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Professor Taane Clark

DPhil

Professor
of Genomics and Global Health

Room
K284

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7927 2484

Taane has expertise in biostatistics, statistical and population genetics, and genomic epidemiology

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Pathogen Molecular Biology
Faculty of Epidemiology and Population Health
Department of Infectious Disease Epidemiology

Centres

Malaria Centre
Mathematical Modelling of Infectious Diseases
Statistical Methodology
Tuberculosis (TB) Centre

Teaching

Pathogen genomics, Genetic epidemiology

Research

His main research interests include the design and analysis of large-scale association studies of infectious diseases in humans, and the investigation of genetic variation in pathogen populations using high-throughput sequencing and genotyping technologies. He is leading global genetic diversity projects of Mycobacterium tuberculosis and Plasmodium species, as well as developing statistical and informatic tools to integrate genetic and important phenotypic information and identify genetic regions associated with important disease phenotypes (e.g. drug resistance). He organises short courses in Pathogen genomics and Genetic epidemiology. Further details can be found at pathogenseq.lshtm.ac.uk

Research Area
Bacteria
Drug resistance
Human genetics
Parasites
Public health history
Statistical methods
Global Health
Discipline
Genetic epidemiology
Genomics
Molecular epidemiology
Epidemiology
Genetics
Statistics
Bioinformatics
Disease and Health Conditions
Infectious disease
Malaria
Tuberculosis
Non-communicable diseases
Region
World

Selected Publications

Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study.
Dheda, K. ; Limberis, J.D. ; Pietersen, E. ; Phelan, J. ; Esmail, A. ; Lesosky, M. ; Fennelly, K.P. ; Te Riele, J. ; Mastrapa, B. ; Streicher, E.M. ; Dolby, T. ; Abdallah, A.M. ; Ben-Rached, F. ; Simpson, J. ; Smith, L. ; Gumbo, T. ; van Helden, P. ; Sirgel, F.A. ; McNerney, R. ; Theron, G. ; Pain, A. ; Clark, T.G. ; Warren, R.M. ;
Lancet Respir Med
African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania.
Manjurano, A. ; Sepulveda, N. ; Nadjm, B. ; Mtove, G. ; Wangai, H. ; Maxwell, C. ; Olomi, R. ; Reyburn, H. ; Riley, E.M. ; Drakeley, C.J. ; Clark, T.G. ; MalariaGEN Consortium, . ;
PLoS Genet
USP38, FREM3, SDC1, DDC and LOC727982 gene polymorphisms and differential susceptibility to severe malaria in Tanzania.
Manjurano, A.; Sepúlveda, N.; Nadjm, B.; Mtove, G.; Wangai, H.; Maxwell, C.; Olomi, R.; Reyburn, H.; Drakeley, C.J.; Riley, E.M.; Clark, T.G.; in Collaboration With MalariaGEN, .;
J Infect Dis
Imputation-Based Population Genetics Analysis of Plasmodium falciparum Malaria Parasites.
Samad, H. ; Coll, F. ; Preston, M.D. ; Ocholla, H. ; Fairhurst, R.M. ; Clark, T.G. ;
PLoS Genet
A transcriptional switch underlies commitment tosexual development in malaria parasites
Kafsack, B.F.; Rovira-Graells, N.; Clark, T.G.; Bancells, C.; Crowley, V.M.; Campino, S.G.; Williams, A.E.; Drought, L.G.; Kwiatkowski, D.P.; Baker, D.A.; Cortés, A.; Llinás, M.;
Nature
A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.
Preston, M.D.; Campino, S.; Assefa, S.A.; Echeverry, D.F.; Ocholla, H.; Amambua-Ngwa, A.; Stewart, L.B.; Conway, D.J.; Borrmann, S.; Michon, P.; Zongo, I.; Ouédraogo, J.B.; Djimde, A.A.; Doumbo, O.K.; Nosten, F.; Pain, A.; Bousema, T.; Drakeley, C.J.; Fairhurst, R.M.; Sutherland, C.J.; Roper, C.; Clark, T.G.;
Nat Commun
A robust SNP barcode for typing Mycobacterium tuberculosis complex strains.
Coll, F. ; McNerney, R. ; Guerra-Assunção, J.A. ; Glynn, J.R. ; Perdigão, J. ; Viveiros, M. ; Portugal, I. ; Pain, A. ; Martin, N. ; Clark, T.G. ;
Nat Commun
See all Professor Taane Clark's Publications