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Dr Weining Wu

Research Fellow

United Kingdom

Jump to: Affiliations Research Publications
I have a virology background and have been working with a couple of different RNA viruses. My research interest is to understand the virus-host interaction and underlying mechanism using a series of molecular biology methods.

Affiliations
Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Research
My research focuses on the Bluetongue virus (BTV) entry and egress. I am trying to understand both processes at molecular level using various techniques, such as reverse genetics, immunofluorescence, electron microscopy etc. This helps us to deep understand the virus life cycle and virus-host interaction and to develop potential antivirals.

Selected Publications
Insect-borne non-enveloped bluetongue virus utilizes discrete small vesicles for non-lytic release and cell-to-cell transmission.
WU, W; Laugks, U; Grünewald, K; Roy, P;
2025
PLoS pathogens
SARS-CoV-2 Virus-like Particles Produced by a Single Recombinant Baculovirus Generate Anti-S Antibody and Protect against Variant Challenge.
Sullivan, E; SUNG, P-Y; WU, W; Berry, N; Kempster, S; Ferguson, D; Almond, N; Jones, IM; ROY, P;
2022
Viruses
Bluetongue virus capsid protein VP5 perforates membranes at low endosomal pH during viral entry.
Xia, X; WU, W; Cui, Y; ROY, P; Zhou, ZH;
2021
Nat Microbiol
Sialic Acid Binding Sites in VP2 of Bluetongue Virus and Their Use during Virus Entry.
WU, W; ROY, P;
2021
Journal of virology
Mapping the pH Sensors Critical for Host Cell Entry by a Complex Nonenveloped Virus.
WU, W; Celma, CC; KERVIEL, A; ROY, P;
2018
Journal of virology
Elucidation of the Cellular Interactome of Ebola Virus Nucleoprotein and Identification of Therapeutic Targets.
García-Dorival, I; WU, W; Armstrong, SD; Barr, JN; Carroll, MW; HEWSON, R; Hiscox, JA;
2016
Journal of proteome research
Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication.
Dong, S; Liu, L; WU, W; Armstrong, SD; Xia, D; Nan, H; Hiscox, JA; Chen, H;
2016
Journal of proteomics
Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach.
Aljabr, W; Touzelet, O; Pollakis, G; WU, W; Munday, DC; Hughes, M; Hertz-Fowler, C; Kenny, J; Fearns, R; Barr, JN; Matthews, DA; Hiscox, JA;
2016
Journal of virology
Characterization of the Interactome of the Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Reveals the Hyper Variable Region as a Binding Platform for Association with 14-3-3 Proteins.
Xiao, Y; WU, W; Gao, J; Smith, N; Burkard, C; Xia, D; Zhang, M; Wang, C; Archibald, A; Digard, P; Zhou, E-M; Hiscox, JA;
2016
Journal of proteome research
Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β.
Bakre, A; WU, W; Hiscox, J; Spann, K; Teng, MN; Tripp, RA;
2015
The Journal of general virology
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Contact

United Kingdom