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Dr Rachael Burke

Clinical Assistant Professor in Training

United Kingdom

I am an Infectious Disease and General (Internal) Medicine registrar. I completed a post as a Wellcome Trust Clinical PhD fellow based in Malawi with the Malawi Liverpool Wellcome Clinical Research Programme in 2023. My research interests are in tuberculosis and HIV co-infection, improving infectious disease diagnostics and in reducing in-hospital mortality for people living with HIV in low income settings. I am currently a distance learning tutor on the MSc in Infectious Diseases, and am delighted to be returning to the school as an NIHR Clinical Lecturer in 2024.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I am a tutor on the LSHTM Distance Learning MSc in Infectious Diseases, contributing to the TB module.

Research

I am conducting a clinical trial of Computer Aided Screening for Tuberculosis in Low Resource Environments (the CASTLE study). This will evaluate the utility of chest x-ray with computer aided diagnosis (CAD) for improving tuberculosis diagnosis among people living with HIV at the point of admission to hospital in Malawi. The trial will also provide information on the prevalance of HIV treatment failure, tuberculosis and other infectious diseases among inpatients at a district general hospital in Malawi.

I am delighted to work with my supervisors Prof Liz Corbett, Dr Peter MacPherson and Dr Ankur Gupta-Wright, as well as advisors and collaborators from College of Medicine Malawi, Liverpool School of Tropical Medicine and LSHTM.

More information about our Malawi Liverpool Wellcome Public Health research group can be found at https://petermacp.github.io/mlw.public.health.group/.

Selected Publications

Reasons for disengagement from antiretroviral care in the era of "Treat All" in low- or middle-income countries: a systematic review.
BURKE, RM; Rickman, HM; Pinto, C; Ehrenkranz, P; Choko, A; Ford, N;
2024
Journal of the International AIDS Society
Same-day versus rapid ART initiation in HIV-positive individuals presenting with symptoms of tuberculosis: Protocol for an open-label randomized non-inferiority trial in Lesotho and Malawi.
Gerber, F; Semphere, R; Lukau, B; Mahlatsi, P; Mtenga, T; Lee, T; Kohler, M; Glass, TR; Amstutz, A; Molatelle, M; MacPherson, P; Marake, NB; Nliwasa, M; Ayakaka, I; BURKE, R; Labhardt, N;
2024
PloS one
Community-level variation in TB testing history in Blantyre, Malawi.
NIGHTINGALE, ES; Feasey, HR A; Khundi, M; Soko, RN; BURKE, RM; Nliwasa, M; Twabi, H; Mpunga, JA; FIELDING, K; MacPherson, P; CORBETT, EL;
2024
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Prevalence of bacteriologically-confirmed pulmonary tuberculosis in urban Blantyre, Malawi 2019-20: Substantial decline compared to 2013-14 national survey.
Feasey, HR A; Khundi, M; Nzawa Soko, R; NIGHTINGALE, E; BURKE, RM; Henrion, MY R; Phiri, MD; BURCHETT, HE; Chiume, L; Nliwasa, M; Twabi, HH; Mpunga, JA; MacPherson, P; CORBETT, EL;
2023
PLOS global public health
Accuracy of upper respiratory tract samples to diagnose Mycobacterium tuberculosis: a systematic review and meta-analysis.
Savage, HR; Rickman, HM; BURKE, RM; Odland, ML; Savio, M; Ringwald, B; Cuevas, LE; MacPherson, P;
2023
The Lancet. Microbe
Ending AIDS deaths requires improvements in clinical care for people with advanced HIV disease who are seriously ill.
BURKE, RM; Feasey, N; Rangaraj, A; Camps, MR; Meintjes, G; El-Sadr, WM; Ford, N;
2023
The lancet. HIV
Community-level variation in TB testing history: analysis of a prevalence survey in Blantyre, Malawi
NIGHTINGALE, E; Feasey, H; Khundi, M; Soko, RN; BURKE, R; Nliwasa, M; Twabi, H; Mpunga, J; FIELDING, K; MacPherson, P; Corbett, E;
2023
medRxiv
Impact of Community-Wide Tuberculosis Active Case Finding and Human Immunodeficiency Virus Testing on Tuberculosis Trends in Malawi.
BURKE, RM; Nliwasa, M; Dodd, PJ; FEASEY, HR A; Khundi, M; Choko, A; Nzawa-Soko, R; Mpunga, J; WEBB, EL; FIELDING, K; MacPherson, P; CORBETT, EL;
2023
Clinical infectious diseases
Prevalence of Bacteriologically-Confirmed Tuberculosis in Urban Blantyre, Malawi 2019-20: Substantial Decline Compared to 2013-14 National Survey
FEASEY, H; Khundi, M; Nzawa Soko, R; NIGHTINGALE, E; BURKE, R; Henrion, M; Phiri, M; BURCHETT, H; Chiume, L; Nliwasa, M; Twabi, H; Mpunga, J; MacPherson, P; Corbett, E;
2023
medRxiv
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