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Dr Alexina Mason

BSc MSc PhD

Assistant Professor
of Medical Statistics

Room
142

LSHTM
15-17 Tavistock Place
London
WC1H 9SH
United Kingdom

Tel.
020 7958 8296

After completing a first degree in Mathematics and Computing (University of Bath), my early career was spent working as an aviation forecaster at the Civil Aviation Authority and National Air Traffic Services. This included a year studying at the University of Sheffield, where I gained an MSc in Statistics. I returned to full-time education in 2005, and completed a PhD on Bayesian methods for modelling non-random missing data mechanisms in longitudinal studies at Imperial. Since then I have worked on the BIAS project, which developed Bayesian methods for integrated bias modelling and analysis of multiple data sources in observational studies, and as a trial statistician in the Imperial Clinical Trials Unit, focussing mainly on critical care trials.

I joined the School in October 2014, and my current research is at the interface of statistics, health economics and decision making, and is aimed at improving Bayesian approaches to healthcare evaluation arising from clinical trials. I have ongoing collaborations with the Intensive Care National Audit and Research Centre (ICNARC), the Statistics for Health Economic Evaluation Group at UCL and the statistical researchers at Imperial College London working in clinical trials.

Affiliations

Department of Health Services Research and Policy
Faculty of Public Health and Policy

Centres

Centre for Statistical Methodology

Teaching

I am a module organiser for Bayesian Statistics for the MSc in Medical Statistics and a seminar leader for Basic Statistics for PHP.

Research

My main research interests revolve around the development and application of Bayesian approaches in clinical trial settings, and in particular to handling missing data. This includes developing methods and tools to facilitate expert elicitation that allows external knowledge to be incorporated into analysis when there is missing or insufficient information from the trial itself.

Research Area
Clinical trials
Bayesian Analysis
Critical care
Discipline
Statistics

Selected Publications

The impact of resuscitation system factors on in-hospital cardiac arrest outcomes across UK hospitals: An observational study.
Couper K; Mason AJ; Gould D; Nolan JP; Soar J; Yeung J; Harrison D; Perkins GD
2020
Resuscitation
Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial.
Lamontagne F; Richards-Belle A; Thomas K; Harrison DA; Sadique MZ; Grieve RD; Camsooksai J; Darnell R; Gordon AC; Henry D
2020
JAMA
A flexible hierarchical framework for improving inference in area-referenced environmental health studies
Pirani M; Mason A; Hansell A; Richardson S; Blangiardo M
2020
Biometrical Journal
Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial.
Antcliffe DB; Santhakumaran S; Orme RML; Ward JK; Al-Beidh F; O'Dea K; Perkins GD; Singer M; McAuley DF; Mason AJ
2019
Intensive care medicine
A framework for extending trial design to facilitate missing data sensitivity analyses.
Mason AJ; Grieve RD; Richards-Belle A; Mouncey PR; Harrison DA; Carpenter JR
2019
BMC medical research methodology
Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials.
Nagendran M; Russell JA; Walley KR; Brett SJ; Perkins GD; Hajjar L; Mason AJ; Ashby D; Gordon AC
2019
Intensive care medicine
Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial.
Peters MJ; Woolfall K; Khan I; Deja E; Mouncey PR; Wulff J; Mason A; Agbeko RS; Draper ES; Fenn B
2019
Critical care (London, England)
Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Statistical and Health Economic Analysis Plan for the 65 trial
Thomas K; Patel A; Sadique MZ; Grieve RD; Mason AJ; Moler S; Gordon AC; Rowan KM; Mouncey PR; Lamontagne F
2019
Journal of the Intensive Care Society
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