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Mr Ludoviko Zirimenya

Research Fellow

MRC/UVRI & LSHTM Uganda Research Unit
Plot 51-59 Nakiwogo Road
Entebbe
Uganda

I am a physician and research scientist specializing in vaccine epidemiology. My work focuses on understanding how different populations in Africa respond to commonly used vaccines. I am particularly fascinated by the diverse responses to vaccines and the non-specific (beneficial) effects they may have. My research seeks to answer questions such as how environmental exposures, like malaria, affect vaccine responses and how BCG re-immunization might serve as a tool to enhance the benefits of other vaccines

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I contribute to teaching by serving as a tutor for distance learning modules, and engaging students in an interactive and supportive virtual environment. On campus at the Uganda Unit, I facilitate training sessions for staff and researchers, helping to enhance their skills and knowledge.

Research

My research interests focus on vaccine epidemiology, particularly in understanding how different African populations respond to commonly used vaccines. I am intrigued by the variability in immune responses and the non-specific beneficial effects of vaccines. I aim to explore how environmental exposures, such as malaria, impact vaccine efficacy and investigate the potential of BCG re-immunization to enhance the benefits of other vaccines. My work seeks to improve vaccine strategies and public health outcomes by understanding these complex interactions.

Research Area
Epidemiology
Immunisation
Immunity
Serology, vaccines
Disease and Health Conditions
Malaria
COVID-19
Tuberculosis
Country
Uganda
Kenya
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Life Course Malaria Exposure and SARS-CoV-2 Seroepidemiology in Ugandan Adolescents: A Longitudinal Study Nested in a Birth Cohort.
ZIRIMENYA, L; Nayebare, D; Baine, C; Nassuuna, J; Namutebi, M; Zziwa, C; Nsubuga, D; Kiwudhu, F; Akello, F; Tumusiime, J; Oduru, G; Kabami, G; Akurut, H; Nakyesige, R; Natukunda, A; WAJJA, A; Lubyayi, L; Kimuda, S; NKURUNUNGI, G; Serwanga, J; Doores, KJ; WEBB, EL; ELLIOTT, AM;
2026
Tropical medicine & international health : TM & IH
Data for: "Effect of malaria intermittent preventive treatment on SARS-CoV-2 seroprevalence and response to COVID-19 vaccination: longitudinal study nested within a randomised controlled trial"
ZIRIMENYA, L; Nassuuna, J; Nayebare, D; Baine, C; Namutebi, M; Zziwa, C; Nsubuga, D; Oduru, G; Akello-Ateng, F; Ninsiima, C; Mutebe, A; Wajja, A; Kimuda, S; Natukunda, A; NKURUNUNGI, G; Serwanga, J; ELLIOTT, A; WEBB, E;
2026
London School of Hygiene & Tropical Medicine
Mapping Community Vulnerability to reduced Vaccine Impact in Uganda and Kenya: A spatial Data-driven Approach.
NALWANGA, R; Natukunda, A; ZIRIMENYA, L; Chi, P; Luzze, H; ELLIOTT, AM; KALEEBU, P; Trotter, CL; WEBB, EL;
2025
NIHR open research
Temporal trends of SARS-CoV-2 exposure in adolescents: a longitudinal pilot study nested in a Uganda birth cohort.
ZIRIMENYA, L; Nassuuna, J; Namutebi, M; Zziwa, C; Serubanja, J; Nsubuga, D; Kiwudhu, F; Akello, F; Tumusiime, J; Ninsiima, C; Oduru, G; Kabami, G; Akurut, H; Nakyesige, R; Kimuda, S; WAJJA, A; NKURUNUNGI, G; SERWANGA, J; Doores, KJ; WEBB, EL; ELLIOTT, AM;
2025
NIHR open research
Exploring interrelationships between structural, social, and biological determinants of vaccine impact in Kenya and Uganda: VAnguard community mixed methods study protocol
Etyang, T; ZIRIMENYA, L; Njue, M; NALWANGA, R; Zalwango, F; Abuga, KM; Karanja, HK; Mumba, N; Owino, EA; Eoju, W; Kukundakwe, C; Nsubuga, D; Baine, C; Walusimbi, B; NKURUNUNGI, G; Natukunda, A; Chibita, M; Mafigiri, DK; Kamuya, D; Atkinson, S; Chi, P; WEBB, EL; Trotter, CL; Kaleebu, P; ELLIOTT, AM;
2025
NIHR open research
Data supporting "Temporal trends of SARS-CoV-2 exposure in adolescents: a longitudinal pilot study nested in a Uganda birth cohort"
ZIRIMENYA, L; Natukunda, A; Nassuna, J; NKURUNUNGI, G; ELLIOTT, AM; WEBB, E;
2025
London School of Hygiene & Tropical Medicine
Helminth driven gut inflammation and microbial translocation associate with altered vaccine responses in rural Uganda.
Nassuuna, J; Sterk, J; Walusimbi, B; Natukunda, A; Nkangi, R; Amongin, R; ZIRIMENYA, L; WEBB, EL; ELLIOTT, AM; NKURUNUNGI, G;
2025
NPJ Vaccines
Assessing community vulnerability to reduced vaccine impact in Uganda and Kenya: A spatial data analysis
NALWANGA, R; Natukunda, A; ZIRIMENYA, L; Chi, P; Luzze, H; ELLIOTT, AM; Kaleebu, P; Trotter, CL; WEBB, EL;
2025
NIHR open research
The effect of BCG revaccination on the response to unrelated vaccines in urban Ugandan adolescents (POPVAC C): an open-label, randomised controlled trial.
Nassuuna, J; ZIRIMENYA, L; NKURUNUNGI, G; Natukunda, A; Zziwa, C; Ninsiima, C; Apule, B; Onen, C; Amongi, S; Serubanja, J; Tumwesige, P; Nsubuga, D; Amongin, R; Van Dam, GJ; Corstjens, PL A M; Kayiwa, J; Kabagenyi, J; COSE, S; WAJJA, A; KALEEBU, P; WEBB, EL; ELLIOTT, AM; POPVAC trial team,;
2024
The Lancet Global health
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