Prof Keertan Dheda

Professor of TB Research

United Kingdom

Keertan Dheda holds a joint appointment between the LSHTM (Professor of Mycobacteriology and Global Health) and the University of Cape Town (UCT), where is the Director of the Centre for Lung Infection and Immunity. After graduating at the University of Witwatersrand in 1992 (Certificate of Merit) he completed UK and EU-accredited training in Respiratory and General Internal Medicine in London. He graduated with a PhD from UCL in 2005 through a British Lung Foundation Fellowship award.


Department of Infection Biology
Faculty of Infectious and Tropical Diseases


Keertan mentors Masters, PhD, and post doctoral trainees, and teaches on specific courses at the LSHTM. From a global health perspective, he has established an international collaborative network and a research programme in which several Masters and PhD students are currently enrolled. He is currently or has previously been involved in several capacity building-related global health programmes including those with UCL, New York University (NYU), South Western Medical School (Dallas), AIIMS (New Delhi, India), SVIMS (Tirupati, India), McGill (Canada), and several African (Zimbabwe, Zambia, Tanzania, Mozambique, Botswana and Malawi) and European countries (UK, Germany, Italy, Netherlands).

Selected teaching and training activities:

i) A masters student in Infectious Diseases (Taeuk Kang) completed his research project and submitted his dissertation recently.

ii) Three LSHTM postdoctoral scientists are being trained through ongoing collaborative projects.

iii) Keertan lectured on the MSc in TB Immunology course (2 lectures).

iv) He is an advisor on the LSHTM Genomics course run by Professor Taane Clark.

v) A scientist from UCT (Dr Pooran; funded by an EU grant) will undergo training in sequencing and bio-informatics at the LSHTM.

vi) Two UCT scientists (Drs Pooran and Londt) are part of the Wellcome Human Challenge Model working group (the major UK MRC grant is held at

the LSHTM).


His main research interests include the diagnosis, determinants, and outcomes of drug sensitive and drug resistant TB. He holds 6 patents related to new TB diagnostic, therapeutic or infection control technologies, one of which is currently being developed as a user-friendly test for extra-pulmonary tuberculosis. He serves in an editorial advisory capacity of several journals including Lancet Respiratory Medicine (highest ranked in Respiratory Medicine; IF= 76.2), American Journal of Respiratory and Critical Medicine (second highest ranked in Respiratory Medicine; IF= ~30), and the British Medical Journal (ranked 4th amongst general medical journals; IF= ~100), amongst others. He has been the recipient of several prestigious international awards including the International Union Against Tuberculosis and Lung Disease Scientific Award and the European Union-funded EDCTP Scientific Leadership Award. He is the founder and co-director of the charity, Free of TB, which seeks to promote the well-being of patients with TB.

Research Area
Respiratory system
Clinical trials
Disease and Health Conditions
Respiratory diseases
United Kingdom
South Africa
Sub-Saharan Africa (all income levels)

Selected Publications

Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis.
Theron, G; Limberis, J; Venter, R; Smith, L; Pietersen, E; Esmail, A; Calligaro, G; Te Riele, J; De Kock, M; Van Helden, P; Gumbo, T; CLARK, TG; Fennelly, K; Warren, R; DHEDA, K;
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.
COLL, F; PHELAN, J; Hill-Cawthorne, GA; Nair, MB; Mallard, K; Ali, S; Abdallah, AM; Alghamdi, S; Alsomali, M; Ahmed, AO; Portelli, S; OPPONG, Y; Alves, A; Bessa, TB; CAMPINO, S; Caws, M; Chatterjee, A; CRAMPIN, AC; DHEDA, K; FURNHAM, N; GLYNN, JR; Grandjean, L; Minh Ha, D; Hasan, R; Hasan, Z; ... CLARK, TG.
Nature genetics
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis.
Miotto, P; Tessema, B; Tagliani, E; Chindelevitch, L; Starks, AM; Emerson, C; Hanna, D; Kim, PS; Liwski, R; Zignol, M; Gilpin, C; Niemann, S; Denkinger, CM; Fleming, J; Warren, RM; Crook, D; Posey, J; Gagneux, S; Hoffner, S; Rodrigues, C; Comas, I; Engelthaler, DM; Murray, M; Alland, D; Rigouts, L; ... Rodwell, TC.
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis.
DHEDA, K; Gumbo, T; Maartens, G; Dooley, KE; McNerney, R; Murray, M; Furin, J; Nardell, EA; London, L; Lessem, E; Theron, G; Van Helden, P; Niemann, S; Merker, M; Dowdy, D; Van Rie, A; Siu, GK H; Pasipanodya, JG; Rodrigues, C; CLARK, TG; Sirgel, FA; Esmail, A; Lin, H-H; Atre, SR; Schaaf, HS; ... Warren, RM.
The lancet Respiratory medicine
Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study.
DHEDA, K; Limberis, JD; Pietersen, E; PHELAN, J; Esmail, A; Lesosky, M; Fennelly, KP; Te Riele, J; Mastrapa, B; Streicher, EM; Dolby, T; Abdallah, AM; Ben-Rached, F; Simpson, J; Smith, L; Gumbo, T; Van Helden, P; Sirgel, FA; McNerney, R; Theron, G; Pain, A; CLARK, TG; Warren, RM;
The lancet Respiratory medicine
DHEDA, K; Barry, CE; Maartens, G;
Lancet (London, England)
Determinants of PCR performance (Xpert MTB/RIF), including bacterial load and inhibition, for TB diagnosis using specimens from different body compartments.
Theron, G; Peter, J; Calligaro, G; Meldau, R; Hanrahan, C; Khalfey, H; Matinyenya, B; Muchinga, T; Smith, L; Pandie, S; Lenders, L; Patel, V; Mayosi, BM; DHEDA, K;
Scientific reports
Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial.
Theron, G; Zijenah, L; Chanda, D; Clowes, P; Rachow, A; Lesosky, M; Bara, W; Mungofa, S; Pai, M; Hoelscher, M; Dowdy, D; Pym, A; Mwaba, P; Mason, P; Peter, J; DHEDA, K; TB-NEAT team,;
Lancet (London, England)
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: a prospective study.
Patel, VB; Theron, G; Lenders, L; Matinyena, B; Connolly, C; Singh, R; Coovadia, Y; Ndung'u, T; DHEDA, K;
PLoS medicine
What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa?
Pooran, A; Pieterson, E; Davids, M; Theron, G; DHEDA, K;
PloS one
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