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Prof Umberto D'Alessandro

MRC - Unit Director

Medical Research Council The Gambia Unit
Atlantic Boulevard
Fajara
Gambia

Prof. Umberto D'Alessandro graduated in Medicine & Surgery at the University of Pisa, Italy, and then obtained both his MSc and PhD at the London School of Hygiene and Tropical Medicine, UK, in 1990 and 1996 respectively. He worked as a clinician in Benin and Kenya. In 1990, he joined the MRC Unit The Gambia as clinical epidemiologist and carried out the evaluation of the Gambian National Program on insecticide-treated bed nets that showed the intervention decreased mortality among children by 25%. In 1996, he joined the Institute of Tropical Medicine, Antwerp, Belgium, where he developed a research program around three themes: antimalarial treatment, including drug resistance, malaria prevention, and the P. vivax in vitro cycle, implemented in several malaria endemic countries, e.g. Uganda, Burkina Faso, Benin, Vietnam, Peru, etc. In 2011, he joined the Medical Research Council Unit The Gambia (MRCG) as the leader of the Disease Control & Elimination Theme. In January 2014, he was appointed Director of the Unit and Professor of Epidemiology at the London School of Hygiene and Tropical Medicine. His research program on malaria is built around questions related to malaria elimination/eradication.

Affiliations

MRC Unit The Gambia at LSHTM

Centres

Vaccine Centre
Centre on Climate Change and Planetary Health

Teaching

I taught for several years in the MSc Disease Control at the Institute of Tropical Medicine, Antwerp, Belgium. I was also member of the management team of this MSc course. I was also course organizer for several years of the International course on Planning and Management of Tropical Diseases Control Programmes (10 weeks) at the Institute of Tropical Medicine, Antwerp, Belgium. I have also taught in other courses in Italy and The Netherlands. I have supervised 24 PhD students who completed their degree. I am currently supervising 5 PhD students. I was also the supervisor of 34 MSc students. I am currently teaching in the introductory course of epidemiology and medical statistics at the London School of Hygiene and Tropical Medicine.

Research

My main research interest has been and continue to be on malaria, although I have been involved in research on hepatitis B, bacterial diseases, and more recently COVID-19. For malaria, I have investigated malaria transmission in Africa, Southeast Asia and Latin America, and evaluated preventive interventions such as insecticide-treated bed nets, indoor residual spraying, mass drug administration, and malaria vaccines. I have also evaluated new antimalarial treatments and drug resistance, and new tools for the diagnosis of malaria, both for patients with suspected clinical malaria and for asymptomatic carriers.

