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Professor Hazel Dockrell

BA PhD

Professor
of Immunology, Special Advisor on Overseas Partnerships in Africa

Room
286

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7927 2466
Jump to: Affiliations Teaching Research Publications

I initially did a BA degree in Microbiology at Trinity College Dublin, followed by a PhD in autoimmunity at the Royal Dental Hospital of London. After a period as a postdoc at the Middlesex Hospital Medical School working on malaria, I moved to the LSHTM in 1985. Initially I was working on the immunology of leprosy but this then led me into tuberculosis, BCG vaccination and biomarkers. I now also help as Special Advisor on our Overseas Programmes in Africa.

Affiliations

Executive Office
Faculty of Infectious and Tropical Diseases
Department of Immunology and Infection

Centres

Tuberculosis (TB) Centre
Vaccine Centre

Teaching

With members of my research group, I teach and tutor on the MSc Immunology of Infectious Diseases course.

Research

Our research aims to understand the basis of protective immunity against tuberculosis and in particular to identify biomarker signatures that would help in the development of new TB vaccines. We are also interested in how TB treatment modulates immune and gene expression signatures, and in how co-morbidity with helminth infections or diabetes impact on immunity to Mycobacterium tuberculosis.

Research Area
Helminths
T-cell immunology
Vaccines
Capacity strengthening
Global Health
Immunisation
Discipline
Immunoepidemiology
Immunology
Vaccinology
Disease and Health Conditions
Infectious disease
Leprosy
Tuberculosis
Chronic Fatigue Syndrome
Diabetes
Country
Ethiopia
United Kingdom
Indonesia
Korea, Rep.
Pakistan
Romania
Uganda
South Africa
Region
East Asia & Pacific (all income levels)
European Union
Sub-Saharan Africa (all income levels)

