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Stefan Flasche

PhD

Professor
of Vaccine Epidemiology & co-director of CMMID

Room
104A

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7958 8272

Since my PhD years I have been fascinated by the complexities and challenges of pneumococcal vaccination which has been one of my my main foci of work. My research in this area is currently supported through a Sir Henry Dale Wellcome Trust Fellowship alongside other research grants.

I have also been frequently following related interest, e.g. outbreak response (SARS-CoV-2, ebola and swine flu), antimicrobial resistance, vector bourne disease (dengue and malaria) and health in humanitarian crises.

I currently am co-director of CMMID, a member of WHO's IVIR-AC, co-chair of WHO SAGE'S COVID19 vaccine modelling subgroup and serve on a WHO SAGE's working groups on pneumococcal conjugate vaccines, on dengue vaccines and on COVID19 vaccines. I also serve on the Joint Committee on Vaccination and Immunisation's (JCVI) pneumococcal subgroup.

Affiliations

Faculty of Epidemiology and Population Health
Department of Infectious Disease Epidemiology

Centres

Centre for Mathematical Modelling of Infectious Diseases (CMMID)
Vaccine Centre

Teaching

I teach on the modelling short course and the MSc module, on STEPH and ECCD and I co-organise and teach on the short course on epidemiological evaluation of vaccines. I supervise two to three Master student summer projects each year and a number of PhD projects (I am currently unable to take on any more PhD students).  

Research

My main research area is the evaluation and optimisation of vaccine interventions. For S. pneumoniae this includes using mathematical models to help better understand how to use existing pneumococcal vaccine more efficiently, ie reducing cost and maximising impact, and to help designing optimal future vaccine formulations. 

My team and I work closely with a range of international partners including on vaccine trials and their interpretation in Vietnam and in humanitarian crises settings.

My other interests include real-time evaluation of pandemic pathogens  as well as evolution and mitigation of AMR, assessing and predicting the impact of vaccines against seasonal influenza, HiB, varicella zoster, melioidosis, non-typhoid salmonella, RSV, hand foot and mouth disease, malaria and dengue.

Research Area
Child health
Economic evaluation
Infectious disease policy
Public health
Vaccines
Bayesian Analysis
Disease control
Global Health
Immunisation
Outbreaks
Modelling
Discipline
Epidemiology
Mathematical modelling
Disease and Health Conditions
Infectious disease
Meningitis
Pandemic diseases
Emerging Infectious Disease
Influenza
Respiratory disease
Region
World

Selected Publications

The effectiveness of social bubbles as part of a Covid-19 lockdown exit strategy, a modelling study
Leng T; White C; Hilton J; Kucharski A; Pellis L; Stage H; Davies NG; Keeling MJ; Flasche S
2021
Wellcome Open Research
The impact of population-wide rapid antigen testing on SARS-CoV-2 prevalence in Slovakia.
Pavelka M; Van-Zandvoort K; Abbott S; Sherratt K; Majdan M; CMMID COVID-19 working group; Inštitút Zdravotných Analýz; Jarčuška P; Krajčí M; Flasche S
2021
Science (New York, N.Y.)
Efficacy of live oral rotavirus vaccines by duration of follow-up: a meta-regression of randomised controlled trials.
Clark A; van Zandvoort K; Flasche S; Sanderson C; Bines J; Tate J; Parashar U; Jit M
2019
LANCET INFECTIOUS DISEASES
Within-host dynamics shape antibiotic resistance in commensal bacteria.
Davies NG; Flasche S; Jit M; Atkins KE
2019
Nature ecology & evolution
Sensitivity and negative predictive value for a rapid dengue test.
Flasche S; Smith PG
2019
The Lancet. Infectious diseases
Sustaining pneumococcal vaccination after transitioning from Gavi support: a modelling and cost-effectiveness study in Kenya.
Ojal J; Griffiths U; Hammitt LL; Adetifa I; Akech D; Tabu C; Scott JAG; Flasche S
2019
The Lancet Global Health
Balancing Benefits and Risks of Antibiotic Use.
Flasche S; Atkins KE
2018
The Journal of infectious diseases
Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine.
Wilder-Smith A; Hombach J; Ferguson N; Selgelid M; O'Brien K; Vannice K; Barrett A; Ferdinand E; Flasche S; Guzman M
2018
The Lancet infectious diseases
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