Christian Bottomley

PhD

Associate Professor

(Medical Statistics and Epidemiology)

Room

G12

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I obtained a PhD in mathematical biology from University College London (UCL) in 2006. Since then I have worked as a medical statistician in the Department of Primary Care and Population Sciences at UCL, before joining the Tropical Epidemiology Group in June 2008.

Affiliations

Faculty of Epidemiology and Population Health

Department of Infectious Disease Epidemiology

Centres

Centre for Evaluation

Mathematical Modelling of Infectious Diseases

Statistical Methodology

Vaccine Centre

Teaching

I am a course organizer for Design and Analysis of Epidemiological Studies (DANES) and teach on the courses Statistics for Epidemiology and Public Health (STEPH), and Advanced Statistical Methods in Epidemiology (ASME).

Research

My research interests are in statistics, mathematical modelling and epidemiology.

I collaborate with investigators in The Gambia and Kenya on studies to evaluate the introduction of pneumococcal conjugate vaccines into the routine childhood vaccination schedule.

Currently I am also the principle statistician for a trial in which antibiotics are being given to women in labour with the aim of reducing bacterial transmission to infants (PregnAnZI).

Research Area

Clinical trials

Complex interventions

Statistical methods

Vaccines

Modelling

Discipline

Epidemiology

Mathematical modelling

Statistics

Disease and Health Conditions

Infectious disease

Country

Gambia, The

Kenya

Selected Publications

Can the buck always be passed to the highest level of clustering?

Bottomley, C. ; Kirby, M.J. ; Lindsay, S.W. ; Alexander, N. ;

2016

BMC Med Res Methodol

Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings.

Bottomley, C. ; Isham, V. ; Vivas-Martínez, S. ; Kuesel, A.C. ; Attah, S.K. ; Opoku, N.O. ; Lustigman, S. ; Walker, M. ; Basáñez, M.G. ;

2016

Parasit Vectors

Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial.

Mfinanga, S. ; Chanda, D. ; Kivuyo, S.L. ; Guinness, L. ; Bottomley, C. ; Simms, V. ; Chijoka, C. ; Masasi, A. ; Kimaro, G. ; Ngowi, B. ; Kahwa, A. ; Mwaba, P. ; Harrison, T.S. ; Egwaga, S. ; Jaffar, S. ; REMSTART trial team, . ; COLLABORATORS;Chale, P. ; Kigocha, O. ; Shirima, R.P. ; Lema, Y. ; Kasubi, M. ; Mathania, M. ; Makuchilo, M. ; Mziray, F. ; Alway, C. ; Rwezaura, L. ; Mgohamwenda, J. ; Minde, J. ; Luhimbo, T. ; Biseko, M. ; Kapesa, E. ; Shoo, W. ; Barankena, A. ; Mzyece, J. ; Chanda, R. ; Salim, E. ; Kashongore, G. ; Kapotwe, V. ; Manan, D. ;

2015

Lancet

Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies.

Ngugi, A.K.; Bottomley, C.; Kleinschmidt, I.; Wagner, R.G.; Kakooza-Mwesige, A.; Ae-Ngibise, K.; Owusu-Agyei, S.; Masanja, H.; Kamuyu, G.; Odhiambo, R.; Chengo, E.; Sander, J.W.; Newton, C.R.; SEEDS group, .;

2013

Lancet Neurol

A mathematical model of serotype replacement in pneumococcal carriage following vaccination.

Bottomley, C. ; Roca, A. ; Hill, P.C. ; Greenwood, B. ; Isham, V. ;

2013

J R Soc Interface

Effect of two different house screening interventions on exposure to malaria vectors and on anaemia in children in The Gambia: a randomised controlled trial

Kirby, M.J.; Ameh, D.; Bottomley, C.; Green, C.; Jawara, M.; Milligan, P.J.; Snell, P.C.; Conway, D.J.; Lindsay, S.W.

2009

Lancet

Rates of microfilarial production by Onchocerca volvulus are not cumulatively reduced by multiple ivermectin treatments.

Bottomley, C.; Isham, V.; Collins, R.C.; Bas??ez, M.G.;