Selected Publications

Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment.
Cliff, J.M.; Cho, J.E.; Lee, J.S.; Ronacher, K.; King, E.C.; van Helden, P.; Walzl, G.; Dockrell, H.M.;
2016
J Infect Dis
Mycobacterium tuberculosis-specific CD4(+) T-cell response is increased, and Treg cells decreased, in anthelmintic-treated patients with latent TB.
Toulza, F. ; Tsang, L. ; Ottenhoff, T.H. ; Brown, M. ; Dockrell, H.M. ;
2016
Eur J Immunol
A blood RNA signature for tuberculosis disease risk: a prospective cohort study.
Zak, D.E. ; Penn-Nicholson, A. ; Scriba, T.J. ; Thompson, E. ; Suliman, S. ; Amon, L.M. ; Mahomed, H. ; Erasmus, M. ; Whatney, W. ; Hussey, G.D. ; Abrahams, D. ; Kafaar, F. ; Hawkridge, T. ; Verver, S. ; Hughes, E.J. ; Ota, M. ; Sutherland, J. ; Howe, R. ; Dockrell, H.M. ; Boom, W.H. ; Thiel, B. ; Ottenhoff, T.H. ; Mayanja-Kizza, H. ; Crampin, A.C. ; Downing, K. ; Hatherill, M. ; Valvo, J. ; Shankar, S. ; Parida, S.K. ; Kaufmann, S.H. ; Walzl, G. ; Aderem, A. ; Hanekom, W.A. ; ACS and GC6-74 cohort study groups, . ; COLLABORATORS;Kafaar, F. ; Workman, L. ; Mulenga, H. ; Scriba, T. ; Ehrlich, R. ; Abrahams, D. ; Moyo, S. ; Gelderbloem, S. ; Tameris, M. ; Geldenhuys, H. ; Hanekom, W. ; Hussey, G. ; Ehrlich, R. ; Verver, S. ; Geiter, L. ; Kaufmann, S.H. ; Parida, S.K. ; Golinski, R. ; Maertzdorf, J. ; Weiner, J. ; Jacobson, M. ; Walzl, G. ; Black, G. ; van der Spuy, G. ; Stanley, K. ; Kriel, D. ; Du Plessis, N. ; Nene, N. ; Loxton, A. ; Chegou, N. ; Suliman, S. ; Scriba, T. ; Mahomed, H. ; Hughes, J. ; Downing, K. ; Penn-Nicholson, A. ; Mulenga, H. ; Abel, B. ; Bowmaker, M. ; Kagina, B. ; Kwong C, W. ; Hanekom, W. ; Ottenhoff, T.H. ; Klein, M.R. ; Haks, M.C. ; Franken, K.L. ; Geluk, A. ; van Meijgaarden, K.E. ; Joosten, S.A. ; van Baarle, D. ; Miedema, F. ; Boom, W.H. ; Thiel, B. ; Sadoff, J. ; Sizemore, D. ; Ramachandran, S. ; Barker, L. ; Brennan, M. ; Weichold, F. ; Muller, S. ; Geiter, L. ; Schoolnik, G. ; Dolganov, G. ; Van, T. ; Mayanja-Kizza, H. ; Joloba, M. ; Zalwango, S. ; Nsereko, M. ; Okwera, B. ; Kisingo, H. ; Dockrell, H. ; Smith, S. ; Gorak-Stolinska, P. ; Hur, Y.G. ; Lalor, M. ; Lee, J.S. ; Crampin, A.C. ; French, N. ; Ngwira, B. ; Smith, A.B. ; Watkins, K. ; Ambrose, L. ; Simukonda, F. ; Mvula, H. ; Chilongo, F. ; Saul, J. ; Branson, K. ; Kassa, D. ; Abebe, A. ; Mesele, T. ; Tegbaru, B. ; Howe, R. ; Mihret, A. ; Aseffa, A. ; Bekele, Y. ; Iwnetu, R. ; Tafesse, M. ; Yamuah, L. ; Ota, M. ; Sutherland, J. ; Hill, P. ; Adegbola, R. ; Corrah, T. ; Antonio, M. ; Togun, T. ; Adetifa, I. ; Donkor, S. ; Andersen, P. ; Rosenkrands, I. ; Doherty, M. ; Weldingh, K. ;
2016
Lancet
Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants.
Smith, S.G. ; Zelmer, A. ; Blitz, R. ; Fletcher, H.A. ; Dockrell, H.M. ;
2016
Vaccine
Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines.
Smith, S.G. ; Smits, K. ; Joosten, S.A. ; van Meijgaarden, K.E. ; Satti, I. ; Fletcher, H.A. ; Caccamo, N. ; Dieli, F. ; Mascart, F. ; McShane, H. ; Dockrell, H.M. ; Ottenhoff, T.H. ; TBVI TB Biomarker Working Group, . ;
2015
PLoS One
TANDEM: understanding diabetes and tuberculosis.
van Crevel, R. ; Dockrell, H.M. ; TANDEM Consortium, . ;
2014
Lancet Diabetes Endocrinol
BCG Vaccination Induces Different Cytokine Profiles Following Infant BCG Vaccination in the UK and Malawi.
Lalor, M.K. ; Floyd, S. ; Gorak-Stolinska, P. ; Ben-Smith, A. ; Weir, R.E. ; Smith, S.G. ; Newport, M.J. ; Blitz, R. ; Mvula, H. ; Branson, K. ; McGrath, N. ; Crampin, A.C. ; Fine, P.E. ; Dockrell, H.M. ;
2011
J Infect Dis
BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies
Black, G. F.; Weir, R. E.; Floyd, S.; Bliss, L.; Warndorff, D. K.; Crampin, A. C.; Ngwira, B.; Sichali, L.; Nazareth, B.; Blackwell, J. M.; Branson, K.; Chaguluka, S. D.; Donovan, L.; Jarman, E.; King, E.; Fine, P. E. M.; Dockrell, H. M.
2002
Lancet
See all Professor Hazel Dockrell's Publications

Contact

Room
286

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7927 2466