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Dr Miguel-Angel Luque

MA MPH MSc PhD

Assistant Professor
of Epidemiology and Biostatistics

Room
259

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I received my Ph.D. in Preventive Medicine (Epidemiology) and Public Health, awarded with Summa Cum Laude, from the University of Granada (UGR, Spain) and the ULB (Universite Libre de Bruxelles, Belgium). Also, I hold an MSc in Biostatistics from the University of Newcastle, Australia, an MSc in Epidemiology from the ULB and an MPH from the UGR. After the completion of my Ph.D. in 2010, I moved to the Center for Infectious Disease Epidemiology and Research (University of Cape Town) as a postdoctoral fellow for two years. Afterward, I moved to the Harvard School of Public Health (Department of Epidemiology), where I specialized in epidemiologic methods from 2012 to 2015. I have also been trained as an Epidemic Intelligence Officer (EIS), and I worked as a field epidemiologist for several years in different African countries with Médecins Sans Frontières and GOARN-WHO during the Cholera epidemic in Haiti, 2010. In Europe, I worked as an epidemiologist for the local government of the city of Brussels identifying socio-demographic and economic determinants of health inequalities. 

Affiliations

Faculty of Epidemiology and Population Health
Department of Non-communicable Disease Epidemiology

Centres

Centre for Evaluation
Centre for Statistical Methodology

Teaching

I teach on various modules of the distance learning MSc in Epidemiology, such as the Advanced Statistical Methods in Epidemiology (EPM304), and Causal Inference for the MSc in Medical Statistics. I have been co-organized of the module EPM307 (Global Epidemiology of Non-Communicable Diseases). Also, I have taught "Introduction to Survival Analysis" on the annual short course “Cancer Survival: Principles, Methods and Applications” organized by the Cancer Survival Group.

Research

My research interests lie principally, but not exclusively in the field of epidemiologic methods aiming to assess the determinants of social inequalities in population health outcomes and comparative effectiveness research with a specific interest in longitudinal analysis, causal inference, repeated measures, and translational epidemiology. At UCT, I used marginal structural models applied to large longitudinal data from Khayelitsha (HIV-Cohort) to assess the effectiveness of an observational, nonrandomized intervention. At Harvard, I used fixed effects methods in the context of the analysis of the components of the variance and within siblings design (observational cross-over) to evaluate the effect of a small fetoplacental ratio at birth on the risk of delivering a small for gestational age infant. Recently, using multilevel analysis, I studied the contextual effect of regional unemployment on stillbirth by geographical regions in Spain as a complement to previous studies where I evaluated the multiplicative effect of maternal education and ethnicity on the risk of delivering a stillborn.

Currently, I am studying the impact of the 2009 economic crisis on stillbirth rates among African immigrant women in Spain and evaluating the best framework to extract cancer patients comorbidity information from population-based administrative records. Also, I am developing in collaboration with colleagues from the Cancer Survival Group data-adaptive methods for model selection and evaluation based on cross-validation techniques (cvAUROC) and applying advanced causal inference methods such as targeted maximum likelihood estimation (TMLE) to study cancer outcomes.

Recently, I have programmed the implementation of TMLE for Stata statistical software users, named ELTMLE and divulgated it at the Stata Users Group Meeting in London, 2017 and Barcelona 2018. Together with collaborators from the ICON Group, we proposed a structural framework for population-based cancer epidemiology and evaluate the performance of double-robust estimators for a binary exposure in cancer mortality. In simulations studies, we have demonstrated that TMLE shows the best bias-variance trade-off, more precise estimates, and appropriate 95% confidence interval coverage than its competitors, supporting the use of the data-adaptive model selection strategies based on machine-learning algorithms. We applied TMLE to estimate adjusted one-year mortality risk differences in 183,426 lung cancer patients diagnosed after admittance to an emergency department versus non-emergency cancer diagnosis in England, 2006–2013. The adjusted mortality risk (for patients diagnosed with lung cancer after admittance to an emergency department) was 16% higher in men and 18% higher in women, suggesting the importance of interventions targeting early detection of lung cancer signs and symptoms.

