Prof Nick Dorrell
Professor of Bacterial Pathogenesis
Nick Dorrell originally trained as a pharmacist, obtaining a Bachelor of Pharmacy degree from the University of Bath in 1988 and completing his pre-registration training at King's College Hospital in 1989. After two years working in hospital pharmacy, he returned to Bath to study DNA repair in Escherichia coli, completing his PhD in 1993. He joined Brendan Wren's research group at St Bartholomew's Hospital in January 1994, working on many different aspects of bacterial pathogenicity of Brucella species, Yersinia species and Helicobacter pylori. He joined the LSHTM in July 1999 and is continuing to study the pathogenicity of both H. pylori and predominantly Campylobacter jejuni.
From September 2016 to September 2022, Nick was the Taught Programme Director for the Faculty of Infectious & Tropical Diseases, with oversight of all teaching on the MSc Programmes (both Intensive and Distance Learning) and Short Courses run by the Faculty. Previously Nick was the Programme Director for the MSc in Medical Microbiology (https://www.lshtm.ac.uk/study/masters/medical-microbiology) from 2005 to 2016. During this time, he also acted as Module Organiser for the MSc Modules on Bacteriology, Clinical Bacteriology and Clinical Virology and also lectured on the MSc Module Advanced Training in Molecular Biology. He chaired the Course Committee and was a member of the Exam Board for the MSc in Medical Microbiology.
During the 2022-2023 academic year, Nick lectures on the MSc Modules on Bacteriology and Advanced Training in Molecular Biology.
Nick currently supervises two PhD students and also supervises MSc research projects at the LSHTM.
Nick successfully completed the Professional Certificate in Teaching and Learning in Higher and Professional Education (with Distinction) at the Institute of Education (University of London) in 2006 and became a Fellow of The Higher Education Academy in 2007.
Current research interests cover five main areas of bacterial pathogenesis:-
i) Role of outer membrane vesicles during C. jejuni infection;
ii) C. jejuni oxidative and aerobic stress responses;
iii) Mechanisms of C. jejuni invasion of intestinal epithelial cells;
iv) Role of the C. jejuni Type VI Secretion System;
v) The innate immune response to C. jejuni infection.
A long term interest has been developing new technology associated with functional genomic research. Nick was involved in the construction of the first DNA microarray produced by the Bacterial Microarray Group at St George's and acted as User Group Co-ordinator for both the C. jejuni and H. pylori microarrays produced by the BμG@S group.
Nick has had a long involvement with the Microbiology Society (previously known as the Society of General Microbiology) (https://www.microbiologysociety.org). Nick stood down as Chair of the Prokaryotic Division in September 2013 after the 2 year term of office. Previously Nick was Chair Elect of the Prokaryotic Division (2009-2011), a member of the Prokaryotic Division (2008-2009) and Convener of the Microbial Infection Group (2005-2008), having served as a committee member of the Microbial Infection Group since 2001. He was also a member (2001-2007) of the Steering Committee of ARK Genomics (http://www.ark-genomics.org) based at the Roslin Institute (Edinburgh).