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Professor Nick Dorrell

BPharmHons MRPharmS PhD FHEA

Professor
of Bacterial Pathogenesis and Faculty Taught Programme Director

Room
Room 382

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7927 2838

Fax.
020 7927 2131

Nick Dorrell originally trained as a pharmacist, obtaining a Bachelor of Pharmacy degree from the University of Bath in 1988 and completing his pre-registration training at King's College Hospital in 1989. After two years working in hospital pharmacy, he returned to Bath to study DNA repair in Escherichia coli, completing his PhD in 1993. He joined Brendan Wren's research group at St Bartholomew's Hospital in January 1994, working on many different aspects of bacterial pathogenicity of Brucella species, Yersinia species and Helicobacter pylori. He joined the LSHTM in July 1999 and is continuing to study the pathogenicity of both H. pylori and predominantly Campylobacter jejuni.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Pathogen Molecular Biology

Teaching

In September 2016, Nick has taken on the role of Taught Programme Director for the Faculty of Infectious & Tropical Diseases, with oversight of teaching on all the MSc Programmes, Short Courses and Taught Modules run by the Faculty. Previously Nick was the Course Director for the MSc in Medical Microbiology (https://www.lshtm.ac.uk/study/masters/medical-microbiology) from 2005 to 2016. During this time, he also acted as Module Organiser for the MSc Modules on Core Bacteriology, Clinical Bacteriology and Clinical Virology and also lectured on the MSc Module Advanced Training in Molecular Biology. He chaired the Course Committee and was a member of the Exam Board for the MSc in Medical Microbiology.

Nick currently supervises three PhD students and also supervises MSc research projects at the LSHTM.

Nick successfully completed the Professional Certificate in Teaching and Learning in Higher and Professional Education (with Distinction) at the Institute of Education (University of London) in 2006 and became a Fellow of The Higher Education Academy in 2007.

Research

Current research interests cover five main areas of bacterial pathogenesis:-

  • Role of outer membrane vesicles during C. jejuni infection;
  • C. jejuni oxidative and aerobic stress responses;
  • Mechanisms of C. jejuni invasion of intestinal epithelial cells;
  • Role of the C. jejuni Type VI Secretion System;
  • The innate immune response to C. jejuni infection.

A long term interest has been developing new technology associated with functional genomic research. Nick was involved in the construction of the first DNA microarray produced by the Bacterial Microarray Group at St George's (http://bugs.sghms.ac.uk/index.php) and acted as User Group Co-ordinator for both the C. jejuni and H. pylori microarrays produced by the BμG@S group.

Nick has had a long involvement with the Microbiology Society (previously known as the Society of General Microbiology) (https://www.microbiologysociety.org). Nick stood down as Chair of the Prokaryotic Division in September 2013 after the 2 year term of office. Previously Nick was Chair Elect of the Prokaryotic Division (2009-2011), a member of the Prokaryotic Division (2008-2009) and Convener of the Microbial Infection Group (2005-2008), having served as a committee member of the Microbial Infection Group since 2001. He was also a member (2001-2007) of the Steering Committee of ARK Genomics (http://www.ark-genomics.org) based at the Roslin Institute (Edinburgh).

Research Area
Bacteria
Innate immunity
Disease control
Discipline
Genomics
Bacteriology
Cell biology
Genetics
Microbiology
Molecular biology
Disease and Health Conditions
Diarrhoeal diseases
Infectious disease
Zoonotic disease
Country
United Kingdom
Ireland
Region
Euro area

Selected Publications

The Campylobacter jejuni MarR-like transcriptional regulators RrpA and RrpB both influence bacterial responses to oxidative and aerobic stresses.
Gundogdu, O. ; da Silva, D.T. ; Mohammad, B. ; Elmi, A. ; Mills, D.C. ; Wren, B.W. ; Dorrell, N. ;
Front Microbiol
Campylobacter jejuni lipooligosaccharide sialylation, phosphorylation and amide/ester linkage modifications fine-tune human Toll-like receptor 4 activation.
Stephenson, H.N.; John, C.M.; Naz, N.; Gundogdu, O.; Dorrell, N.; Wren, B.W.; Jarvis, G.A.; Bajaj-Elliott, M.;
J Biol Chem
Increase in Campylobacter jejuni invasion of intestinal epithelial cells under low oxygen co-culture conditions that reflect the in vivo environment.
Mills, D.C.; Gundogdu, O.; Elmi, A.; Bajaj-Elliott, M.; Taylor, P.W.; Wren, B.W.; Dorrell, N.;
Infect Immun
Campylobacter jejuni outer membrane vesicles play an important role in bacterial interactions with human intestinal epithelial cells.
Elmi, A.; Watson, E.; Sandu, P.; Gundogdu, O.; Mills, D.C.; Inglis, N.F.; Manson, E.; Imrie, L.; Bajaj-Elliott, M.; Wren, B.W.; Smith, D.G.; Dorrell, N.;
Infect Immun
Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes.
Hepworth, P.J.; Ashelford, K.E.; Hinds, J.; Gould, K.A.; Witney, A.A.; Williams, N.J.; Leatherbarrow, H.; French, N.P.; Birtles, R.J.; Mendonca, C.; Dorrell, N.; Wren, B.W.; Wigley, P.; Hall, N.; Winstanley, C.;
Environ Microbiol
Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence.
Gundogdu, O.; Bentley, S.D.; Holden, M.T.; Parkhill, J.; Dorrell, N.; Wren, B.W.;
BMC Genomics
See all Professor Nick Dorrell's Publications