, K; Vannice, K; Barrett, A; Ferdinand, E; FLASCHE, S; Guzman, M; Novaes, HM; Ng, L-C; SMITH, PG; Tharmaphornpilas, P; Yoon, I-K; Cravioto, A; Farrar, J; Nolan, TM;
2018
The Lancet infectious diseases
Balancing Benefits and Risks of Antibiotic Use.
FLASCHE, S; ATKINS, KE;
2018
The Journal of infectious diseases
Pre-vaccination carriage prevalence of Streptococcus pneumoniae serotypes among internally displaced people in Somaliland
VAN ZANDVOORT, K; Ibrahim Hassan, A; Bobe, M; Pell, C; Ahmed, MS; Ortika, B; Ibrahim, S; Abdi, MI; Karim, M; EGGO, R; Yusuf, S; Hinds, J; Soleman, SM; Cummings, R; MCGOWAN, C; Mulholland, K; Hergeeye, MA; Satzke, C; CHECCHI, F; FLASCHE, S;
2024
medRxiv
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