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Professor Keertan Dheda

MBBCh FCP(SA) FCCP PhD (Lond) FRCP (Lond)

Professor
of Mycobacteriology and Global Health

Room
K284

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7927 2484

 

Keertan Dheda holds a joint appointment between the LSHTM (Professor of Mycobacteriology and Global Health) and the University of Cape Town (UCT), where is the Director of the Centre for Lung Infection and Immunity (see: https://lunginstitute.co.za/liiu/ ).  After graduating at the University of Witwatersrand in 1992 (Certificate of Merit) he then completed UK and EU-accredited training in Respiratory Medicine in London. He graduated with a PhD from UCL in 2005 through a British Lung Foundation Fellowship award.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

TB Centre
Vaccine Centre
Antimicrobial Resistance Centre (AMR)

Teaching

Keertan mentors Masters, PhD, and post doctoral trainees, and teaches on specific courses and seminars but does not do regular face-to-face teaching at the LSHTM. From a global health perspective, he has established an international collaborative network and a research programme in which several Masters and PhD students are currently enrolled. He is currently or has previously been involved in several capacity building-related global health programmes including those with UCL, New York University (NYU), South Western Medical School (Dallas), AIIMS (New Delhi, India), SVIMS (Tirupati, India), McGill (Canada), and several African (Zimbabwe, Zambia, Tanzania, Mozambique, Botswana and Malawi) and European countries (UK, Germany, Italy, Netherlands). 

Research

His main research interests include the diagnosis, determinants, and outcomes of drug sensitive and drug resistant TB. He hold 5 patents related to new TB diagnostic, therapeutic or infection control technologies, one of which is currently being developed as a user-friendly test for extra-pulmonary tuberculosis. He serves on the editorial board of several journals including Lancet Respiratory Diseases (highest ranked in Respiratory Medicine; IF= 21.5), American Journal of Respiratory and Critical Medicine (second highest ranked in Respiratory Medicine; IF= ~16.5), Scientific Reports (Nature Group of journals), PLoS One, and the International Journal of Tuberculosis and Lung Disease, amongst others. He has been the recipient of several prestigious international awards including the 2010 International Union Against Tuberculosis and Lung Disease Scientific Award and the 2018 European Union-funded EDCTP Scientific Leadership Award. He is the founder and co-director of the charity, Free of TB, which seeks to promote the well-being of patients with TB.

