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Seminar

Immune-endocrine interactions at the intestinal barrier

The intestinal epithelium offers the first interaction between commensal bacteria, pathogens and our bodies’ largest immune system. Inappropriate immune responses drive inflammatory bowel disease (IBD) or excessive inflammation during infection. John's research focuses on the epithelial enteroendocrine cells (EECs), which release peptide hormones in response to nutrients allowing their efficient digestion. EEC alterations are strongly associated with inflammation and infection, yet the possibility of interactions between our gut’s endocrine and immune systems remains overlooked.  He utilizes intestinal infection models as well as in vitro studies to dissect the mechanistic interaction between these diverse systems to potentially inform new EEC-derived therapeutic strategies for inflammatory diseases of the intestine.

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