of Vaccine Epidemiology & co-director of CMMID
Since my PhD years I have been fascinated by the complexities and challenges of pneumococcal vaccination which has been my main focus of work. As of 2018 my research in this area is supported through a Sir Henry Dale Wellcome Trust Fellowship.
I have also been frequently following related interest, in particular for outbreak response (SARS-CoV-2, ebola and swine flu) and adivising WHO on modelling (including dengue and malaria).
I currently am co-director of CMMID, serve on WHO's Strategic Advisory Group of Experts on Immunisation's (WHO SAGE) working group on pneumococcal conjugate vaccines and on the WHO SAGE working group on dengue vaccine as well on the Joint Committee on Vaccination and Immunisation's (JCVI) pneumococcal subgroup.
I teach on the modelling short course and the MSc module, on STEPH and ECCD and I co-organise and teach on the short course on epidemiological evaluation of vaccines. I supervise two to three Master student summer projects each year and a number of PhD projects (I am currently unable to take on any more PhD students).
My main research area is the evaluation and optimisation of vaccine interventions for S. pneumoniae through mathematical models. Despite the success of pneumococcal vaccines in substantially reducing the pneumococcal disease burden worldwide serotype replacement has mitigated potentially larger impact.
My team and I work with local and international collaborators to help better understand how to use existing pneumococcal vaccine more efficiently, ie reducing cost and maximising impact, and to help designing optimal future vaccine formulations.
We work closely with a range of international partners including on vaccine trials and their interpretation in Vietnam and in humanitarian crises settings.
My other interests include real-time evaluation of pandemic pathogens as well as assessing and predicting the impact of vaccines against seasonal influenza, HiB, varicella zoster, melioidosis, non-typhoid salmonella, RSV, hand foot and mouth disease, malaria and dengue.