Professor Richard Grieve


of Health Economics Methodology

Room 144

15-17 Tavistock Place
United Kingdom

020 7927 2255

I lead a research team whose current research focuses on developing quantitative methods for the evaluation of health care programmes. Our expertise is in the design and analysis of observational studies as well as RCTs, and in methods for cost-effectiveness analyses. We are developing methods that address common methodological issues such as confounding due to treatment selection; non-compliance, missing data,  and external validity.

We also undertake applied health economic evaluations predominately in the areas of adult and paediatric intensive care, emergency medicine, emergency and elective surgery, and to the evaluation of new health policies. We have recently started an evaluation of the integrated care pioneers, and have undertaken research evaluating the preferences of blood donors for alternative changes to the blood collection service.


My research programme is funded by a five year senior research fellowship from NIHR.

I am the co-director of the LSHTM centre for statistical methodology and sit on the NIHR commissioning board.


Department of Health Services Research and Policy


Statistical Methodology


I teach on the introductory module, introduction to health economics, and organise the economic evaluation module


My main research interests are in developing analytical methods for cost-effectiveness analyses, in particular those that use non-randomised study designs. My current work aims to develop more appropriate analytical methods for dealing with confounding due to treatment selection, missing data and clustered data.

I have received methodological grants from the ESRC on methods for reducing selection bias in health economic evaluation. I was also the PI on a year MRC funded project to investigate analytical methods for economic evaluations that use data from cluster randomised trials.

I have ongoing interests in applying the techniques of economic evaluation across a diverse range of clinical areas including adult and paediatric intensive care, hepatitis C, mental health, and for emergency and elective surgical procedures. 

I am interested in supervising PhD students in the general area of statistical methods and health economic evaluation.

Research Area
Economic evaluation
Health policy
Health technology assessment
Statistical methods
Disease and Health Conditions
Cardiovascular disease

Selected Publications

Cost-effectiveness of alternative changes to a national blood collection service.
Willis, S. ; De Corte, K. ; Cairns, J.A. ; Zia Sadique, M. ; Hawkins, N. ; Pennington, M. ; Cho, G. ; Roberts, D.J. ; Miflin, G. ; Grieve, R. ;
Transfus Med
Comparative clinical effectiveness and cost effectiveness of endovascular strategy v open repair for ruptured abdominal aortic aneurysm: three year results of the IMPROVE randomised trial
Powell, J.T.; Braithwaite, B.; Cheshire, N.J.; Greenhalgh, R.M.; Grieve, R.D.; Hassan, T.B.; Hinchliffe, R.J.; Howell, S.; Moore, F.; Nicholson, A.A.; Thompson, M.M.; Thompson, S.G.; Investigators, I.T.
Bmj-British Medical Journal
Methods for estimating complier average causal effects for cost-effectiveness analysis
Diazordaz, K.; Franchini, A.J.; Grieve, R.
Journal of the Royal Statistical Society: Series A (Statistics in Society)
Examination of the Synthetic Control Method for Evaluating Health Policies with Multiple Treated Units.
Kreif, N. ; Grieve, R. ; Hangartner, D. ; Turner, A.J. ; Nikolova, S. ; Sutton, M. ;
Health Econ
Estimating causal effects: considering three alternatives to difference-in-differences estimation.
O'Neill, S.; Kreif, N.; Grieve, R.; Sutton, M.; Sekhon, J.S.;
Health Serv Outcomes Res Methodol
Cancer Drugs Fund requires further reform.
Grieve, R. ; Abrams, K. ; Claxton, K. ; Goldacre, B. ; James, N. ; Nicholl, J. ; Parmar, M. ; Parker, C. ; Sekhon, J.S. ; Smeeth, L. ; Spiegelhalter, D. ; Sculpher, M. ;
From sample average treatment effect to population average treatment effect on the treated: combining experimental with observational studies to estimate population treatment effects
Hartman, E.; Grieve, R.; Ramsahai, R.; Sekhon, J.S.
Journal of the Royal Statistical Society: Series A (Statistics in Society)
See all Professor Richard Grieve's Publications