Research Area
Clinical databases
Diagnostics
Health inequalities
Maternal health
Perinatal health
Public health
Statistical methods
Water
Global Health
Impact evaluation
Inequalities
Methodology
Migration
Outbreaks
Reproductive health
Discipline
Anthropology
Epidemiology
Statistics
Disease and Health Conditions
Cancer
Cardiovascular disease
Chronic disease
HIV/AIDS
Malaria
Malnutrition
Measles
Sexually transmitted disease
Non-communicable diseases
Obesity
Sexually transmitted infection
Country
Central African Republic
Democratic Republic of the Congo
Spain
United Kingdom
Haiti
Iceland
Peru
Chad
United States of America
South Africa
Zambia
Zimbabwe
Region
European Union
Latin America & Caribbean (all income levels)
North America
South Asia
Sub-Saharan Africa (all income levels)

Selected Publications

Doxorubicin and subsequent risk of cardiovascular diseases among survivors of diffuse large B-cell lymphoma in Hong Kong.
Lee SF; Luque-Fernandez MA; Chen YH; Catalano PJ; Chiang CL; Wan EY-F; Wong IC-K; Chen MH; Ng AK
2020
Blood advances
Multimorbidity and short-term overall mortality among colorectal cancer patients in Spain: A population-based cohort study.
Luque-Fernandez MA; Gonçalves K; Salamanca-Fernández E; Redondo-Sanchez D; Lee SF; Rodríguez-Barranco M; Carmona-García MC; Marcos-Gragera R; Sánchez M-J
2020
European journal of cancer (Oxford, England : 1990)
Multimorbidity by Patient and Tumor Factors and Time-to-Surgery Among Colorectal Cancer Patients in Spain: A Population-Based Study.
Luque-Fernandez MA; Redondo-Sanchez D; Lee SF; Rodríguez-Barranco M; Carmona-García MC; Marcos-Gragera R; Sánchez M-J
2020
Clinical epidemiology
Socioeconomic Inequalities in Colorectal Cancer Survival in Southern Spain: A Multilevel Population-Based Cohort Study.
Luque-Fernandez MA; Redondo-Sánchez D; Rodríguez-Barranco M; Chang-Chan Y-L; Salamanca-Fernández E; Núñez O; Fernandez-Navarro P; Pollán M; Sánchez M-J
2020
Clinical epidemiology
CVAUROC: Stata module to compute Cross-validated Area Under the Curve for ROC Analysis after Predictive Modelling for Binary Outcomes
Luque-Fernandez MA; Maringe C; Nelson P
2019
Effect Modification and Collapsibility in Evaluations of Public Health Interventions.
Luque-Fernandez MA; Redondo-Sanchez D; Schomaker M
2019
American journal of public health
Using longitudinal targeted maximum likelihood estimation in complex settings with dynamic interventions.
Schomaker M; Luque-Fernandez MA; Leroy V; Davies MA
2019
arXiv preprint arXiv:180205005
Targeted maximum likelihood estimation for a binary treatment: A tutorial.
Luque-Fernandez MA; Schomaker M; Rachet B; Schnitzer ME
2018
Statistics in medicine
Educational Note: Paradoxical collider effect in the analysis of non-communicable disease epidemiological data: a reproducible illustration and web application.
Luque-Fernandez MA; Schomaker M; Redondo-Sanchez D; Jose Sanchez Perez M; Vaidya A; Schnitzer ME
2018
arXiv preprint arXiv:180907111
Using Longitudinal Targeted Maximum Likelihood Estimation in Complex Settings with Dynamic Interventions
Schomaker M; Luque-Fernandez MA; Leroy V; Davies M-A
2018
arXiv preprint arXiv:1802.05005
ELTMLE: Stata module to provide Ensemble Learning Targeted Maximum Likelihood Estimation
