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Christian Bottomley

PhD

Associate Professor
(Medical Statistics and Epidemiology)

Room
G12

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I obtained a PhD in mathematical biology from University College London (UCL) in 2006. Since then I have worked as a medical statistician in the Department of Primary Care and Population Sciences at UCL, before joining the International Statistics and Epidemiology Group in June 2008.

Affiliations

Department of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health

Centres

Centre for Evaluation
Centre for the Mathematical Modelling of Infectious Diseases (CMMID)
Centre for Statistical Methodology
Vaccine Centre

Teaching

I am a course organizer for the module Design and Analysis of Epidemiological Studies, and also a tutor on the Epidemiology MSc and Clinical Trials MSc.

Research

My research interests are in applied statistics and infectious disease epidemiology.

I collaborate with investigators in The Gambia and Kenya on studies to evaluate the introduction of pneumococcal conjugate vaccines into the routine childhood vaccination schedule. Through these collaborations I have become interested in evaluating vaccines and other interventions using interrupted time series analyses.

I am also the principle statistician for several ongoing trials, including a cluster-randomsied trial of a hospital management intervention in Malawi, a trial of fractional dose pneumococcal vaccine in Kenya, and a trial of intra-partum azithromycin in The Gambia and Burkina Faso.

Research Area
Clinical trials
Complex interventions
Statistical methods
Vaccines
Modelling
Discipline
Epidemiology
Mathematical modelling
Statistics
Disease and Health Conditions
Infectious disease
Country
The Gambia
Kenya

Selected Publications

Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death: A Randomized Clinical Trial.
Roca A; Camara B; Bognini JD; Nakakana UN; Somé AM; Beloum N; Rouamba T; Sillah F; Danso M; Jones JC
2023
JAMA
Quantifying previous SARS-CoV-2 infection through mixture modelling of antibody levels.
Bottomley C; Otiende M; Uyoga S; Gallagher K; Kagucia EW; Etyang AO; Mugo D; Gitonga J; Karanja H; Nyagwange J
2021
Nature communications
Analysing Interrupted Time Series with a Control
Bottomley C; Scott JAG; Isham V
2019
Epidemiologic Methods
Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea.
Marks M; Mitjà O; Bottomley C; Kwakye C; Houinei W; Bauri M; Adwere P; Abdulai AA; Dua F; Boateng L
2018
The Lancet Global health
Housing Improvements and Malaria Risk in Sub-Saharan Africa: A Multi-Country Analysis of Survey Data.
Tusting LS; Bottomley C; Gibson H; Kleinschmidt I; Tatem AJ; Lindsay SW; Gething PW
2017
PLoS medicine
Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings.
Bottomley C; Isham V; Vivas-Martínez S; Kuesel AC; Attah SK; Opoku NO; Lustigman S; Walker M; Basáñez M-G
2016
Parasites & vectors
Can the buck always be passed to the highest level of clustering?
Bottomley C; Kirby MJ; Lindsay SW; Alexander N
2016
BMC medical research methodology
Oral azithromycin given during labour decreases bacterial carriage in the mothers and their offspring: a double-blind randomized trial.
Roca A; Oluwalana C; Bojang A; Camara B; Kampmann B; Bailey R; Demba A; Bottomley C; D'Alessandro U
2016
Clinical microbiology and infection
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