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Prof Taane Clark

Professor of Genomics and Global Health

United Kingdom

Taane has expertise in biostatistics, statistical and population genetics, and genomic epidemiology.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre
Centre for Mathematical Modelling of Infectious Diseases
TB Centre
Antimicrobial Resistance Centre

Research

His main research interests include the design and analysis of large-scale association studies of infectious diseases in humans, and the investigation of genetic variation in pathogen populations using high-throughput sequencing and genotyping technologies. He is leading global genetic diversity projects of Mycobacterium tuberculosis and Plasmodium species, as well as developing statistical and informatic tools to integrate genetic and important phenotypic information and identify genetic regions associated with important disease phenotypes (e.g. drug resistance). He organises short courses in Infectious Disease 'omics and Genomic epidemiology.

Research Area
Bacteria
Drug resistance
Global Health
Human genetics
Outbreaks
Parasites
Vector control
Bioinformatics
Genetic Epidemiology
Genomics
Disease and Health Conditions
Diarrhoeal diseases
Malaria
Tuberculosis
Infectious diseases
Vector borne diseases
Region
World

Selected Publications

Rapid profiling of Plasmodium parasites from genome sequences to assist malaria control.
PHELAN, JE; Turkiewicz, A; Manko, E; THORPE, J; VANHEER, LN; Van de Vegte-Bolmer, M; Ngoc, NT H; Binh, NT H; Thieu, NQ; Gitaka, J; Nolder, D; BESHIR, KB; Dombrowski, JG; Di Santi, SM; Bousema, T; SUTHERLAND, CJ; CAMPINO, S; CLARK, TG;
2023
Genome medicine
Detection of insecticide resistance markers in Anopheles funestus from the Democratic Republic of the Congo using a targeted amplicon sequencing panel.
Acford-Palmer, H; Campos, M; Bandibabone, J; N'Do, S; Bantuzeko, C; Zawadi, B; Walker, T; PHELAN, JE; Messenger, LA; CLARK, TG; CAMPINO, S;
2023
Scientific reports
Mixed infections in genotypic drug-resistant Mycobacterium tuberculosis.
Wang, L; CAMPINO, S; PHELAN, J; CLARK, TG;
2023
Scientific reports
Functional genetic variation in <i>pe</i>/<i>ppe</i> genes contributes to diversity in <i>Mycobacterium tuberculosis</i> lineages and potential interactions with the human host.
Gómez-González, PJ; Grabowska, AD; TIENTCHEU, LD; Tsolaki, AG; HIBBERD, ML; CAMPINO, S; PHELAN, JE; CLARK, TG;
2023
Frontiers in microbiology
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H<sub>2</sub>S)-producing variants of <i>Escherichia coli</i>.
Mazumder, R; Hussain, A; Rahman, MM; PHELAN, JE; CAMPINO, S; Abdullah, A; CLARK, TG; Mondal, D;
2023
Frontiers in microbiology
High throughput human genotyping for variants associated with malarial disease outcomes using custom targeted amplicon sequencing.
Osborne, A; PHELAN, JE; VANHEER, LN; Manjurano, A; Gitaka, J; DRAKELEY, CJ; Kaneko, A; Kita, K; CAMPINO, S; CLARK, TG;
2023
Scientific reports
Drug resistance profiling of asymptomatic and low-density Plasmodium falciparum malaria infections on Ngodhe island, Kenya, using custom dual-indexing next-generation sequencing.
OSBORNE, A; PHELAN, JE; Kaneko, A; Kagaya, W; Chan, C; Ngara, M; Kongere, J; Kita, K; Gitaka, J; CAMPINO, S; CLARK, TG;
2023
Scientific reports
Comparison of in silico predicted Mycobacterium tuberculosis spoligotypes and lineages from whole genome sequencing data.
Napier, G; Couvin, D; Refrégier, G; Guyeux, C; Meehan, CJ; Sola, C; CAMPINO, S; PHELAN, J; CLARK, TG;
2023
Scientific reports
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