Dr Stefan Flasche
of Vaccine Epidemiology
I have a diploma (masters equivalent) in mathematics from the Technische Universitaet in Berlin and did my PhD in mathematical modelling of infectious diseases with Strathclyde University and Public Health England. Since my PhD years I have been fascinated by the complexities and challenges of pneumococcal vaccination which has been my main focus of work. As of 2018 my research in this area is funded through a Sir Henry Dale Wellcome Trust Fellowship.
I have also been frequently following related interest, in particular for outbreak response (swine flu and ebola) and adivising WHO on modelling (including dengue and malaria). I currently serve on WHO's Strategic Advisory Group of Experts on Immunisation's (WHO SAGE) working group on pneumococcal conjugate vaccines and on the WHO SAGE working group on dengue vaccine as well on the Joint Committee on Vaccination and Immunisation's (JCVI) pneumococcal subgroup.
I teach on the modelling short course and the MSc module, on STEPH and ECCD and I co-organise and teach on the short course on epidemiological evaluation of vaccines. I supervise two to three Master student summer projects each year and a number of PhD projects (I am currently unable to take on any more PhD students).
My main research area is the evaluation and optimisation of vaccine interventions for S. pneumoniae through mathematical models. Despite the success of pneumococcal vaccines in substantially reducing the pneumococcal disease burden worldwide serotype replacement has mitigated potentially larger impact. I work with local and international collaborators to help better understand how to use existing pneumococcal vaccine more efficiently, ie reducing cost and maximising impact, and to help designing optimal future vaccine formulations.
My other interests include real-time evaluation of pandemic flu and ebola during outbreak situations as well as assessing and predicting the impact of vaccines against seasonal influenza, HiB, varicella zoster, melioidosis, non-typhoid salmonella, RSV, hand foot and mouth disease, malaria and dengue.