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Dr Palwasha Khan

Clinical Associate Professor

London School of Hygiene & Tropical Medicine
United Kingdom

I undertook my specialist clinical training in Sexual Health and HIV medicine in London and currently hold an honorary consultant contract in HIV medicine in Cardiff. During my clinical training, I was fortunate to be awarded an MRC studentship to study the MSc Epidemiology at LSHTM and went on to undertake a Clinical PhD based overseas, funded by the Wellcome Trust on investigating M. tuberculosis transmission in rural Malawi using infection status (inferred from tuberculin skin test positivity) in young children as sentinels of recent transmission.

My clinical training has provided me with biological and clinical insights into a wide variety of infectious diseases and my MSc and PhD training in infectious disease epidemiology has provided me with an in-depth understanding of population-level transmission dynamics and host-pathogen interactions within society. I have subsequently developed considerable expertise in the field of M. tuberculosis transmission as a field epidemiologist. With my specialisation in Sexual Health and HIV medicine and current clinical practice and research training, I have a deep appreciation of the importance of context and how that impacts the individual and population-level outcomes of infectious diseases.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

TB Centre

Teaching

I am one of the module organisers for the in-house Epidemiology of Infectious Diseases and have taught on a wide variety of courses in the in-house and distance learning MSc Epidemiology, MSc Infectious Diseases, MSc Clinical Trials and East Africa DTM&H.

Research

My research focus is on furthering our understanding of M.tuberculosis transmission in different epidemiological contexts and characterising the role of socio-biological mechanisms that are driving disparities in exposure and susceptibility to M. tuberculosis which leads to the differential distribution of tuberculosis observed in populations. I also work with the endTB consortium (https://endtb.org/) to improve the programmatic management of drug-resistant tuberculosis in resource-limited setting through generating a robust evidence base to guide management. I am passionate about using the best available most up-to-date statistical methods to answer the research question

I would like to gain further expertise in the use of advanced formal causal inference methods as part of my research. Novel statistical methods are continuously being developed in the quantitative sciences (ecology, social science, econometrics, cognitive sciences etc.) which allow us to potentially use and combine available multi-level data in models to better describe and understand drivers of M.tuberculosis transmission within societies. These models can then be used to inform the design of new interventions and/or bespoke combination of interventions for a given setting. Targeting TB care and prevention strategies specific to the local epidemiological and societal context are much more likely to be effective than the ‘one size fits all’ approach that has been adopted to date.

Research Area
Clinical databases
Drug resistance
Electronic health records
Global Health
Impact evaluation
International comparisons
Methodology
Outbreaks
Public health
Statistical methods
Surveillance
Epidemiology
GIS/Spatial analysis
Immunoepidemiology
Implementation science
Capacity development
Disease and Health Conditions
HIV/AIDS
Tuberculosis
Infectious diseases
Sexually transmitted infections
Country
Malawi
Pakistan
South Africa
Region
South Asia
Sub-Saharan Africa (all income levels)

Selected Publications

Culture Conversion in Patients Treated with Bedaquiline and/or Delamanid. A Prospective Multicountry Study.
Franke, MF; KHAN, P; Hewison, C; Khan, U; Huerga, H; Seung, KJ; Rich, ML; Zarli, K; Samieva, N; Oyewusi, L; Nair, P; Mudassar, M; Melikyan, N; Lenggogeni, P; Lecca, L; Kumsa, A; Khan, M; Islam, S; Hussein, K; Docteur, W; Chumburidze, N; Berikova, E; Atshemyan, H; Atwood, S; Alam, M; ... Mitnick, CD.
2021
American Journal of Respiratory and Critical Care Medicine
Concurrent adult pulmonary tuberculosis prevalence survey using digital radiography and Xpert MTB/RIF Ultra and child interferon-gamma release assay Mycobacterium tuberculosis infection survey in Karachi, Pakistan: a study protocol.
KHAN, PY; Paracha, MS; GRUNDY, C; Saeed, S; Dojki, M; Madhani, F; Page-Shipp, L; Khursheed, N; Rabbani, W; Riaz, N; Khowaja, S; Hussain, O; Habib, A; Khan, U; KRANZER, K; FERRAND, RA; Lewis, JJ; Khan, AJ; FIELDING, KL;
2020
Wellcome Open Research
Automated chest radiography and mass systematic screening for tuberculosis.
Madhani, F; Maniar, RA; Burfat, A; Ahmed, M; Farooq, S; Sabir, A; Domki, AK; Page-Shipp, L; Khowaja, S; Safdar, N; Khan, AJ; KHAN, PY;
2020
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Investigation of an extensive outbreak of HIV infection among children in Sindh, Pakistan: protocol for a matched case-control study.
Siddiqui, AR; Ali Nathwani, A; Abidi, SH; Mahmood, SF; Azam, I; Sawani, S; Kazi, AM; Hotwani, A; Memon, SA; Soomro, J; Shaikh, SA; Achakzai, B; Saeed, Q; SIMMS, V; KHAN, P; FERRAND, R; Mir, F;
2020
BMJ Open
HIV infection predominantly affecting children in Sindh, Pakistan, 2019: a cross-sectional study of an outbreak.
Mir, F; Mahmood, F; Siddiqui, AR; Baqi, S; Abidi, SH; Kazi, AM; Nathwani, AA; Ladhani, A; Qamar, FN; Soofi, SB; Memon, SA; Soomro, J; Shaikh, SA; SIMMS, V; KHAN, P; FERRAND, RA;
2019
Lancet Infectious Diseases
Paediatric tuberculosis transmission outside the household: challenging historical paradigms to inform future public health strategies.
Martinez, L; Lo, NC; Cords, O; Hill, PC; KHAN, P; Hatherill, M; Mandalakas, A; Kay, A; Croda, J; Horsburgh, CR; Zar, HJ; Andrews, JR;
2019
LANCET RESPIRATORY MEDICINE
Transmission of drug-resistant tuberculosis in HIV-endemic settings.
KHAN, PY; Yates, TA; Osman, M; Warren, RM; Van der Heijden, Y; Padayatchi, N; Nardell, EA; MOORE, D; Mathema, B; Gandhi, N; Eldholm, V; DHEDA, K; Hesseling, AC; Mizrahi, V; Rustomjee, R; Pym, A;
2018
LANCET INFECTIOUS DISEASES
Risk of Mycobacterium tuberculosis transmission in an antiretroviral therapy clinic.
MZEMBE, T; MCLEAN, E; KHAN, PY; KOOLE, O; Sichali, L; Mwinuka, V; Kayange, M; Mzumara, P; Dimba, A; CRAMPIN, AC; GLYNN, JR;
2018
AIDS (London, England)
Does antiretroviral treatment increase the infectiousness of smear-positive pulmonary tuberculosis?
KHAN, PY; CRAMPIN, AC; MZEMBE, T; KOOLE, O; FIELDING, KL; KRANZER, K; GLYNN, JR;
2017
The international journal of tuberculosis and lung disease
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