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Dr David Allen

PhD

Associate Professor
of Virology

Room
362A

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7612 7873

I studied for my BSc in Virology and Immunology at the University of Warwick, then completed my PhD working jointly at the London School of Hygiene and Tropical Medicine and the Health Protection Agency (now Public Health England).

Following this, I worked with the Medical Research Council, and then returned to the Health Protection Agency/Public Health England, where I was Head of the Enteric Virus Unit.

I have worked with national and international public health agencies, including the World Health Organization, with the Global Polio Laboratory Network.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

Vaccine Centre

Teaching

I am involved in the MSc in Medical Microbiology, as Deputy Module Organiser and amd part of the Programme Committee for this MSc programme.

I am a Module Organiser, and teach on 3121 Core Virology, 3187 Clinical Virology, and 3140 Molecular Viology modules.

I am a tutor for the Infectious Diseases (Distance Learning) course module Viral Infections (DL).

Research

My research interests are in enteric virus infections - particularly norovirus and enterovirus - and the virological features of these viruses that drive their highly dynamic epidemiology, allowing them to emerge and persist in human populations.

Enteric virus infections associated with gastroenteritis are common among humans. Whilst illness is usually mild and self-limiting, viral gastroenteritis causes substantial morbidity in the population: in particular, that associated with norovirus which has an estimated incidence in the UK community of three million cases each year. The plasticity of the norovirus genome and error-prone nature of its replication allows for the generation of genetically diverse populations of viruses that co-circulate, and selective pressure drives selection and the periodic emergence of novel strains.

My current research interests are focused in two main areas:

(1) evolution of the antigenic profile of a virus under selective pressure of host and population (herd) immunity; and

(2) the virus-host interactions made during the early stages of infection.

Currently, I am a co-investigator on a Wellcome Trust-funded collaborative project (with University College London, University of Liverpool and University of North Carolina), which will look at understanding the emergence of pandemic norovirus strains.

I am a collaborator in the NIHR Health Protection Research Unit in Gastrointestinal Infections, working on the Places Theme.

I am also a collaborator on a Food Standards Agency-funded project looking at assessing the contribution made by the food chain to the burden of UK-acquired norovirus infection (NoVAS project).

 

Vist the Allen Laboratory webpage: www.allenlabvirology.com

Research Area
Diagnostics
Public health
Surveillance
Viruses
Disease control
Outbreaks
Discipline
Genomics
Molecular epidemiology
Molecular biology
Virology
Disease and Health Conditions
Diarrhoeal diseases
Infectious disease
Neurological disease
Pandemic diseases
Emerging Infectious Disease
Country
United Kingdom

Selected Publications

Surveillance Optimization to Detect Poliovirus in the Pre-Eradication Era: a Modelling Study of England and Wales.
O'Reilly KM; Grassly NC; Allen DJ; Bannister-Tyrrell M; Cameron A; Carrion Martin AI; Ramsay M; Pebody R; Zambon M
2020
Epidemiology and Infection
Impact of rotavirus vaccination on rotavirus genotype distribution and diversity in England, September 2006 to August 2016.
Hungerford D; Allen DJ; Nawaz S; Collins S; Ladhani S; Vivancos R; Iturriza-Gómara M
2019
Eurosurveillance
Challenges of investigating a large food-borne norovirus outbreak across all branches of a restaurant group in the United Kingdom, October 2016.
Morgan M; Watts V; Allen D; Curtis D; Kirolos A; Macdonald N; Maslen E; Morgan D; Saei A; Sedgwick J
2019
Eurosurveillance
An interactive data visualisation application to investigate nosocomial transmission of infections.
Smith CM; Allen DJ; Nawaz S; Kozlakidis Z; Nastouli E; Hayward A; Ward KN
2019
Wellcome Open Research
Effectiveness of oral rotavirus vaccination in England against rotavirus-confirmed and all-cause acute gastroenteritis.
Walker JL; Andrews NJ; Atchison CJ; Collins S; Allen DJ; Ramsay ME; Ladhani SN; Thomas SL
2019
Vaccine: X
Comparing the Clinical Severity of Disease Caused by Enteroviruses and Human Parechoviruses in Neonates and Infants.
Black S; Bradley C; Lai FY; Shenoy S; Bandi S; Allen DJ; Tang JW
2018
The Pediatric infectious disease journal
Increased detection of human parechovirus infection in infants in England during 2016: epidemiology and clinical characteristics.
Ferreras Antolín L; Kadambari S; Braccio S; Tang JW-T; Xerry J; Allen DJ; Ladhani SN; Parechovirus Surveillance Network
2018
Archives of disease in childhood
Recommendations for enterovirus diagnostics and characterisation within and beyond Europe.
Harvala H; Broberg E; Benschop K; Berginc N; Ladhani S; Susi P; Christiansen C; McKenna J; Allen D; Makiello P
2018
Journal of clinical virology
Isolation of Vaccine-Like Poliovirus Strains in Sewage Samples From the United Kingdom.
Majumdar M; Klapsa D; Wilton T; Akello J; Anscombe C; Allen D; Mee ET; Minor PD; Martin J
2018
The Journal of Infectious Diseases
Influence of Nonpolio Enteroviruses and the Bacterial Gut Microbiota on Oral Poliovirus Vaccine Response: A Study from South India.
Praharaj I; Parker EPK; Giri S; Allen DJ; Silas S; Revathi R; Kaliappan SP; John J; Prasad JH; Kampmann B
2018
The Journal of infectious diseases
Molecular surveillance of norovirus, 2005-16: an epidemiological analysis of data collected from the NoroNet network.
van Beek J; de Graaf M; Al-Hello H; Allen DJ; Ambert-Balay K; Botteldoorn N; Brytting M; Buesa J; Cabrerizo M; Chan M
2018
The Lancet infectious diseases
Methods for ascertaining norovirus disease burdens.
Allen DJ; Harris JP
2017
Human vaccines & immunotherapeutics
The emergence of enterovirus D68 in England in autumn 2014 and the necessity for reinforcing enterovirus respiratory screening.
Carrion Martin AI; Pebody RG; Danis K; Ellis J; Niazi S; DE Lusignan S; Brown KE; Zambon M; Allen DJ
2017
Epidemiology and infection
An outbreak of norovirus GI-6 infection following a wedding in North West England.
Smith KC; Inns T; Decraene V; Fox A; Allen DJ; Shah A
2017
Epidemiology and infection
Antibodies against Lewis antigens inhibit the binding of human norovirus GII.4 virus-like particles to saliva but not to intestinal Caco-2 cells.
Carmona-Vicente N; Allen DJ; Rodríguez-Díaz J; Iturriza-Gómara M; Buesa J
2016
Virology journal
Characterization of a Novel Conformational GII.4 Norovirus Epitope: Implications for Norovirus-Host Interactions.
Carmona-Vicente N; Vila-Vicent S; Allen D; Gozalbo-Rovira R; Iturriza-Gómara M; Buesa J; Rodríguez-Díaz J
2016
Journal of virology
Emergence of the GII-4 Norovirus Sydney2012 strain in England, winter 2012-2013.
Allen DJ; Adams NL; Aladin F; Harris JP; Brown DWG
2014
PloS one
Molecular evolution of GII-4 Norovirus strains.
Zakikhany K; Allen DJ; Brown D; Iturriza-Gómara M
2012
PloS one
See more Publications