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Development of Plasmodium knowlesi species specific reagents to help characterise antibody isotype profiles in endemic human populations and experimental macaque infections

Plasmodium knowlesi is the most common cause of malaria in Malaysian Borneo, with reporting limited to clinical cases presenting to health facilities and scarce data on the true extent of transmission. There is a distinct lack of suitable serosurveillance tools for this emerging neglected disease. Using in silico tools, we designed and expressed a panel of P. knowlesi protein products to address this deficit and have successfully tested these using the ELISA, Multiplex Bead Assay (MBA) and Protein Microarray on a sample set of clinical and endemic samples from Malaysia and experimental Rhesus macaques, determining the reactivity profiles of IgM, IgG and IgA.

 

 

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