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Dr Andrea Zelmer

Assistant Professor

Room
Room 490

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)207 958 8269

After obtaining a degree in Biology at the Technical University of Braunschweig, Germany I completed my PhD at the Helmholtz Centre for Infection Research in Braunschweig where I worked on "Intracellular Bacteria as Vectors for Gene Transfer in vitro and in vivo". I then moved to the UCL School of Pharmacy as a postdoctoral researcher where I focussed on a rat model of E. coli K1 infection in neonates and treatment thereof in keeping with the theme of bacterial infections. I joined the School in June 2008 to set up an in vivo imaging system to facilitate testing of anti-tuberculosis drugs.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

Tuberculosis (TB) Centre
Vaccine Centre

Teaching

Distance learning tutor Infectious Diseases/Principles of Biology

Research

My current research focuses on vaccines and treatments for tuberculosis, with emphasis on development of clinically relevant in vivo models and ex vivo mycobacterial growth inhibition assays (MGIA), and use of these to test tuberculosis vaccines and elucidate mechanisms by which they work or fail in certain populations. The efficacy of Bacille Calmette-Guerin (BCG), the only licensed vaccine against TB, is highly variable. I am interested in the host response to BCG to help us understand how the vaccine protects from disease, and why sometimes it doesn’t. 

I also have a keen interest in application and development of optical imaging methods.

Research Area
Bacteria
Innate immunity
Vaccines
Immunisation
Discipline
Immunology
Microbiology
Disease and Health Conditions
Infectious disease
Tuberculosis

Selected Publications

RUTI Vaccination Enhances Inhibition of Mycobacterial Growth ex vivo and Induces a Shift of Monocyte Phenotype in Mice
Prabowo SA; Painter H; Zelmer A; Smith SG; Seifert K; Amat M; Cardona P-J; Fletcher HA
2019
Frontiers in Immunology
Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells
Prabowo SA; Zelmer A; Stockdale L; Ojha U; Smith SG; Seifert K; Fletcher HA
2019
SCIENTIFIC REPORTS
In vitro mycobacterial growth inhibition in South Korean adults with latent TB infection
Lee H; Kim J; Kang YA; Kim DR; Sim B; Zelmer A; Fletcher HA; Dockrell HM; Smith SG; Cho S-N
2019
Frontiers in Immunology
High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis.
Zelmer A; Stockdale L; Prabowo SA; Cia F; Spink N; Gibb M; Eddaoudi A; Fletcher HA
2018
F1000Research
The Cross-species Mycobacterial Growth Inhibition Assay (MGIA) Project 2010-2014.
Brennan MJ; Tanner R; Morris S; Scriba TJ; Achkar JM; Zelmer A; Hokey D; Izzo A; Sharpe S; Williams A
2017
Clinical and vaccine immunology
A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis.
Zelmer A; Tanner R; Stylianou E; Damelang T; Morris S; Izzo A; Williams A; Sharpe S; Pepponi I; Walker B
2016
BMC infectious diseases
The TB vaccine H56+IC31 dose-response curve is peaked not saturating: Data generation for new mathematical modelling methods to inform vaccine dose decisions.
Rhodes SJ; Zelmer A; Knight GM; Prabowo SA; Stockdale L; Evans TG; Lindenstrøm T; White RG; Fletcher H
2016
Vaccine
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system.
Bottai D; Frigui W; Clark S; Rayner E; Zelmer A; Andreu N; de Jonge MI; Bancroft GJ; Williams A; Brodin P
2015
Vaccine
Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis.
Sander P; Clark S; Petrera A; Vilaplana C; Meuli M; Selchow P; Zelmer A; Mohanan D; Andreu N; Rayner E
2015
Vaccine
Rapid in vivo assessment of drug efficacy against Mycobacterium tuberculosis using an improved firefly luciferase.
Andreu N; Zelmer A; Sampson SL; Ikeh M; Bancroft GJ; Schaible UE; Wiles S; Robertson BD
2013
The Journal of antimicrobial chemotherapy
Noninvasive fluorescence imaging of small animals.
Zelmer A; Ward TH
2013
Journal of microscopy
A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging.
Zelmer A; Carroll P; Andreu N; Hagens K; Mahlo J; Redinger N; Robertson BD; Wiles S; Ward TH; Parish T
2012
The Journal of antimicrobial chemotherapy
Noninvasive biophotonic imaging for studies of infectious disease.
Andreu N; Zelmer A; Wiles S
2011
FEMS microbiology reviews
Optimisation of bioluminescent reporters for use with mycobacteria.
Andreu N; Zelmer A; Fletcher T; Elkington PT; Ward TH; Ripoll J; Parish T; Bancroft GJ; Schaible U; Robertson BD
2010
PloS one
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