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Professor Deborah Watson-Jones

BMBCh MRCP DTM&H MSc PhD

Professor
(Clinical)

Mwanza Intervention Trials Unit
National Institute for Medical Research
Mwanza
P.O. Box 11936
United Kingdom

Tel.
+255 754 056066 / +44 207927 2958

Fax.
+255 28 2500019

Debby Watson-Jones is a Clinical Epidemiologist who has lived and worked in Kenya, Nigeria, Senegal, India, Mongolia and Tanzania. She has worked for LSHTM since 1995 and is currently based in Tanzania and Ethiopia.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Maternal, Adolescent, Reproductive & Child Health (MARCH)
Vaccine Centre

Teaching

She is the co-organiser of Control of Reproductive Tract Infections Module (3192) and has taught on the HIV and STD component of MSc in Control of Infectious Diseases and on Foundations in Reproductive Health, Safe Motherhood and the AIDS study units and on HIV/STD Control in Conflicts for the Health in Complex Emergencies Course. She also teaches on the Vaccinology in Africa course in Entebbe.

Research

Her main research interest is the development and evaluation of interventions to control Ebola, HPV, HIV and other sexually transmitted infections in sub-Saharan Africa. She is currently leading EBOVAC1, a multisite project that is implementing several clinical trials to evaluate the Ad26.ZEBOV MVA BN Filo prime boost vaccine to prevent Ebola infection, with trial sites in Sierra Leone, Kenya, Tanzania and Uganda. She is also leading the DoRIS trial to evaluate immunogenicity and safety of one dose of HPV vaccine in Tanzania.

Recently completed studies include a project to collate lessons learnt from HPV vaccine demonstration projects in low and middle income countries and studies on HPV epidemiology, other STIs and the vaginal microbiome around sexual debut in Tanzania. She has been involved in a trial of different contact tracing strategies for Ebola and a trial of combination HIV prevention, including immediate lifelong ART in HIV infected individuals, in Zambia and South Africa (the PopART HPTN-071 trial). Previous studies include a trial to compare different HPV vaccine delivery strategies in Tanzania; a phase IIIb immunogenicity and safety trial of the bivalent HPV vaccine in young African women; HPV vaccine acceptability in hard-to-reach populations in Kenya, PMTCT performance in East Africa, interventions against HSV-2 to prevent HIV infection, syphilis in pregnancy, hydatid disease in Kenya and Mongolia and HIV/STD control in large-scale goldmines and neighbouring communities in the Lake Victoria Goldfields. She was the LSHTM research team leader in Mwanza from 2003-2007.

She is an advisory committee member on one dose HPV vaccine trials and HPV therapeutic vaccines. She was a member of the UK DOH Expert Panel on the prime boost vaccine, the LSHTM Ebola task force, the GAVI Alliance Independent Review Committee, the WHO  Committee for the revision of guidelines for comprehensive cancer control (C4-GEP) and a temporary advisor for the WHO HPV Vaccine Advisory Committee.

 

 

Research Area
Clinical trials
Sexual health
Vaccines
Adolescent health
Randomised controlled trials
Reproductive health
Discipline
Epidemiology
Medicine
Vaccinology
Disease and Health Conditions
Syphilis
Cancer
Herpesviruses
HIV/AIDS
Sexually transmitted disease
Cervical cancer
Emerging Infectious Disease
Human papillomavirus (HPV)
Sexually transmitted infection
Zoonotic disease
Country
Kenya
Sierra Leone
Tanzania
Uganda
South Africa
Zambia
Region
Sub-Saharan Africa (developing only)

Selected Publications

The association between cervical human papillomavirus infection and subsequent HIV acquisition in Tanzanian and Ugandan women: a nested case-control study.
Gallagher, K.E.; Baisley, K.; Grosskurth, H.; Vallely, A.; Kapiga, S.; Vandepitte, J.; Kamali, A.; De Sanjosé, S.; Changalucha, J.; Hayes, R.; Watson-Jones, D.;
J Infect Dis
The value of demonstration projects for new interventions: the case of human papillomavirus vaccine introduction in low and middle-income countries.
Howard, N.; Mounier-Jack, S.; Gallagher, K.E.; Kabakama, S.; Griffiths, U.K.; Feletto, M.; LaMontagne, D.S.; Burchett, H.E.; Watson-Jones, D.;
Hum Vaccin Immunother
Power, fairness and trust: understanding and engaging with vaccine trial participants and communities in the setting up the EBOVAC-Salone vaccine trial in Sierra Leone.
Enria, L. ; Lees, S. ; Smout, E. ; Mooney, T. ; Tengbeh, A.F. ; Leigh, B. ; Greenwood, B. ; Watson-Jones, D. ; Larson, H. ;
BMC Public Health
Impact of malaria and helminth infections on immunogenicity of the human papillomavirus-16/18 AS04-adjuvanted vaccine in Tanzania.
Brown, J.; Baisley, K.; Kavishe, B.; Changalucha, J.; Andreasen, A.; Mayaud, P.; Gumodoka, B.; Kapiga, S.; Hayes, R.; Watson-Jones, D.;
Vaccine
Safety and Immunogenicity of Human Papillomavirus-16/18 AS04-Adjuvanted Vaccine: A Randomized Trial in 10-25-Year-Old HIV-Seronegative African Girls and Young Women.
Sow, P.S.; Watson-Jones, D.; Kiviat, N.; Changalucha, J.; Mbaye, K.D.; Brown, J.; Bousso, K.; Kavishe, B.; Andreasen, A.; Toure, M.; Kapiga, S.; Mayaud, P.; Hayes, R.; Lebacq, M.; Herazeh, M.; Thomas, F.; Descamps, D.;
J Infect Dis
High prevalence and incidence of human papillomavirus in a cohort of healthy young African female subjects.
Watson-Jones, D.; Baisley, K.; Brown, J.; Kavishe, B.; Andreasen, A.; Changalucha, J.; Mayaud, P.; Kapiga, S.; Gumodoka, B.; Hayes, R.J.; de Sanjosé, S.;
Sex Transm Infect
HPV vaccination in Tanzanian schoolgirls: cluster-randomised trial comparing two vaccine delivery strategies.
Watson-Jones, D.; Baisley, K.; Ponsiano, R.; Lemme, F.; Remes, P.; Ross, D.; Kapiga, S.; Mayaud, P.; de Sanjosé, S.; Wight, D.; Changalucha, J.; Hayes, R.;
J Infect Dis
Effect of Herpes Simplex Suppression on Incidence of HIV among Women in Tanzania.
Watson-Jones, D.; Weiss, H.A.; Rusizoka, M.; Changalucha, J.; Baisley, K.; Mugeye, K.; Tanton, C.; Ross, D.; Everett, D.; Clayton, T.; Balira, R.; Knight, L.; Hambleton, I.; Le Goff, J.; Belec, L.; Hayes, R.;
N Engl J Med
See all Professor Deborah Watson-Jones's Publications