Below is a selection of highlighted research projects and papers related to the AMR Centre.
Estimating Vaccine-Avertible Antibiotic Use
Estimating the extent to which vaccines can be used to reduce antibiotic consumption in the community and in healthcare settings, to better account for the value of vaccination programmes.
LSHTM staff: Nick Davies, Mark Jit
Funding: WHO
Collaborators: WHO
Project duration: 2020 - 2020
Every dog has its data. Canine Leptospirosis: Machine learning methods for VetCompass and laboratory data linkage
Analysis of antimicrobial sensitivity testing data, machine learning linkage to existing VetCompass data, and evaluation of linkage performance.
LSHTM staff: Sam Clifford, David Brodbelt
Funding: Bloomsbury SET
Collaborators: Royal Veterinary College, University of Sunderland
Project duration: 2019 - 2020
The Economic and Societal Burden of Antibiotic Resistance
Estimating the incremental impact of antibiotic resistance globally, through information retrieval and evidence synthesis methods.
LSHTM staff: Nichola Naylor, Mark Jit
Funding: WHO
Collaborators: WHO
Project duration: 2020 - 2020
Evaluating the impact of antibiotic resistance-related interventions from a One Health perspective
Evaluating the potential impact of interventions to reduce antimicrobial use in livestock on human antimicrobial resistance and drug-resistant infections, with a focus on how to evaluate these from a One Health Economics perspective. An evaluation framework and toolkit are being developed as part of this project.
LSHTM staff: Jo Lines, Jeff Waage, Nichola Naylor, Gwen Knight, Maria Bernardez
Funding: CGIAR
Collaborators: International Livestock Research Institute (ILRI)
Project duration: 2019 - 2021
Optimizing health systems to improve delivery of decentralized care for patients with drug-resistant tuberculosis
This project uses analysis of patient pathways to understand how DRTB care has been decentralised in three provinces of South Africa, aiming to identify what health system factors contribute to effective DRTB care.
LSHTM staff: Alison Grant
Funding: MRC
Collaborators: University of Cape Town, AHRI, UKZN, South African MRC, QMU
Project duration: 2016 - 2020
A randomized open-label trial to evaluate the efficacy of periodic high dose rifapentine and INH for three months compared to continuous INH preventive therapy in HIV-infected and TB-infected individuals in South Africa
A randomised controlled trial comparing a single course of IPT to periodic rifapentine and isoniazid for TB prevention among HIV-positive people.
LSHTM staff: Katherine Fielding, Alison Grant
Funding: USAID
Collaborators: Aurum Institute
Project duration: 2016 - 2020
Drivers of drug resistance in Uganda and Malawi
LSHTM staff: Nick Feasey, Clare Chandler
Funding: MRC
Collaborators: Liverpool School of Tropical Medicine, Wellcome Sanger Institute, Infectious Diseases Institute Makerere University, UK Centre for Ecology and Hydrology, African Institute for Development Policy, Malawi-Liverpool-Wellcome Trust Clinical Research Programme
Project duration: 2019 - 2021
Fleming Fund Fellowships - addressing the priority areas of AMR and AMU surveillance, and laboratory quality management
LSHTM staff: Richard Stabler, Clare Chandler, Catherine Goodman, Katharina Kranzer, Justin Dixon, Sam Willcocks, Alex Aiken, Naomi Bull
Funding: DHSC (Mott Macdonald)
Project duration: 2018 - 2021
The International Network for AMR Social Science (INAMRSS)
LSHTM staff: Clare Chandler
Funding: -
Project duration: 2020 -
Capacity Sharing for AntiMicrobial Stewardship (CaSAMS)
LSHTM staff: Clare Chandler, Sarah Staedke, Nick Brown
Funding: DHSC (THET)
Collaborators: IDRC, UCLH, Manchester Change Exchange
Project duration: 2019 - 2020