Luque-Fernandez MA
2017
\"Nonfunctional\" Adrenal Tumors and the Risk for Incident Diabetes and Cardiovascular Outcomes: A Cohort Study.
Lopez D; Luque-Fernandez MA; Steele A; Adler GK; Turchin A; Vaidya A
2016
Annals of internal medicine
Adjusting for overdispersion in piecewise exponential regression models to estimate excess mortality rate in population-based research.
Luque-Fernandez MA; Belot A; Quaresma M; Maringe C; Coleman MP; Rachet B
2016
BMC medical research methodology
Deconstructing the smoking-preeclampsia paradox through a counterfactual framework.
Luque-Fernandez MA; Zoega H; Valdimarsdottir U; Williams MA
2016
European journal of epidemiology
Is the fetoplacental ratio a differential marker of fetal growth restriction in small for gestational age infants?
Luque-Fernandez MA; Ananth CV; Jaddoe VWV; Gaillard R; Albert PS; Schomaker M; McElduff P; Enquobahrie DA; Gelaye B; Williams MA
2015
European journal of epidemiology
Unemployment and stillbirth risk among foreign-born and Spanish pregnant women in Spain, 2007-2010: a multilevel analysis study.
Luque-Fernandez MA; Franco M; Gelaye B; Schomaker M; Garitano IG; D'Este C; Williams MA
2013
European journal of epidemiology
Seasonal Variation of 25-Hydroxyvitamin D among non-Hispanic Black and White Pregnant Women from Three US Pregnancy Cohorts
Luque-Fernandez MA; Gelaye B; VanderWeele T; Ferre C; Siega-Riz AM; Holzman C; Enquobahrie D; Dole N; Williams MA
2013
Pediatrics and Perinatal Epidemiology
Seasonal variation of 25-hydroxyvitamin D among non-Hispanic black and white pregnant women from three US pregnancy cohorts.
Luque-Fernandez MA; Gelaye B; VanderWeele T; Ferre C; Siega-Riz AM; Holzman C; Enquobahrie DA; Dole N; Williams MA
2013
Paediatric and perinatal epidemiology
Effectiveness of patient adherence groups as a model of care for stable patients on antiretroviral therapy in Khayelitsha, Cape Town, South Africa.
Luque-Fernandez MA; Van Cutsem G; Goemaere E; Hilderbrand K; Schomaker M; Mantangana N; Mathee S; Dubula V; Ford N; Hernán MA
2013
PloS one
Elevation and cholera: an epidemiological spatial analysis of the cholera epidemic in Harare, Zimbabwe, 2008-2009.
Luque Fernandez MA; Schomaker M; Mason PR; Fesselet JF; Baudot Y; Boulle A; Maes P
2012
BMC public health
Stillbirth risk by maternal socio-economic status and country of origin: a population-based observational study in Spain, 2007-08.
Luque-Fernández MÁ; Lone NI; Gutiérrez-Garitano I; Bueno-Cavanillas A
2011
European journal of public health
Accuracy of MUAC in the detection of severe wasting with the new WHO growth standards.
Fernández MAL; Delchevalerie P; Van Herp M
2010
Pediatrics
Descriptive spatial analysis of the cholera epidemic 2008-2009 in Harare, Zimbabwe: a secondary data analysis.
Luque Fernández MÁ; Mason PR; Gray H; Bauernfeind A; Fesselet JF; Maes P
2010
Transactions of the Royal Society of Tropical Medicine and Hygiene
Influence of temperature and rainfall on the evolution of cholera epidemics in Lusaka, Zambia, 2003-2006: analysis of a time series.
Luque Fernández MA; Bauernfeind A; Jiménez JD; Gil CL; El Omeiri N; Guibert DH
2008
Transactions of the Royal Society of Tropical Medicine and Hygiene
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