Professor Gregory Bancroft


of Immunology

K396 south courtyard

Keppel Street
United Kingdom

020 7927 2361

Greg graduated from the University of Western Australia with a BScHons from the laboratory of Prof. Geoffrey Shellam, having completed a research project on the role of NK cells in genetically determined resistance against murine cytomegalovirus.  He completed a PhD at the National Institute for Medical Research Mill Hill, London under the guidance of Dr Ita Askonas on the role of macrophages in immunity to African trypanosomiasis, which started his interests in phagocyte biology and pathways of macrophage activation.  After a four year period studying this topic as a postdoctoral fellow at Harvard Medical School, Boston and Washington University, St Louis with Prof. Emil Unanue, Greg moved to the LSHTM in 1988, initially to study macrophage mediated immunity against the AIDS-related fungal pathogen Cryptococcus neoformans.


Department of Infection Biology
Faculty of Infectious and Tropical Diseases


TB Centre
Vaccine Centre


Greg is the Programme Director for the Immunology of Infectious Diseases MSc, a one year course which trains future immunologists for a career in immunology research or infectious disease.



Greg Bancroft is currently Professor of Immunology at the London School of Hygiene & Tropical Medicine.  He has over 30 years of experience working in the field of infection and immunity.  Greg’s current research relates to understanding the mechanisms of pathogenesis and the development of novel vaccines against two important pathogenic bacteria, M. tuberculosis and B. pseudomallei.  His work in tuberculosis relates to the pre-clinical evaluation for candidate live attenuated TB vaccines through the EU. This is a critical go-no go decision step in the development of the many live attenuated TB vaccines being developed within the EU framework.

He uses similar approaches of experimental modeling, cell mediated immunity and imaging in studies on the causative agent of melioidosis (B. pseudomallei), an important cause of septic death in rural Thailand and Northern Australia.  This work is done primarily with a long standing collaboration with colleagues at Khon Kaen University in the endemic region of Thailand who study human immune responses to this organism and at both Mahidol and Chulalongkorn Universities on melioidosis and tuberculosis.  Much of his work investigating the genetic basis of virulence of B. pseudomallei is in collaboration with Prof. Rick Titball (University of Exeter) and Prof. Brendan Wren (LSHTM).  He is  an Honorary Lecturer at  Mahidol University in Bangkok and Visiting Scholar at Khon Kaen University, Thailand.  In addition he has had long standing collaborations with colleagues in DSTL and at NIMR Mill Hill/Crick, the latter on tuberculosis and now more recently melioidosis research.


Research Area
Disease and Health Conditions
Neglected Tropical Diseases (NTDs)
United Kingdom
Europe & Central Asia (all income levels)

Selected Publications

Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis.
Levillain F; Kim H; Woong Kwon K; Clark S; Cia F; Malaga W; Lanni F; Brodin P; Gicquel B; Guilhot C
Oxidized Carbon Nanosphere-Based Subunit Vaccine Delivery System Elicited Robust Th1 and Cytotoxic T Cell Responses.
Sawutdeechaikul P; Cia F; Bancroft G; Wanichwecharungruang S; Sittplangkoon C; Palaga T
Journal of microbiology and biotechnology
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases
Singhania A; Graham CM; Gabryšová L; Moreira-Teixeira L; Stavropoulos E; Pitt JM; Chakravarty P; Warnatsch A; Branchett WJ; Conejero L
Nature Communications
Genome Resequencing of Laboratory Stocks of Burkholderia pseudomallei K96243.
Wagley S; Scott AE; Ireland PM; Prior JL; Atkins TP; Bancroft GJ; Studholme DJ; Titball RW
Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization.
Kewcharoenwong C; Prabowo SA; Bancroft GJ; Fletcher HA; Lertmemongkolchai G
Frontiers in immunology
Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection.
Pinweha P; Pumirat P; Cuccui J; Jitprasutwit N; Muangsombut V; Srinon V; Boonyuen U; Thiennimitr P; Vattanaviboon P; Cia F
PloS one
TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development.
Kaufmann SHE; Dockrell HM; Drager N; Ho MM; McShane H; Neyrolles O; Ottenhoff THM; Patel B; Roordink D; Spertini F
Frontiers in immunology
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