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Professor Cally Roper

BSc PhD

Professor
in Malaria Genetics

My research applies evolutionary genetics to address practical problems in malaria control focussing in particular on the threat of antimalarial drug resistance. My current projects include the development of a genetic barcode, mapping resistance mutations in Africa to inform policy on malaria prevention in pregnant women (IPTp), measuring levels of drug selection in the field applied by different treatment policies, and assessing the role of human migration in the dispersal of drug resistant malaria.

 

 

 

Affiliations

Department of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre

Teaching

Module organiser for the distance learning Malaria module.

Research

Barcoding Malaria Parasites: A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.  M.D. Preston, S. Campino, S.A. Assefa, D.F. Echeverry, H. Ocholla, A. Amambua-Ngwa, L. Stewart, D.J. Conway, S. Borrmann, P. Michon, I. Zongo, J-B Ouédraogo, A.A. Djimde, O.K. Doumbo, F. Nosten, A. Pain, T. Bousema, C.J. Drakeley, R.M. Fairhurst, C.J. Sutherland, C. Roper, T.G Clark.   Nature Communications (2014) 5:4052.

Mapping the spread of drug resistance mutations in Africa  http://www.drugresistancemaps.org/   Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria. R. J. Pearce, H. Pota, M-S B. Evehe, E-H Bâ, G. Mombo-Ngoma, A. L. Malisa, R. Ord, W. Inojosa, A. Matondo, D.A. Diallo, W. Mbacham, I.V.van den Broek, T.D. Swarthout, A. Getachew, S. Dejene, M.P.Grobusch, F. Njie, S. Dunyo, M. Kweku, S. Owusu-Agyei, D. Chandramohan, M. Bonnet, J-P Guthmann, S. Clarke, K.I. Barnes, E. Streat, S.T. Katokele, P. Uusiku, C.O. Agboghoroma, O. Y. Elegba, B. Cissé, I. E. A-Elbasit, H.A. Giha, S.P. Kachur, C. Lynch, J.B. Rwakimari, P. Chanda, M. Hawela, B. Sharp, I. Naidoo, C. Roper.   PLoS Medicine (2009) 6(4):e1000055

Measuring drug pressure in a field trial of intermittent preventive treatment of infants (IPTi). A community-randomised evaluation of the effect of IPTi on antimalarial drug resistance in southern Tanzania. R. J. Pearce , R. Ord, H. Kaur, C. Lupala , J. Schellenberg, K. Shirma, F. Manzi, M. Tanner, P. Alonso, H. Mshinda, C. Roper, D. Schellenberg. The Journal of Infectious Diseases (2013) 207, 849-859. 
 

 

Research Area
Drug resistance
Discipline
Molecular epidemiology
Genetics
GIS/Spatial analysis
Molecular biology
Disease and Health Conditions
Infectious disease
Malaria
Country
Burkina Faso
China
Cameroon
Congo, Dem. Rep.
Congo, Rep.
Colombia
Ethiopia
Gabon
United Kingdom
Ghana
Guinea
Gambia, The
India
Kenya
Sri Lanka
Mozambique
Namibia
Senegal
South Sudan
Tanzania
South Africa
Zambia
Region
Sub-Saharan Africa (all income levels)
World

Selected Publications

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.
Preston, M.D.; Campino, S.; Assefa, S.A.; Echeverry, D.F.; Ocholla, H.; Amambua-Ngwa, A.; Stewart, L.B.; Conway, D.J.; Borrmann, S.; Michon, P.; Zongo, I.; Ouédraogo, J.B.; Djimde, A.A.; Doumbo, O.K.; Nosten, F.; Pain, A.; Bousema, T.; Drakeley, C.J.; Fairhurst, R.M.; Sutherland, C.J.; Roper, C.; Clark, T.G.;
Nat Commun
Molecular surveillance for artemisinin resistance in Africa
Roper, C.; Alifrangis, M.; Ariey, F.; Talisuna, A.; Menard, D.; Mercereau-Puijalon, O.; Ringwald, P.
Lancet Infectious Diseases
Independent Origin of Plasmodium falciparum Antifolate Super-Resistance, Uganda, Tanzania, and Ethiopia
Alifrangis, M.; Nag, S.; Schousboe, M.L.; Ishengoma, D.; Lusingu, J.; Pota, H.; Kavishe, R.A.; Pearce, R.; Ord, R.; Lynch, C.; Dejene, S.; Cox, J.; Rwakimari, J.; Minja, D.T.R.; Lemnge, M.M.; Roper, C.
Emerging Infectious Diseases
Global and local genetic diversity at two microsatellite loci in Plasmodium vivax parasites from Asia, Africa and South America.
Schousboe, M.L. ; Ranjitkar, S. ; Rajakaruna, R.S. ; Amerasinghe, P.H. ; Konradsen, F. ; Morales, F. ; Ord, R. ; Pearce, R. ; Leslie, T. ; Rowland, M. ; Gadalla, N. ; Bygbjerg, I.C. ; Alifrangis, M. ; Roper, C. ;
Malar J
Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.
Pearce, R.J.; Pota, H.; Evehe, M.S.; Bâ, e.l.-.H.; Mombo-Ngoma, G.; Malisa, A.L.; Ord, R.; Inojosa, W.; Matondo, A.; Diallo, D.A.; Mbacham, W.; van den Broek, I.V.; Swarthout, T.D.; Getachew, A.; Dejene, S.; Grobusch, M.P.; Njie, F.; Dunyo, S.; Kweku, M.; Owusu-Agyei, S.; Chandramohan, D.; Bonnet, M.; Guthmann, J.P.; Clarke, S.; Barnes, K.I.; Streat, E.; Katokele, S.T.; Uusiku, P.; Agboghoroma, C.O.; Elegba, O.Y.; Cissé, B.; A-Elbasit, I.E.; Giha, H.A.; Kachur, S.P.; Lynch, C.; Rwakimari, J.B.; Chanda, P.; Hawela, M.; Sharp, B.; Naidoo, I.; Roper, C.;
PLoS Med
Intercontinental spread of pyrimethamine-resistant malaria.
Roper, C.; Pearce, R.; Nair, S.; Sharp, B.; Nosten, F.; Anderson, T.;
Science
Antifolate antimalarial resistance in southeast Africa: a population-based analysis
Roper, C.; Pearce, R.; Bredenkamp, B.; Gumede, J.; Drakeley, C.; Mosha, F.; Chandramohan, D.; Sharp, B.
Lancet
See all Professor Cally Roper's Publications