Research Area
Clinical trials
Diagnostics
Innate immunity
Social and structural determinants of health
Vaccines
Randomised controlled trials
Discipline
Genomics
Molecular epidemiology
Bacteriology
Epidemiology
Immunology
Medicine
Microbiology
Bioinformatics
Vaccinology
Disease and Health Conditions
HIV/AIDS
Infectious disease
Tuberculosis
Respiratory disease
Country
Mozambique
South Africa
Zambia
Zimbabwe
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.
Coll F; Phelan J; Hill-Cawthorne GA; Nair MB; Mallard K; Ali S; Abdallah AM; Alghamdi S; Alsomali M; Ahmed AO
2018
Nature genetics
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis.
Dheda K; Gumbo T; Maartens G; Dooley KE; McNerney R; Murray M; Furin J; Nardell EA; London L; Lessem E
2017
The lancet Respiratory medicine
Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study.
Dheda K; Limberis JD; Pietersen E; Phelan J; Esmail A; Lesosky M; Fennelly KP; Te Riele J; Mastrapa B; Streicher EM
2017
The lancet Respiratory medicine
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis.
Miotto P; Tessema B; Tagliani E; Chindelevitch L; Starks AM; Emerson C; Hanna D; Kim PS; Liwski R; Zignol M
2017
EUROPEAN RESPIRATORY JOURNAL
Tuberculosis.
Dheda K; Barry CE; Maartens G
2016
Lancet (London, England)
Determinants of PCR performance (Xpert MTB/RIF), including bacterial load and inhibition, for TB diagnosis using specimens from different body compartments.
Theron G; Peter J; Calligaro G; Meldau R; Hanrahan C; Khalfey H; Matinyenya B; Muchinga T; Smith L; Pandie S
2014
Scientific reports
Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial.
Theron G; Zijenah L; Chanda D; Clowes P; Rachow A; Lesosky M; Bara W; Mungofa S; Pai M; Hoelscher M
2014
Lancet (London, England)
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: a prospective study.
Patel VB; Theron G; Lenders L; Matinyena B; Connolly C; Singh R; Coovadia Y; Ndung'u T; Dheda K
2013
PLoS medicine
What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa?
Pooran A; Pieterson E; Davids M; Theron G; Dheda K
2013
PloS one
Diagnostic accuracy of a urine lipoarabinomannan strip-test for TB detection in HIV-infected hospitalised patients.
Peter JG; Theron G; van Zyl-Smit R; Haripersad A; Mottay L; Kraus S; Binder A; Meldau R; Hardy A; Dheda K
2012
The European respiratory journal
Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting.
Theron G; Peter J; van Zyl-Smit R; Mishra H; Streicher E; Murray S; Dawson R; Whitelaw A; Hoelscher M; Sharma S
2011
American journal of respiratory and critical care medicine
Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples.
Dheda K; Davids V; Lenders L; Roberts T; Meldau R; Ling D; Brunet L; van Zyl Smit R; Peter J; Green C
2010
PloS one
Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus- and tuberculosis-endemic population.
Patel VB; Singh R; Connolly C; Coovadia Y; Peer AKC; Parag P; Kasprowicz V; Zumla A; Ndung'u T; Dheda K
2010
American journal of respiratory and critical care medicine
Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis.
Pooran A; Booth H; Miller RF; Scott G; Badri M; Huggett JF; Rook G; Zumla A; Dheda K
2010
BMC pulmonary medicine
Utility of quantitative T-cell responses versus unstimulated interferon-{gamma} for the diagnosis of pleural tuberculosis.
Dheda K; van Zyl-Smit RN; Sechi LA; Badri M; Meldau R; Meldau S; Symons G; Semple PL; Maredza A; Dawson R
2009
The European respiratory journal
Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting.
Dheda K; Van-Zyl Smit RN; Sechi LA; Badri M; Meldau R; Symons G; Khalfey H; Carr I; Maredza A; Dawson R
2009
PloS one
Within-subject variability and boosting of T-cell interferon-gamma responses after tuberculin skin testing.
van Zyl-Smit RN; Pai M; Peprah K; Meldau R; Kieck J; Juritz J; Badri M; Zumla A; Sechi LA; Bateman ED
2009
American journal of respiratory and critical care medicine
In vivo and in vitro studies of a novel cytokine, interleukin 4delta2, in pulmonary tuberculosis.
Dheda K; Chang J-S; Breen RAM; Kim LU; Haddock JA; Huggett JF; Johnson MA; Rook GAW; Zumla A
2005
American journal of respiratory and critical care medicine
The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalization.
Dheda K; Huggett JF; Chang JS; Kim LU; Bustin SA; Johnson MA; Rook GA; Zumla A
2005
Analytical biochemistry
Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count.
Dheda K; Lalvani A; Miller RF; Scott G; Booth H; Johnson MA; Zumla A; Rook GA
2005
AIDS (London, England)
Validation of housekeeping genes for normalizing RNA expression in real-time PCR.
Dheda K; Huggett JF; Bustin SA; Johnson MA; Rook G; Zumla A
2004
BioTechniques
Experience with azathioprine in systemic sclerosis associated with interstitial lung disease.
Dheda K; Lalloo UG; Cassim B; Mody GM
2004
Clinical rheumatology
Outcome of HIV-associated tuberculosis in the era of highly active antiretroviral therapy.
Dheda K; Lampe FC; Johnson MA; Lipman MC
2004
The Journal of infectious diseases
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