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Dr Palwasha Khan

MBBCh MRCS MRCP DTM&H MSc DipGUM DFSRH DipHIV PhD

Associate Professor
Infectious Disease Epidemiology

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I undertook my specialist clinical training in Sexual Health and HIV medicine in London and currently hold an honorary consultant contract in HIV medicine in Cardiff. During my clinical training, I was fortunate to be awarded an MRC studentship to study the MSc Epidemiology at LSHTM and went on to undertake a Clinical PhD based overseas, funded by the Wellcome Trust on investigating M.tuberculosis transmission in rural Malawi using infection status (inferred from tuberculin skin test positivity) in young children as sentinels of recent transmission.

Since completing my specialist clinical and research training, I work part-time with LSHTM as a Clinical Associate Professor where I lead an NIH-funded study exploring the infectiousness of different types of TB patients (HIV positive on ART versus HIV positive not on ART; asymptomatic versus symptomatic) at the Africa Health Research Institute, KwaZulu Natal, South Africa. My aim is also to set up a TB surveillance system within the AHRI demographic surveillance area, whilst strengthening local Department of Health data capacity.

I also work part-time for Interactive Research and Development (IRD) as a clinical epidemiologist. I was based out in Karachi during 2018-2019 to undertake a TB prevalence survey using CAD4TB and Ultra where we screened more than 30,000 adults to estimate the burden of infectious tuberculosis in the city. This forms the initial part of an impact evaluation of the Zero TB Cities project implemented in Karachi  since 2018 with a planned endline survey some time in 2022-2023. I also work on the endTB project with IRD as part of a consoritum with Médécins Sans Frontières and Partners in Health (http://endtb.org), which aims to find shorter, less toxic and more effective treatments for multidrug resistant tuberculosis.

Despite the challenges, I enjoy working at the clinical academia-implementation interface, especially in low- and middle-income countries. It helps to reduce the disconnect that can occur with purely academic research and maintain a healthy level of pragmatism whilst striving to improve health for all.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases
Faculty of Epidemiology and Population Health
Department of Infectious Disease Epidemiology

Centres

Centre for Evaluation
Centre for Statistical Methodology
TB Centre

Teaching

I have taught on a wide variety of courses in the In-house and Distance Learning MSc Epidemiology, MSc Infectious Diseases, MSc Clinical Trials and East Africa DTM&H.

I also teach on the In-house teaching on Intensive Course on Epidemiology and Medical Statistics short course.

Research

My research focus is on furthering our understanding of M.tuberculosis transmission in different epidemiological contexts and improving the programmatic management of drug-resistant tuberculosis in resource-limited setting through generating the evidence base to guide management. I would like to gain more experience in the use of advanced formal causal inference methods as part of my research.

Research Area
Statistical methods
Surveillance
Global Health
Implementation research
Spatial analysis
Discipline
Molecular epidemiology
Epidemiology
GIS/Spatial analysis
Medicine
Operational research
Disease and Health Conditions
HIV/AIDS
Infectious disease
Tuberculosis
Sexually transmitted infection
Country
Malawi
Pakistan
South Africa
Region
South Asia
Sub-Saharan Africa (all income levels)

Selected Publications

Culture Conversion in Patients Treated with Bedaquiline and/or Delamanid: A Prospective Multi-country Study
Franke MF; Khan P; Hewison C; Khan U; Huerga H; Seung KJ; Rich ML; Zarli K; Samieva N; Oyewusi L
2020
American Journal of Respiratory and Critical Care Medicine
Automated chest radiography and mass systematic screening for tuberculosis.
Madhani F; Maniar RA; Burfat A; Ahmed M; Farooq S; Sabir A; Domki AK; Page-Shipp L; Khowaja S; Safdar N
2020
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Investigation of an extensive outbreak of HIV infection among children in Sindh, Pakistan: protocol for a matched case-control study.
Siddiqui AR; Ali Nathwani A; Abidi SH; Mahmood SF; Azam I; Sawani S; Kazi AM; Hotwani A; Memon SA; Soomro J
2020
BMJ Open
Paediatric tuberculosis transmission outside the household: challenging historical paradigms to inform future public health strategies.
Martinez L; Lo NC; Cords O; Hill PC; Khan P; Hatherill M; Mandalakas A; Kay A; Croda J; Horsburgh CR
2019
LANCET RESPIRATORY MEDICINE
HIV infection predominantly affecting children in Sindh, Pakistan, 2019: a cross-sectional study of an outbreak.
Mir F; Mahmood F; Siddiqui AR; Baqi S; Abidi SH; Kazi AM; Nathwani AA; Ladhani A; Qamar FN; Soofi SB
2019
Lancet Infectious Diseases
Transmission of drug-resistant tuberculosis in HIV-endemic settings.
Khan PY; Yates TA; Osman M; Warren RM; van der Heijden Y; Padayatchi N; Nardell EA; Moore D; Mathema B; Gandhi N
2018
LANCET INFECTIOUS DISEASES
Risk of Mycobacterium tuberculosis transmission in an antiretroviral therapy clinic.
Mzembe T; Mclean E; Khan PY; Koole O; Sichali L; Mwinuka V; Kayange M; Mzumara P; Dimba A; Crampin AC
2018
AIDS (London, England)
Does antiretroviral treatment increase the infectiousness of smear-positive pulmonary tuberculosis?
Khan PY; Crampin AC; Mzembe T; Koole O; Fielding KL; Kranzer K; Glynn JR
2017
The international journal of tuberculosis and lung disease
Challenges in the Estimation of the Annual Risk of Mycobacterium tuberculosis Infection in Children Aged Less Than 5 Years.
Khan PY; Glynn JR; Mzembe T; Mulawa D; Chiumya R; Crampin AC; Kranzer K; Fielding KL
2017
American journal of epidemiology
Mycobacterium tuberculosis transmission from patients with drug-resistant compared to drug-susceptible TB: a systematic review and meta-analysis.
Kodama C; Lange B; Olaru ID; Khan P; Lipman M; Seddon JA; Sloan D; Grandjean L; Ferrand RA; Kranzer K
2017
The European respiratory journal
Diagnostic accuracy of the Xpert® MTB/RIF cycle threshold level to predict smear positivity: a meta-analysis.
Lange B; Khan P; Kalmambetova G; Al-Darraji HA; Alland D; Antonenka U; Brown T; Balcells ME; Blakemore R; Denkinger CM
2017
The international journal of tuberculosis and lung disease
Risk factors for Mycobacterium tuberculosis infection in 2-4 year olds in a rural HIV-prevalent setting.
Khan PY; Glynn JR; Fielding KL; Mzembe T; Mulawa D; Chiumya R; Fine PEM; Koole O; Kranzer K; Crampin AC
2016
The international journal of tuberculosis and lung disease
The transmission of Mycobacterium tuberculosis in high burden settings.
Yates TA; Khan PY; Knight GM; Taylor JG; McHugh TD; Lipman M; White RG; Cohen T; Cobelens FG; Wood R
2016
The Lancet infectious diseases
The effect of HIV and antiretroviral therapy on characteristics of pulmonary tuberculosis in northern Malawi: a cross-sectional study.
Munthali L; Khan PY; Mwaungulu NJ; Chilongo F; Floyd S; Kayange M; Glynn JR; French N; Crampin AC
2014
BMC infectious diseases
See more Publications