Christian Bottomley


Associate Professor
(Medical Statistics and Epidemiology)


Keppel Street
United Kingdom

020 7927 2533

I obtained a PhD in mathematical biology from University College London (UCL) in 2006. Since then I have worked as a medical statistician in the Department of Primary Care and Population Sciences at UCL, before joining the Tropical Epidemiology Group in June 2008.


Department of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health


Centre for Evaluation
Mathematical Modelling of Infectious Diseases
Statistical Methodology
Vaccine Centre


I am a course organizer for Design and Analysis of Epidemiological Studies (DANES) and  teach on the courses Statistics for Epidemiology and Public Health (STEPH), and Advanced Statistical Methods in Epidemiology (ASME).


My research interests are in statistics, mathematical modelling and epidemiology.

I collaborate with investigators in The Gambia and Kenya on studies to evaluate the introduction of pneumococcal conjugate vaccines into the routine childhood vaccination schedule.

Currently I am also the principle statistician for a trial in which antibiotics are being given to women in labour with the aim of reducing bacterial transmission to infants (PregnAnZI).

Research Area
Clinical trials
Complex interventions
Statistical methods
Mathematical modelling
Disease and Health Conditions
Infectious disease

Selected Publications

Can the buck always be passed to the highest level of clustering?
Bottomley, C. ; Kirby, M.J. ; Lindsay, S.W. ; Alexander, N. ;
BMC Med Res Methodol
Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings.
Bottomley, C. ; Isham, V. ; Vivas-Martínez, S. ; Kuesel, A.C. ; Attah, S.K. ; Opoku, N.O. ; Lustigman, S. ; Walker, M. ; Basáñez, M.G. ;
Parasit Vectors
Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial.
Mfinanga, S. ; Chanda, D. ; Kivuyo, S.L. ; Guinness, L. ; Bottomley, C. ; Simms, V. ; Chijoka, C. ; Masasi, A. ; Kimaro, G. ; Ngowi, B. ; Kahwa, A. ; Mwaba, P. ; Harrison, T.S. ; Egwaga, S. ; Jaffar, S. ; REMSTART trial team, . ; COLLABORATORS;Chale, P. ; Kigocha, O. ; Shirima, R.P. ; Lema, Y. ; Kasubi, M. ; Mathania, M. ; Makuchilo, M. ; Mziray, F. ; Alway, C. ; Rwezaura, L. ; Mgohamwenda, J. ; Minde, J. ; Luhimbo, T. ; Biseko, M. ; Kapesa, E. ; Shoo, W. ; Barankena, A. ; Mzyece, J. ; Chanda, R. ; Salim, E. ; Kashongore, G. ; Kapotwe, V. ; Manan, D. ;
Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies.
Ngugi, A.K.; Bottomley, C.; Kleinschmidt, I.; Wagner, R.G.; Kakooza-Mwesige, A.; Ae-Ngibise, K.; Owusu-Agyei, S.; Masanja, H.; Kamuyu, G.; Odhiambo, R.; Chengo, E.; Sander, J.W.; Newton, C.R.; SEEDS group, .;
Lancet Neurol
A mathematical model of serotype replacement in pneumococcal carriage following vaccination.
Bottomley, C. ; Roca, A. ; Hill, P.C. ; Greenwood, B. ; Isham, V. ;
J R Soc Interface
Effect of two different house screening interventions on exposure to malaria vectors and on anaemia in children in The Gambia: a randomised controlled trial
Kirby, M.J.; Ameh, D.; Bottomley, C.; Green, C.; Jawara, M.; Milligan, P.J.; Snell, P.C.; Conway, D.J.; Lindsay, S.W.
See all Christian Bottomley's Publications