Sedona's primary research interest lies in the economic impact of substantial long-term health shocks, examined both at the provider level and within the household. Her work sits at the intersection of rigorous health economics methodology and real-world global health policy relevance, spanning high- and low/middle-income country contexts.

At the provider level, Sedona leads work on economic evaluation methods and cost data collection across a wide range of areas, including new TB drug regimens (TB PRACTECAL), adherence technology, approaches to finding people with TB, and integrated care. She has shaped methods for cost data collection in TB and HIV through projects such as the Global Health Cost Consortium and Value TB, and is currently informing the use of cost functions and their application to models through TB MAC and CAPTURE. She has also led on economic evaluations of services for vulnerable individuals in the UK. 

At the household level, Sedona is interested in how poverty dynamics unfold over time and how families cope with health shocks. She has led studies evaluating the catastrophic costs incurred by households living with chronic illness — including TB and HIV — and has contributed to methodological advances in measuring poverty and costs in low- and middle-income country settings.