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Professor Gregory Bancroft

BSc PhD

Professor
of Immunology

Room
K/482

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7927 2361

Greg graduated from the University of Western Australia with a BScHons from the laboratory of Prof. Geoffrey Shellam, having completed a research project on the role of NK cells in genetically determined resistance against murine cytomegalovirus.  He completed a PhD at the National Institute for Medical Research Mill Hill, London under the guidance of Dr Ita Askonas on the role of macrophages in immunity to African trypanosomiasis, which started his interests in phagocyte biology and pathways of macrophage activation.  After a four year period studying this topic as a postdoctoral fellow at Harvard Medical School, Boston and Washington University, St Louis with Prof. Emil Unanue, Greg moved to the LSHTM in 1988, initially to study macrophage mediated immunity against the AIDS-related fungal pathogen Cryptococcus neoformans.

Affiliations

Department of Immunology and Infection
Faculty of Infectious and Tropical Diseases

Centres

Tuberculosis (TB) Centre
Vaccine Centre

Teaching

Greg is the Programme Director for the Immunology of Infectious Diseases MSc, a one year course which trains future immunologists for a career in immunology research or infectious disease.

 

Research

Greg Bancroft is currently Professor of Immunology at the London School of Hygiene & Tropical Medicine.  He has over 30 years of experience working in the field of infection and immunity.  Greg’s current research relates to understanding the mechanisms of pathogenesis and the development of novel vaccines against two important pathogenic bacteria, M. tuberculosis and B. pseudomallei.  His work in tuberculosis relates to the pre-clinical evaluation for candidate live attenuated TB vaccines through the EU. This is a critical go-no go decision step in the development of the many live attenuated TB vaccines being developed within the EU framework.

He uses similar approaches of experimental modeling, cell mediated immunity and imaging in studies on the causative agent of melioidosis (B. pseudomallei), an important cause of septic death in rural Thailand and Northern Australia.  This work is done primarily with a long standing collaboration with colleagues at Khon Kaen University in the endemic region of Thailand who study human immune responses to this organism and at both Mahidol and Chulalongkorn Universities on melioidosis and tuberculosis.  Much of his work investigating the genetic basis of virulence of B. pseudomallei is in collaboration with Prof. Rick Titball (University of Exeter) and Prof. Brendan Wren (LSHTM).  He is  an Honorary Lecturer at  Mahidol University in Bangkok and Visiting Scholar at Khon Kaen University, Thailand.  In addition he has had long standing collaborations with colleagues in DSTL and at NIMR Mill Hill/Crick, the latter on tuberculosis and now more recently melioidosis research.

 

Research Area
Vaccines
Discipline
Immunology
Disease and Health Conditions
Tuberculosis
Melioidosis
Neglected Tropical Diseases (NTDs)
Country
United Kingdom
Thailand
Region
Europe & Central Asia (all income levels)

Selected Publications

Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection.
Pinweha, P. ; Pumirat, P. ; Cuccui, J. ; Jitprasutwit, N. ; Muangsombut, V. ; Srinon, V. ; Boonyuen, U. ; Thiennimitr, P. ; Vattanaviboon, P. ; Cia, F. ; Willcocks, S. ; Bancroft, G.J. ; Wren, B.W. ; Korbsrisate, S. ;
2018
PLoS One
Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei.
Kessler, B. ; Rinchai, D. ; Kewcharoenwong, C. ; Nithichanon, A. ; Biggart, R. ; Hawrylowicz, C.M. ; Bancroft, G.J. ; Lertmemongkolchai, G. ;
2017
Sci Rep
Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?
Titball, R.W. ; Burtnick, M.N. ; Bancroft, G.J. ; Brett, P. ;
2017
Vaccine
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection.
Sayes, F. ; Pawlik, A. ; Frigui, W. ; Gröschel, M.I. ; Crommelynck, S. ; Fayolle, C. ; Cia, F. ; Bancroft, G.J. ; Bottai, D. ; Leclerc, C. ; Brosch, R. ; Majlessi, L. ;
2016
PLoS Pathog
Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages.
Howes, A. ; Taubert, C. ; Blankley, S. ; Spink, N. ; Wu, X. ; Graham, C.M. ; Zhao, J. ; Saraiva, M. ; Ricciardi-Castagnoli, P. ; Bancroft, G.J. ; O'Garra, A. ;
2016
J Immunol
Glibenclamide impairs responses of neutrophils against Burkholderia pseudomallei by reduction of intracellular glutathione.
Kewcharoenwong, C. ; Rinchai, D. ; Nithichanon, A. ; Bancroft, G.J. ; Ato, M. ; Lertmemongkolchai, G. ;
2016
Sci Rep
The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease.
Conejero, L. ; Potempa, K. ; Graham, C.M. ; Spink, N. ; Blankley, S. ; Salguero, F.J. ; Pankla-Sranujit, R. ; Khaenam, P. ; Banchereau, J.F. ; Pascual, V. ; Chaussabel, D. ; Lertmemongkolchai, G. ; O'Garra, A. ; Bancroft, G.J. ;
2015
J Immunol
CD4+ T Cell Epitopes of FliC Conserved between Strains of Burkholderia: Implications for Vaccines against Melioidosis and Cepacia Complex in Cystic Fibrosis.
Musson, J.A. ; Reynolds, C.J. ; Rinchai, D. ; Nithichanon, A. ; Khaenam, P. ; Favry, E. ; Spink, N. ; Chu, K.K. ; De Soyza, A. ; Bancroft, G.J. ; Lertmemongkolchai, G. ; Maillere, B. ; Boyton, R.J. ; Altmann, D.M. ; Robinson, J.H. ;
2014
J Immunol
See all Professor Gregory Bancroft's Publications