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Dr Laith Yakob

BSc MSc DPhil

Associate Professor

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44(0)207 927 2684

I am particularly interested in the epidemiology of infectious diseases and in novel technologies for their control. Main research themes include the relationships between climate and disease ecology, cutting-edge methods for combatting diseases (vaccines, integrated control strategy) and disease vectors (systemic insecticides, Wolbachia and genetic control). My research centres at the confluence of the lab, the field and computational modelling.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Disease Control

Centres

Malaria Centre
Centre for the Mathematical Modelling of Infectious Diseases (CMMID)
Antimicrobial Resistance Centre (AMR)

Teaching

I am on the Senate Postgraduate Taught Committee. I am both the Exam Board Chair and the Deputy Course Director for the MSc in Medical Parasitology (MP) and in Medical Entomology for Disease Control (MEDiC). I co-organise the core modules and field trips for MP and MEDiC.

Research

I am one of the founding eight core members of the UK Public Health Rapid Support Team, who support countries responding to and controlling disease outbreaks before they can develop into a global threat. I am also a founding member of the Antimicrobial Resistance Centre at LSHTM, where I previously acted as the disciplinary head for Epidemiology and Modelling.

 

ACTIVE RESEARCH PROJECTS:

2019-2021
Modelling the impact of a transmission blocking vaccine against leishmaniasis on sand fly vectorial capacity
VALIDATE Network Grant

2018-2021
Early warning systems for dengue outbreaks in SE Asia and Australia
NHMRC (PI Wenbiao Hu; Co-Is: Yakob, Devine, Tu).

2017-2021
New vectors, new diseases: the risk of chikungunya transmission in Australia
NHMRC (PI Francesca Frentiu; Co-Is: Hu, Devine, Yakob, McGraw). 

2017-2021
ZIKAPLAN: Zika Preparedness Latin American Network
ERC-funded Consortium (PI Annelise Wilder-Smith; large network of Co-Is including Yakob).

 

Research Area
Climate change
Complex interventions
Decision analysis
Helminths
Insects
Parasites
Systematic reviews
Disease control
Global Health
Outbreaks
Protozoa
Vector control
Modelling
Discipline
Epidemiology
Mathematical modelling
Parasitology
Vector biology
Entomology
Disease and Health Conditions
Diarrhoeal diseases
Infectious disease
Malaria
Pandemic diseases
African trypanosomiasis
Dengue
Emerging Infectious Disease
Hospital acquired infection
Influenza
Neglected Tropical Diseases (NTDs)
Respiratory disease
Schistosomiasis
Tropical diseases
Vector borne disease
Zoonotic disease

Selected Publications

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis.
Sterkel M; Haines LR; Casas-Sánchez A; Owino Adung'a V; Vionette-Amaral RJ; Quek S; Rose C; Silva Dos Santos M; García Escude N; Ismail HM
2021
PLoS biology
The cost-effectiveness of controlling dengue in Indonesia using wMel Wolbachia released at scale: a modelling study.
Brady OJ; Kharisma DD; Wilastonegoro NN; O'Reilly KM; Hendrickx E; Bastos LS; Yakob L; Shepard DS
2020
BMC medicine
Glycan–glycan interactions determine Leishmania attachment to the midgut of permissive sand fly vectors
Hall AR; Blakeman JT; Eissa AM; Chapman P; Morales-García AL; Stennett L; Martin O; Giraud E; Dockrell DH; Cameron NR
2020
CHEMICAL SCIENCE
The importance of saturating density dependence for predicting SARS-CoV-2 resurgence
Nightingale ES; Brady OJ; Yakob L
2020
medRxiv preprint - BMJ Yale
Evidence of extrinsic factors dominating intrinsic blood host preferences of major African malaria vectors.
Orsborne J; Mohammed AR; Jeffries CL; Kristan M; Afrane YA; Walker T; Yakob L
2020
Scientific Reports
Optimising systemic insecticide use to improve malaria control.
Meredith HR; Furuya-Kanamori L; Yakob L
2019
BMJ Global Health
Estimating the burden of dengue and the impact of release of wMel Wolbachia-infected mosquitoes in Indonesia: a modelling study.
O'Reilly KM; Hendrickx E; Kharisma DD; Wilastonegoro NN; Carrington LB; Elyazar IRF; Kucharski AJ; Lowe R; Flasche S; Pigott DM
2019
BMC medicine
Economic evaluation of interventions designed to reduce Clostridium difficile infection.
Brain D; Yakob L; Barnett A; Riley T; Clements A; Halton K; Graves N
2018
PloS one
Heterogeneous and Dynamic Prevalence of Asymptomatic Influenza Virus Infections.
Furuya-Kanamori L; Yakob L
2018
Emerging infectious diseases
Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission.
Guelbéogo WM; Gonçalves BP; Grignard L; Bradley J; Serme SS; Hellewell J; Lanke K; Zongo S; Sepúlveda N; Soulama I
2018
eLife
Projecting the end of the Zika virus epidemic in Latin America: a modelling analysis.
O'Reilly KM; Lowe R; Edmunds WJ; Mayaud P; Kucharski A; Eggo RM; Funk S; Bhatia D; Khan K; Kraemer MUG
2018
BMC medicine
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