Prof Cally Roper

Professor of Malaria Genetics

London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom

Email
Cally

My research applies evolutionary genetics to practical problems in malaria control. In particular I am interested in the emergence and spread of antimalarial drug resistance. My research involves mapping resistance in Africa to show patterns of mutation dispersal, and to inform policy on drug use for chemoprevention and treatment.

Affiliations

Department of Infection Biology

Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre

Antimicrobial Resistance Centre

Teaching

I am a module organiser for the Malaria Module in the DL MSc in Infectious Diseases IDM503.

Research

Im currently working on the Plus Project, where my role is to lead the genotyping work package. We are mapping the genetic determinants of antimalarial drug resistance in 7 Countries and determining the suitability of Sulphadoxine Pyrimethamine (SP) for Perennial Malaria Chemoprevention (PMC).

Selected Publications

Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether-lumefantrine and artesunate-amodiaquine in Africa.

Okell, LC; Reiter, LM; Ebbe, LS; Baraka, V; Bisanzio, D; Watson, OJ; Bennett, A; Verity, R; Gething, P; ROPER, C; Alifrangis, M;

2018

BMJ global health

Molecular determinants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum in Nigeria and the regional emergence of dhps 431V.

OGUIKE, MC; Falade, CO; Shu, E; Enato, IG; Watila, I; Baba, ES; BRUCE, J; WEBSTER, J; Hamade, P; Meek, S; CHANDRAMOHAN, D; SUTHERLAND, CJ; WARHURST, D; ROPER, C;

2016

International journal for parasitology Drugs and drug resistance

Independent origin of plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia.

Alifrangis, M; Nag, S; Schousboe, ML; Ishengoma, D; Lusingu, J; Pota, H; Kavishe, RA; Pearce, R; Ord, R; LYNCH, C; Dejene, S; COX, J; Rwakimari, J; Minja, DT R; Lemnge, MM; ROPER, C;

2014

Emerging infectious diseases

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.

PRESTON, MD; CAMPINO, S; ASSEFA, SA; Echeverry, DF; Ocholla, H; AMAMBUA-NGWA, A; STEWART, LB; CONWAY, DJ; Borrmann, S; Michon, P; Zongo, I; Ouédraogo, J-B; Djimde, AA; Doumbo, OK; Nosten, F; Pain, A; BOUSEMA, T; DRAKELEY, CJ; Fairhurst, RM; SUTHERLAND, CJ; ROPER, C; CLARK, TG;

2014

Nature communications

Mapping 'partially resistant', 'fully resistant', and 'super resistant' malaria.

Naidoo, I; ROPER, C;

2013

Trends in parasitology

Drug resistance maps to guide intermittent preventive treatment of malaria in African infants.

Naidoo, I; ROPER, C;

2011

Parasitology

The transit phase of migration: circulation of malaria and its multidrug-resistant forms in Africa.

LYNCH, C; ROPER, C;

2011

PLoS medicine

Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.

Pearce, RJ; Pota, H; Evehe, M-SB; Bâ, E-H; Mombo-Ngoma, G; Malisa, AL; Ord, R; Inojosa, W; Matondo, A; Diallo, DA; Mbacham, W; Van den Broek, IV; Swarthout, TD; Getachew, A; Dejene, S; Grobusch, MP; NJIE, F; Dunyo, S; Kweku, M; OWUSU-AGYEI, S; CHANDRAMOHAN, D; Bonnet, M; Guthmann, J-P; CLARKE, S; Barnes, KI; ... ROPER, C.

2009

PLoS medicine

The origins and spread of antimalarial drug resistance: lessons for policy makers.

Anderson, TJ C; ROPER, C;

2005

Acta tropica

Intercontinental spread of pyrimethamine-resistant malaria.

ROPER, C; Pearce, R; Nair, S; Sharp, B; Nosten, F; Anderson, T;

2004

Science (New York, NY)

See more information

Contact