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Dr Shiromani Jayawardhana

Research Fellow

United Kingdom

Jump to: Affiliations Publications

Affiliations
Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Selected Publications
Beyond translation: How amino acid metabolism shapes Trypanosoma cruzi’s life cycle and virulence.
Janaina, DF N; Marilene, DS B; Fortes Francisco, A; JAYAWARDHANA, S; Araujo Mengarda, AC; Santos Souza, HF; Ballari, S; Bezerra Alencar, VJ; Agripino, JD M; Correa Garcia, M; Rodriguez Duran, JJ; Genta, FA; TAYLOR, M; Kelly, J; Silber, AM;
2025
Reuniao da Sociedade Brasileira de Protozoologia - Caxambu
A Rapid Method for Purifying Intact Trypanosoma cruzi Amastigotes from Host Cells, In Vitro and In Vivo, for Downstream 'Omic Analysis.
Olmo, F; JAYAWARDHANA, S; ATHERTON, RL; KELLY, JM;
2025
Methods in molecular biology (Clifton, N.J.)
Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease.
JAYAWARDHANA, S; Olmo, F; FORTES FRANCISCO, A; Khan, AA; LEWIS, MD; TAYLOR, MC; KELLY, JM;
2025
Antimicrobial agents and chemotherapy
Statins do not reduce the parasite burden during experimental Trypanosoma cruzi infection.
Razzaq, S; Olmo, F; Lakshminarayana, SB; Ying-Bo, C; JAYAWARDHANA, S; Rao, SP S; KELLY, JM; A F, F;
2025
Antimicrobial agents and chemotherapy
Animal models for exploring Chagas disease pathogenesis and supporting drug discovery.
Khan, AA; TAYLOR, MC; FORTES FRANCISCO, A; JAYAWARDHANA, S; ATHERTON, RL; Olmo, F; LEWIS, MD; KELLY, JM;
2024
Clinical microbiology reviews
Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice.
JAYAWARDHANA, S; Ward, AI; FRANCISCO, AF; LEWIS, MD; TAYLOR, MC; KELLY, JM; Olmo, F;
2023
PLoS Pathogens
Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitological cure.
FRANCISCO, AF; Saade, U; JAYAWARDHANA, S; Pottel, H; Scandale, I; Chatelain, E; Liehl, P; KELLY, JM; Zrein, M;
2022
PLoS neglected tropical diseases
Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity.
TAYLOR, MC; Ward, AI; Olmo, F; FRANCISCO, AF; JAYAWARDHANA, S; Costa, FC; LEWIS, MD; KELLY, JM;
2020
Current pharmaceutical design
In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution.
Ward, AI; LEWIS, MD; KHAN, AA; McCann, CJ; FRANCISCO, AF; JAYAWARDHANA, S; TAYLOR, MC; KELLY, JM;
2020
mBio
Challenges in Chagas Disease Drug Development.
FRANCISCO, AF; JAYAWARDHANA, S; Olmo, F; LEWIS, MD; Wilkinson, SR; TAYLOR, MC; KELLY, JM;
2020
MOLECULES
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Contact

United Kingdom