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Dr Rachael Burke

Research Fellow

Room
359

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I am an Infectious Disease and General (Internal) Medicine registrar, and a Wellcome Trust Clinical PhD fellow.  I am based in Malawi with the Malawi Liverpool Wellcome Clinical Research Programme.  My research interests are in tuberculosis and HIV co-infection, improving infectious disease diagnostics and in reducing in-hospital mortality for people living with HIV in low income settings.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Clinical Research

Centres

TB Centre

Research

I am conducting a clinical trial of Computer Aided Screening for Tuberculosis in Low Resource Environments (the CASTLE study).  This will evaluate the utility of chest x-ray with computer aided diagnosis (CAD) for improving tuberculosis diagnosis among people living with HIV at the point of admission to hospital in Malawi.  The trial will also provide information on the prevalance of HIV treatment failure, tuberculosis and other infectious diseases among inpatients at a district general hospital in Malawi.

I am delighted to work with my supervisors Prof Liz Corbett, Dr Peter MacPherson and Dr Ankur Gupta-Wright, as well as advisors and collaborators from College of Medicine Malawi, Liverpool School of Tropical Medicine and LSHTM.

More information about our Malawi Liverpool Wellcome Public Health research group can be found at Dr MacPherson's github page.

Research Area
Clinical trials
Diagnostics
Public health
Evaluation
Randomised controlled trials
Discipline
Epidemiology
Medicine
Disease and Health Conditions
HIV/AIDS
Tuberculosis
Country
Malawi
Region
Sub-Saharan Africa (developing only)

Selected Publications

Diagnosing tuberculosis in people with advanced HIV: more is needed.
Burke RM; Gupta Wright A
2021
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Incidence of HIV-positive admission and inpatient mortality in Malawi (2012-2019).
Burke RM; Henrion MYR; Mallewa J; Masamba L; Kalua T; Khundi M; Gupta-Wright A; Rylance J; Gordon SB; Masesa C
2021
AIDS
What is the optimum time to start antiretroviral therapy in people with HIV and tuberculosis coinfection? A systematic review and meta-analysis.
Burke RM; Rickman HM; Singh V; Corbett EL; Ayles H; Jahn A; Hosseinipour MC; Wilkinson RJ; MacPherson P
2021
Journal of the International AIDS Society
Same-day antiretroviral therapy initiation for people living with HIV who have tuberculosis symptoms: a systematic review.
Burke RM; Rickman HM; Singh V; Kalua T; Labhardt ND; Hosseinipour M; Wilkinson RJ; MacPherson P
2021
HIV medicine
Tuberculosis case notifications in Malawi have strong seasonal and weather-related trends.
Kirolos A; Thindwa D; Khundi M; Burke RM; Henrion MYR; Nakamura I; Divala TH; Nliwasa M; Corbett EL; MacPherson P
2021
Scientific reports
Computer-aided X-ray screening for tuberculosis and HIV testing among adults with cough in Malawi (the PROSPECT study): A randomised trial and cost-effectiveness analysis.
MacPherson P; Webb EL; Kamchedzera W; Joekes E; Mjoli G; Lalloo DG; Divala TH; Choko AT; Burke RM; Maheswaran H
2021
PLoS medicine
Effects of Coronavirus Disease Pandemic on Tuberculosis Notifications, Malawi.
Soko RN; Burke RM; Feasey HRA; Sibande W; Nliwasa M; Henrion MYR; Khundi M; Dodd PJ; Ku CC; Kawalazira G
2021
Emerging infectious diseases
Impact of COVID-19 on tuberculosis notifications in Blantyre Malawi: an interrupted time series analysis and qualitative study with healthcare workers.
Soko RN; Burke RM; Feasey HRA; Sibande W; Nliwasa M; Henrion MYR; Khundi M; Dodd PJ; Ku CC; Kawalazira G
2021
medRxiv preprint
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