Dissecting transcription regulatory networks in malaria parasites
The malaria parasite passes through a succession of over ten different life forms and has to adapt to new hosts and conditions along the way. These transitions involve extensive remodelling of the parasite cell and require changes in the expression of many genes. Potential key regulators of the adaption to the new conditions are the apicomplexa AP2 proteins (apiAP2), with different ApiAP2 proteins acting at different stages of the lifecycle. My lab focuses on the transcriptional changes that occur when the parasite moves from the vertebrate host to the mosquito host, with the aim to understand how these changes allow the parasite to thrive in the new environment.