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Immunometabolism and circadian rhythmicity

It has become clear, over the last ten years or so, that there is a strong correlation between cell metabolism and immune cells effector function, hence the relatively new concept of “immunometabolism”. In this regard, as an example, naïve T lymphocytes that rely mostly on oxidative phosphorylation (OXPHOS) increase the expression of the glucose transporter glut-1 as well as of key glycolysis enzymes following activation, thus increasing glucose uptake and glycolysis rate. In addition, some of the glycolysis enzymes have immunoregulatory properties.

On the other hand, there is increasing evidence that some immune responses depend on time of the day i.e., they follow a circadian rhythm pattern.

Since there is a strong correlation between metabolism and circadian rhythmicity, it follows that there is a close cross-talk between circadian rhythmicity, metabolism, and immune response.

We will briefly explore current literature, recent work from the lab back in Mexico, as well as work still in progress at LSHTM, on this topic. In particular, some metabolic aspects of neutrophil and monocyte/macrophage function.


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