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Dr Rachael Burke

Research Fellow

Room
359

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I am an Infectious Disease and General (Internal) Medicine registrar, and a Wellcome Trust Clinical PhD fellow.  I am based in Malawi with the Malawi Liverpool Wellcome Clinical Research Programme.  My research interests are in tuberculosis and HIV co-infection, improving infectious disease diagnostics and in reducing in-hospital mortality for people living with HIV in low income settings.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

TB Centre

Research

I am conducting a clinical trial of Computer Aided Screening for Tuberculosis in Low Resource Environments (the CASTLE study).  This will evaluate the utility of chest x-ray with computer aided diagnosis (CAD) for improving tuberculosis diagnosis among people living with HIV at the point of admission to hospital in Malawi.  The trial will also provide information on the prevalance of HIV treatment failure, tuberculosis and other infectious diseases among inpatients at a district general hospital in Malawi.

I am delighted to work with my supervisors Prof Liz Corbett, Dr Peter MacPherson and Dr Ankur Gupta-Wright, as well as advisors and collaborators from College of Medicine Malawi, Liverpool School of Tropical Medicine and LSHTM.

More information about our Malawi Liverpool Wellcome Public Health research group can be found at Dr MacPherson's github page.

Research Area
Clinical trials
Diagnostics
Public health
Evaluation
Randomised controlled trials
Discipline
Epidemiology
Medicine
Disease and Health Conditions
HIV/AIDS
Tuberculosis
Country
Malawi
Region
Sub-Saharan Africa (developing only)

Selected Publications

Impact of community-wide tuberculosis active case finding and HIV testing on tuberculosis trends in Malawi.
Burke RM; Nliwasa M; Dodd PJ; Feasey HR; Khundi M; Choko A; Nzawa-Soko R; Mpunga J; Webb EL; Fielding K
2023
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Interventions to reduce deaths in people living with HIV admitted to hospital in low- and middle-income countries: A systematic review.
Burke RM; Twabi HH; Johnston C; Nliwasa M; Gupta-Wright A; Fielding K; Ford N; MacPherson P; Corbett EL
2023
PLOS Global Public Health
Prevalence of Bacteriologically-Confirmed Tuberculosis in Urban Blantyre, Malawi 2019-20: Substantial Decline Compared to 2013-14 National Survey
Feasey H; Khundi M; Nzawa Soko R; Nightingale E; Burke R; Henrion M; Phiri M; Burchett H; Chiume L; Nliwasa M
2023
medRxiv
Community-level variation in TB testing history: analysis of a prevalence survey in Blantyre, Malawi
Nightingale E; Feasey H; Khundi M; Soko RN; Burke R; Nliwasa M; Twabi H; Mpunga J; Fielding K; MacPherson P
2023
medRxiv
Demand creation for HIV testing services: A systematic review and meta-analysis.
Wagner AD; Njuguna IN; Neary J; Lawley KA; Louden DKN; Tiwari R; Jiang W; Kalu N; Burke RM; Mangale D
2023
PLoS medicine
Neighbourhood prevalence-to-notification ratios for adult bacteriologically-confirmed tuberculosis reveals hotspots of underdiagnosis in Blantyre, Malawi.
Khundi M; Carpenter JR; Corbett EL; Feasey HRA; Soko RN; Nliwasa M; Twabi H; Chiume L; Burke RM; Horton KC
2022
PloS one
Inequalities in the impact of COVID-19-associated disruptions on tuberculosis diagnosis by age and sex in 45 high TB burden countries.
McQuaid CF; Henrion MYR; Burke RM; MacPherson P; Nzawa-Soko R; Horton KC
2022
BMC medicine
Accuracy of upper respiratory tract samples to diagnose Mycobacterium tuberculosis: a systematic review and meta-analysis
Savage H; Rickman H; Burke R; Odland ML; Savio M; Ringwald B; Cuevas L; MacPherson P
2022
medRxiv
See more Publications