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Dr Dea Hazewinkel

Research Fellow

United Kingdom

I am a medical statistician and a research fellow in the Department of Medical Statistics at the LSHTM, since April 2023. In addition to my research, I also act as an early career researcher reprentative (ECR rep), admissions tutor for the Medical Statistics MSc, and member of the Research Staff Forum (for the Concordat monitoring group), and additionally co-organise the IRM monthly meetings, at which members of the MedStats department present recent and ongoing research. Prior to my appointment at LSHTM, I held a short-term fellowship at the University of Bristol. There, at the MRC Integrative Epidemiology Unit, is also where I completed my PhD (2022), on the subject of identifying and adjusting for bias resulting from missing outcomes in clinical trials. I completed my 2-year research MSc in Statistics for the Life and Behavioural Sciences in 2018, at the University of Leiden (The Netherlands), with a focus on Cox-model extensions and machine learning alternatives for survival outcomes, with applications in osteosarcoma. 

 

My current research involves the development and application of methods for recurrent events in a survival framework, with a particular focus on heart failure hospitalisations and cardiovascular disease. Within this, key themes are the use of recurrent-event versus time-to-first event analyses, the impact of the violation of estimator assumptions, and the win ratio method for composite outcomes. Previous areas of research include bias resulting from missing-not-at-random dropout in clinical trials, multi-state and dynamic prediction modelling for time-to-event outcomes in osteosarcoma, and machine-learning methods for survival outcomes (specifically, neural networks and random survival forests). More generally, I am interested in the various biases that may arise from protocol and design deviations in clinical trials and in developing methods with estimator assumptions that are plausible in a clinical setting.

Affiliations

Department of Medical Statistics
Faculty of Epidemiology and Population Health

Teaching

I am a co-module organsier for the Inference submodule of the Foundations module of the Medical Statistics MSc. I additionally teach on several additional modules of the the same MSc (Clinical Trials; Statistical Models for Discrete Outcomes), and aditionally act as a personal student tutor and MSc project supervisor. Recently I completed my Postgraduate Certificate in Learning and Teaching (PGCILT) at the associate fellowship level (AFHEA). 

Research

My current research involves the development and application of methods for recurrent events in a survival framework, with a particular focus on heart failure hospitalisations and cardiovascular disease. Within this, key themes are the use of recurrent-event versus time-to-first event analyses, the impact of the violation of estimator assumptions, and the win ratio method for composite outcomes. Previous areas of research include bias resulting from missing-not-at-random dropout in clinical trials, multi-state and dynamic prediction modelling for time-to-event outcomes in osteosarcoma, and machine-learning methods for survival outcomes (specifically, neural networks and random survival forests). More generally, I am interested in the various biases that may arise from protocol and design deviations in clinical trials and in developing methods with estimator assumptions that are plausible in a clinical setting.

Research Area
Statistical methods
Applied statistics (medical)
Disease and Health Conditions
Cardiovascular diseases
Stroke

Selected Publications

Re-Evaluating Recurrent Events in Heart Failure Trials: Patterns, Prognostic Implications, and Analytical Improvements.
HAZEWINKEL, A-D; GREGSON, J; POCOCK, SJ; McMurray, J; Solomon, SD; Claggett, B; Packer, M; Anker, SD; Ferreira, JP; Docherty, K; Henderson, A; Jhund, P; Wilderäng, U; Wright, D;
2025
Journal of the American College of Cardiology
Scoping review of software implementations of risk-of-bias tools and quantitative bias analysis methods for sample selection bias
HAZEWINKEL, A-D; Curnow, E; Tilling, K; Hughes, RA;
2026
Springer Science and Business Media LLC
Covariate adjustment for hierarchical outcomes and the win ratio: how to do it and is it worthwhile?
HAZEWINKEL, A-D; Gregson, J; Bartlett, JW; Gasparyan, SB; Wright, D; Pocock, S;
2026
openRxiv
Reevaluating Recurrent Events in Heart Failure Trials: Patterns, Prognostic
Implications, and Analytical Improvements
HAZEWINKEL, A-D; GREGSON, J; Pocock, S; McMurray, J; Solomon, SD; Claggett, B; Packer, M; Anker, S; Ferreira, J; Docherty, K; Henderson, A; Jhund, P; Wilderang, U; Wright, D;
2025
International Society for Clinical Biostatistics (ISCB)
Optimised medical therapy alone versus optimised medical therapy plus revascularisation for asymptomatic or low-to-intermediate risk symptomatic carotid stenosis (ECST-2): 2-year interim results of a multicentre randomised trial.
Donners, SJ A; Van Velzen, TJ; Cheng, SF; GREGSON, J; HAZEWINKEL, A-D; Pizzini, FB; Emmer, BJ; Simister, R; Richards, T; Lyrer, PA; Maurer, M; Smith, G; Tervit, G; Van der Steen, L; Pickett, GE; Gubitz, G; Roozenbeek, B; Scheele, M; Bamford, JM; Kooi, ME; De Borst, GJ; Jäger, HR; Brown, MM; Nederkoorn, PJ; Bonati, LH; ... ECST-2 investigators,
2025
The Lancet neurology
Use of the Win Ratio for Analysis of Stroke Trials: Description, Illustration, and Planned Use in the Second European Carotid Surgery Trial (ECST-2).
GREGSON, J; Donners, SJ A; Dippel, D; Lingsma, H; Dea Hazewinkel, A; Brown, MM; Bonati, LH; Nederkoorn, PJ;
2024
Stroke
Time patterns of repeat non-fatal events and death in heart failure trials: implications for improving future research
HAZEWINKEL, A-D; GREGSON, J; Pocock, S;
2024
International Clinical Trials Methodology Conference
Time patterns of repeat non-fatal events and death in heart failure trials: implications for improving future research.
HAZEWINKEL, A-D; Gregson, J; Pocock, S;
2024
International Clinical Trials Methodology Conference
Dynamic Prediction of Overall Survival for Patients with Osteosarcoma: A Retrospective Analysis of the EURAMOS-1 Clinical Trial Data.
Spreafico, M; HAZEWINKEL, A-D; Gelderblom, H; Fiocco, M;
2024
Current oncology (Toronto, Ont.)
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