Selected Publications

Plasmodium falciparum population structure and genetic diversity of cell traversal protein for ookinetes and sporozoites (CelTOS) during malaria resurgences in Dielmo, Senegal.
Wotodjo, AN; Oboh, MA; Sokhna, C; Diagne, N; Diène-Sarr, F; Trape, J-F; Doucouré, S; AMAMBUA-NGWA, A; D'ALESSANDRO, U;
2023
Infection, genetics and evolution
The Precise-DYAD Neurodevelopmental substudy protocol: neurodevelopmental risk in children of mothers with placental complications
Magai, DN; Chandna, J; Volvert, M-L; Craik, R; Jah, H; Kongira, F; Bojang, K; Koech, A; Mwashigadi, G; Mutua, AM; BLENCOWE, H; D'ALESSANDRO, U; Roca, A; Temmerman, M; Von Dadelszen, P; Abubakar, A; Gladstone, M;
2023
Wellcome Open Research
A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study.
Jackson, HR; Zandstra, J; Menikou, S; Hamilton, MS; McArdle, AJ; Fischer, R; Thorne, AM; Huang, H; Tanck, MW; Jansen, MH; De, T; Agyeman, PK A; Von Both, U; Carrol, ED; Emonts, M; Eleftheriou, I; Van der Flier, M; Fink, C; Gloerich, J; De Groot, R; Moll, HA; Pokorn, M; Pollard, AJ; Schlapbach, LJ; Tsolia, MN; ... PERFORM consortium,
2023
The Lancet. Digital health
Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of <i>P. falciparum</i> uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial.
Djimde, M; Tshiongo, JK; Muhindo, HM; Tinto, H; Sevene, E; Traore, M; Vala, A; Macuacua, S; Kabore, B; Dabira, ED; Erhart, A; Diakite, H; Keita, M; Piqueras, M; González, R; Menendez, C; Dorlo, TP; Sagara, I; Mens, P; Schallig, H; D'ALESSANDRO, U; Kayentao, K;
2023
BMJ open
Rebound of multiple infections and prevalence of anti-malarial resistance associated markers following malaria upsurges in Dielmo village, Senegal, West Africa
Wotodjo, AN; Oboh, MA; Doucoure, S; Diagne, N; Diène-Sarr, F; Niang, M; Trape, J-F; Sokhna, C; AMAMBUA-NGWA, A; D'ALESSANDRO, U;
2023
Malaria journal
Recent increase in low complexity polygenomic infections and sialic acid-independent invasion pathways in Plasmodium falciparum from Western Gambia.
Nganyewo, NN; Bojang, F; ORIERO, EC; Drammeh, NF; Ajibola, O; Mbye, H; Jawara, AS; Corea, S; Awandare, GA; D'ALESSANDRO, U; Amenga-Etego, LN; AMAMBUA-NGWA, A;
2023
Parasites & vectors
Association of diabetes, smoking, and alcohol use with subclinical-to-symptomatic spectrum of tuberculosis in 16 countries: an individual participant data meta-analysis of national tuberculosis prevalence surveys.
Hamada, Y; Quartagno, M; Law, I; Malik, F; Bonsu, FA; ADETIFA, IM O; Adusi-Poku, Y; D'ALESSANDRO, U; BASHORUN, AO; Begum, V; Lolong, DB; Boldoo, T; Dlamini, T; Donkor, S; Dwihardiani, B; Egwaga, S; Farid, MN; Celina G Garfin, AM; Mae G Gaviola, D; Husain, MM; Ismail, F; Kaggwa, M; Kamara, DV; Kasozi, S; Kaswaswa, K; ... Rangaka, MX.
2023
EClinicalMedicine
SARS-CoV-2 seroprevalence in pregnant women during the first three COVID-19 waves in The Gambia.
JANHA, RE; Bah, A; Jah, H; TOURAY, F; IDRIS, Y; Keita, S; Gaye, Y; Jallow, S; Faye-Joof, T; Njie, B; Craik, R; MOHAMMED, NI; Von Dadelszen, P; D'ALESSANDRO, U; ROCA, A; PRECISE Network,;
2023
International journal of infectious diseases
Clinical characteristics and outcomes of patients with cirrhosis and hepatocellular carcinoma in The Gambia, west Africa: a prospective cohort study.
NDOW, G; Vo-Quang, E; Shimakawa, Y; Ceesay, A; Tamba, S; Njai, HF; Bojang, L; Hateley, C; Takao, Y; Opoku, E; Warsop, Z; Ingiliz, P; D'ALESSANDRO, U; Chemin, I; Mendy, M; Thursz, M; Njie, R; Lemoine, M;
2023
The Lancet. Global health
Protocol for a cluster randomised placebo-controlled trial of adjunctive ivermectin mass drug administration for malaria control on the Bijagós Archipelago of Guinea-Bissau: the MATAMAL trial.
HUTCHINS, H; BRADLEY, J; PRETORIUS, E; Teixeira da Silva, E; VASILEVA, H; JONES, RT; Ndiath, MO; Dit Massire Soumare, H; MABEY, D; Nante, EJ; Martins, C; Logan, JG; Slater, H; DRAKELEY, C; D'ALESSANDRO, U; Rodrigues, A; LAST, AR;
2023
BMJ open
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