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Dr Charlene Rodrigues

MBChB (Hons) MRCPCH PGDip Paediatric ID DPhil

Research Fellow
in microbial genomics

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Charlene is a clinical academic, with her research based at LSHTM in microbial genomics and working as a paediatric consultant specialising in infectious diseases at St Mary's Hospital, London. Charlene graduated from medical school (Leicester University) in 2007 and subsequently trained as an NIHR Academic Clinical Fellow (Imperial College London). She completed Paediatric Infectious Diseases/Immunology GRID training (Great North Children's Hospital, Newcastle) with Microbiology (St George's Hospital, London). She has long been interested in genomics, in the context of host and pathogen variation, and undertook a Wellcome Trust funded DPhil in genomic epidemiology (University of Oxford), studying meningococcal vaccine antigens. 

Charlene is working to better integrate genomics and bioinformatic analyses into healthcare settings to ensure they are more accessible to clinicians, microbiologists and epidemiologists to improve patient care.

Charlene's full publications list: ORCID and Google Scholar

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

Antimicrobial Resistance Centre (AMR)

Research

Charlene's research interests are in applications of microbial genomics in the clinical and public health setting to inform preventative and therapeutic measures. Charlene completed a Wellcome Trust funded DPhil, supervised by Prof. Martin Maiden at the University of Oxford (2015-18), in genomic epidemiology of meningococcal vaccine antigens. Charlene developed genomic typing methods (Bexsero Antigen Sequence Typing, Outer Membrane Vesicle Typing) to assess the diversity and distribution of meningococcal vaccine antigens in a national collection of disease-causing meningococci from the UK. These tools along with further translational genomic applications (MenDeVAR Index) are publicly-available via pubmlst.org.

Charlene continues to develop methods to better integrate genomics and bioinformatic analyses in accessible reports for non-genomics specialists in healthcare settings. Her work focusses on reporting of Klebsiella pneumoniae genomic data, as a major cause of neonatal sepsis particularly affecting LMIC, and the associated antimicrobial resistance.

Research Area
Bacteria
Child health
Surveillance
Vaccines
Adolescent health
Immunisation
Neonatal health
Implementation research
Discipline
Genetic epidemiology
Genomics
Molecular epidemiology
Medicine
Microbiology
Disease and Health Conditions
Infectious disease
Meningitis
Hospital acquired infection
Sepsis
Region
East Asia & Pacific (all income levels)
Europe & Central Asia (all income levels)
Latin America & Caribbean (all income levels)
Sub-Saharan Africa (all income levels)

Selected Publications

Impact of meningococcal ACWY conjugate vaccines on pharyngeal carriage in adolescents: evidence for herd protection from the UK MenACWY programme.
Carr JP; MacLennan JM; Plested E; Bratcher HB; Harrison OB; Aley PK; Bray JE; Camara S; Rodrigues CMC; Davis K
2022
Clinical Microbiology and Infection
SARS-CoV-2-specific T-cell responses to recurrent COVID-19 pneumonitis in a patient with post-CART B-cell aplasia.
Hodder A; Williams L; Chu J; Bamford A; Rodrigues C; Gilmour K; Awuah A; Tahami F; Dalton C; McGarrity O
2022
BLOOD ADVANCES
Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci
Chen M; Harrison OB; Bratcher HB; Bo Z; Jolley KA; Rodrigues CMC; Bray JE; Guo Q; Zhang X; Chen M
2021
EMERGING INFECTIOUS DISEASES
Molecular diagnostic assays for the detection of common bacterial meningitis pathogens: A narrative review.
Diallo K; Feteh VF; Ibe L; Antonio M; Caugant DA; du Plessis M; Deghmane A-E; Feavers IM; Fernandez K; Fox LM
2021
EBioMedicine
Treatment of Multisystem Inflammatory Syndrome in Children.
McArdle AJ; Vito O; Patel H; Seaby EG; Shah P; Wilson C; Broderick C; Nijman R; Tremoulet AH; Munblit D
2021
The New England journal of medicine
Case Report: severe paediatric COVID-19 pneumonitis treated with remdesivir and nitazoxanide
Sanchez Clemente N; Pang J; Rodrigues C; Aurora P; Breuer J
2021
Wellcome Open Research
See more Publications