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Dr Andrea Zelmer

Assistant Professor

Room
Room 490

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)207 958 8269

After obtaining a degree in Biology at the Technical University of Braunschweig, Germany I completed my PhD at the Helmholtz Centre for Infection Research in Braunschweig where I worked on "Intracellular Bacteria as Vectors for Gene Transfer in vitro and in vivo". I then moved to the UCL School of Pharmacy as a postdoctoral researcher where I focussed on a rat model of E. coli K1 infection in neonates and treatment thereof in keeping with the theme of bacterial infections. I joined the School in June 2008 to set up an in vivo imaging system to facilitate testing of anti-tuberculosis drugs.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

Tuberculosis (TB) Centre
Vaccine Centre

Teaching

Distance learning tutor Infectious Diseases/Principles of Biology

Research

My current research focuses on vaccines and treatments for tuberculosis, with emphasis on development of clinically relevant in vivo models and ex vivo mycobacterial growth inhibition assays (MGIA), and use of these to test tuberculosis vaccines and elucidate mechanisms by which they work or fail in certain populations. The efficacy of Bacille Calmette-Guerin (BCG), the only licensed vaccine against TB, is highly variable. I am interested in the host response to BCG to help us understand how the vaccine protects from disease, and why sometimes it doesn’t. 

I also have a keen interest in application and development of optical imaging methods.

Research Area
Bacteria
Innate immunity
Vaccines
Immunisation
Discipline
Immunology
Microbiology
Disease and Health Conditions
Infectious disease
Tuberculosis

Selected Publications

Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis.
Sander, P. ; Clark, S. ; Petrera, A. ; Vilaplana, C. ; Meuli, M. ; Selchow, P. ; Zelmer, A. ; Mohanan, D. ; Andreu, N. ; Rayner, E. ; Dal Molin, M. ; Bancroft, G.J. ; Johansen, P. ; Cardona, P.J. ; Williams, A. ; Böttger, E.C. ;
2015
Vaccine
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system.
Bottai, D. ; Frigui, W. ; Clark, S. ; Rayner, E. ; Zelmer, A. ; Andreu, N. ; de Jonge, M.I. ; Bancroft, G.J. ; Williams, A. ; Brodin, P. ; Brosch, R. ;
2015
Vaccine
Rapid in vivo assessment of drug efficacy against Mycobacterium tuberculosis using an improved firefly luciferase.
Andreu, N.; Zelmer, A.; Sampson, S.L.; Ikeh, M.; Bancroft, G.J.; Schaible, U.E.; Wiles, S.; Robertson, B.D.;
2013
J Antimicrob Chemother
Noninvasive fluorescence imaging of small animals.
Zelmer, A.; Ward, T.H.;
2013
J Microsc
A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging.
Zelmer, A. ; Carroll, P. ; Andreu, N. ; Hagens, K. ; Mahlo, J. ; Redinger, N. ; Robertson, B.D. ; Wiles, S. ; Ward, T.H. ; Parish, T. ; Ripoll, J. ; Bancroft, G.J. ; Schaible, U.E. ;
2012
J Antimicrob Chemother
Noninvasive biophotonic imaging for studies of infectious disease.
Andreu, N.; Zelmer, A.; Wiles, S.;
2011
FEMS Microbiol Rev
Administration of Capsule-Selective Endosialidase E Minimises Up-Regulation of Organ Gene Expression Induced by Experimental Systemic Infection with Escherichia coli K1.
Zelmer, A.; Martin, M.J.; Gundogdu, O.; Birchenough, G.; Lever, R.; Wren, B.W.; Luzio, J.P.; Taylor, P.W.;
2010
Microbiology
Optimisation of bioluminescent reporters for use with mycobacteria.
Andreu, N.; Zelmer, A.; Fletcher, T.; Elkington, P.T.; Ward, T.H.; Ripoll, J.; Parish, T.; Bancroft, G.J.; Schaible, U.; Robertson, B.D.; Wiles, S.;
2010
PLoS One
See all Dr Andrea Zelmer's Publications