Professor Richard Grieve


of Health Economics Methodology

Room 144

15-17 Tavistock Place
United Kingdom

020 7927 2255

I lead a research team whose current research focuses on developing quantitative methods for the evaluation of health care programmes. Our expertise is in the design and analysis of observational studies as well as RCTs, and in methods for cost-effectiveness analyses. We are developing methods that address common methodological issues such as confounding due to treatment selection; non-compliance, missing data,  and external validity.

We undertake applied health economic evaluations predominately in the areas of adult and paediatric intensive care, emergency medicine, emergency and elective surgery, and to the evaluation of new health policies.

My current research interests are focused around methods for using large-scale observational data to provide estimates of effectiveness and cost-effectiveness that can relate directly to individual patients. This research programme includes NIHR funded studies evaluating emergency surgery and treatment intensification for patients with type 2 Diabetes Mellitus.

I am the co-director of the LSHTM centre for statistical methodology and sit on the NIHR commissioning board.


Department of Health Services Research and Policy


Centre for Statistical Methodology


I teach on the introductory module, introduction to health economics, and organise the economic evaluation module


My main research interests are in developing analytical methods for cost-effectiveness analyses, in particular those that use non-randomised study designs. My current work aims to develop more appropriate analytical methods for dealing with confounding due to treatment selection, missing data and issues raised by moves towards personalised medicine.

I have received methodological grants from the ESRC on methods for reducing selection bias in health economic evaluation, and from the MRC for developing analytical methods for economic evaluations that use data from cluster randomised trials.

I have ongoing interests in applying the techniques of economic evaluation across a diverse range of clinical areas including adult and paediatric intensive care, hepatitis C, mental health, and for emergency and elective surgical procedures. 

I am interested in supervising PhD students in the general area of statistical methods and health economic evaluation.

Research Area
Economic evaluation
Health policy
Health technology assessment
Statistical methods
Disease and Health Conditions
Cardiovascular disease

Selected Publications

Estimating treatment effects under untestable assumptions with nonignorable missing data.
Gomes M; Kenward MG; Grieve R; Carpenter J
Statistics in medicine
Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial.
Lamontagne F; Richards-Belle A; Thomas K; Harrison DA; Sadique MZ; Grieve RD; Camsooksai J; Darnell R; Gordon AC; Henry D
A comparison of methods for health policy evaluation with controlled pre-post designs.
O'Neill S; Kreif N; Sutton M; Grieve R
Health services research
OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients.
The OpenSAFELY Collaborative; Williamson E; Walker A; Bhaskaran K; Bacon S; Bates C; Morton C; Curtis H; Mehrkar A; Evans D
A framework for extending trial design to facilitate missing data sensitivity analyses.
Mason AJ; Grieve RD; Richards-Belle A; Mouncey PR; Harrison DA; Carpenter JR
BMC medical research methodology
Predicting risk of cardiovascular events 1 to 3 years post-myocardial infarction using a global registry.
Pocock SJ; Brieger D; Gregson J; Chen JY; Cohen MG; Goodman SG; Granger CB; Grieve R; Nicolau JC; Simon T
Clinical cardiology
Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial
Richards-Belle A; Mouncey PR; Grieve RD; Harrison DA; Sadique MZ; Henry D; Whitman C; Camsooksai J; Gordon AC; Young JD
Journal of the Intensive Care Society
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