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Professor Hazel Dockrell

BA PhD

Professor
of Immunology, Special Advisor on Overseas Partnerships in Africa

Room
286

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7927 2466

I initially did a BA degree in Microbiology at Trinity College Dublin, followed by a PhD in autoimmunity at the Royal Dental Hospital of London. After a period as a postdoc at the Middlesex Hospital Medical School working on malaria, I moved to the LSHTM in 1985. Initially I was working on the immunology of leprosy but this then led me into tuberculosis, BCG vaccination and biomarkers. I now also help as Special Advisor on our Overseas Programmes in Africa.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases
Executive Office

Centres

TB Centre
Vaccine Centre

Teaching

With members of my research group, I teach and tutor on the MSc Immunology of Infectious Diseases course.

Research

Our research aims to understand the basis of protective immunity against tuberculosis and in particular to identify biomarker signatures that would help in the development of new TB vaccines. We are also interested in how TB treatment modulates immune and gene expression signatures, and in how co-morbidity with helminth infections or diabetes impact on immunity to Mycobacterium tuberculosis.

Research Area
Helminths
T-cell immunology
Vaccines
Capacity strengthening
Global Health
Immunisation
Discipline
Immunoepidemiology
Immunology
Vaccinology
Disease and Health Conditions
Infectious disease
Leprosy
Tuberculosis
Chronic Fatigue Syndrome
Diabetes
Country
Ethiopia
United Kingdom
Indonesia
Republic of Korea
Pakistan
Romania
Uganda
South Africa
Region
East Asia & Pacific (all income levels)
European Union
Sub-Saharan Africa (all income levels)

Selected Publications

Identification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and Quantification.
Gliddon HD; Kaforou M; Alikian M; Habgood-Coote D; Zhou C; Oni T; Anderson ST; Brent AJ; Crampin AC; Eley B
2021
Frontiers in immunology
Immune Responses Following BCG Immunization of Infants in Uganda and United Kingdom Are Similar for Purified Protein Derivative but Differ for Secretory Proteins of Mycobacterium tuberculosis.
Mawa PA; Hasso-Agopsowicz M; Lubyayi L; Nabakooza G; Nakibuule M; Blitz R; Dun L; Govind A; Kaleebu P; Webb EL
2021
Frontiers in immunology
Evaluation of Host Serum Protein Biomarkers of Tuberculosis in sub-Saharan Africa.
Morris TC; Hoggart CJ; Chegou NN; Kidd M; Oni T; Goliath R; Wilkinson KA; Dockrell HM; Sichali L; Banda L
2021
Frontiers in immunology
Validation and Optimization of Host Immunological Bio-Signatures for a Point-of-Care Test for TB Disease.
Mutavhatsindi H; van der Spuy GD; Malherbe ST; Sutherland JS; Geluk A; Mayanja-Kizza H; Crampin AC; Kassa D; Howe R; Mihret A
2021
Frontiers in immunology
BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial.
Prentice S; Nassanga B; Webb EL; Akello F; Kiwudhu F; Akurut H; Elliott AM; Arts RJW; Netea MG; Dockrell HM
2021
The Lancet. Infectious diseases
Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa.
Alisjahbana B; McAllister SM; Ugarte-Gil C; Panduru NM; Ronacher K; Koesoemadinata RC; Zubiate C; Riza AL; Malherbe ST; Kleynhans L
2020
Transactions of the Royal Society of Tropical Medicine and Hygiene
Monitoring Anti-tuberculosis Treatment Response Using Analysis of Whole Blood Mycobacterium tuberculosis Specific T Cell Activation and Functional Markers.
Vickers MA; Darboe F; Muefong CN; Mbayo G; Barry A; Gindeh A; Njie S; Riley A-J; Sarr B; Sambou B
2020
FRONTIERS IN IMMUNOLOGY
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