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Dr Catherine Wedderburn

Research Student - MPhil/PhD - Infectious & Tropical Diseases

United Kingdom

I am a Wellcome Trust Clinical Research Fellow at the London School of Hygiene & Tropical Medicine (LSHTM) with an interest in Paediatrics, HIV and Neuroscience. I am conducting my PhD in South Africa examining the effects of HIV and antiretroviral therapy exposure in uninfected children born to HIV-infected mothers. My research aims to understand the impact of in utero and early life exposures on long-term health outcomes.

I have a Masters in Tropical Medicine and International Health and a Diploma in Tropical Medicine & Hygiene from LSHTM and work in the UK and South Africa. Prior to my PhD I worked on a joint project with LSHTM and the WHO on the dual elimination of mother-to-child transmission of HIV and syphilis initiative and developed an online dashboard to monitor progress towards this goal. While at the International Diagnosics Centre, LSHTM, I was the co-ordinator of the Early Infant Diagnosis of HIV (EID) Consortium (http://eidconsortium.org) which brings together principal investigators and partners working in the field of early infant diagnosis and point-of-care. More recently I have also worked for Médecins Sans Frontières in Khayelitsha, Western Cape, South Africa in the field of maternal and paediatric HIV.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I am supervising MSc students in Public Health and Epidemiology.

Research

I am doing my PhD on the ‘Neurodevelopmental effects of HIV and ART exposure: a prospective neuroimaging study of uninfected children born to HIV-infected mothers’ in South Africa funded by a Wellcome Trust Research Training Fellowship. My research involves magnetic resonance imaging of young children and measuring their clinical neurodevelopment with the aim to understand the effects of in utero exposure to HIV and antiretroviral treatment in order to improve global child health. I was awarded the Johnstone & Florence Stoney Studentship from the British Federation of Women Graduates for the research

Research Area
Child health
Clinical research
Diagnostics
Global health
Health education and promotion
Neurology
Maternal health
Medicines
Disease and Health Conditions
HIV/AIDS
Neurological diseases
Disability
Meningitis
Syphilis
Country
South Africa
United Kingdom
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Cytomegalovirus acquisition in infancy and the risk of tuberculosis disease in childhood: a longitudinal birth cohort study in Cape Town, South Africa.
Martinez, L; Nicol, MP; WEDDERBURN, CJ; Stadler, A; Botha, M; Workman, L; Le Roux, DM; Zar, HJ;
2021
The Lancet. Global health
Serology testing in the COVID-19 pandemic response.
PEELING, RW; WEDDERBURN, CJ; Garcia, PJ; Boeras, D; FONGWEN, N; Nkengasong, J; Sall, A; Tanuri, A; HEYMANN, DL;
2020
The Lancet. Infectious diseases
Neuroimaging young children and associations with neurocognitive development in a South African birth cohort study.
WEDDERBURN, CJ; Subramoney, S; YEUNG, S; Fouche, J-P; Joshi, SH; Narr, KL; REHMAN, AM; Roos, A; Ipser, J; Robertson, FC; Groenewold, NA; Gibb, DM; Zar, HJ; Stein, DJ; Donald, KA;
2020
NeuroImage
Newborn Differential DNA Methylation and Subcortical Brain Volumes as Early Signs of Severe Neurodevelopmental Delay in a South African Birth Cohort Study
Hüls, A; WEDDERBURN, C; Groenewold, N; Gladish, N; Jones, M; Koen, N; MacIsaac, J; Lin, DT S; Ramadori, K; Epstein, M; Donald, K; Kobor, M; Zar, H; Stein, D;
2020
medRxiv
The impact of health programmes to prevent vertical transmission of HIV. Advances, emerging health challenges and research priorities for children exposed to or living with HIV: Perspectives from South Africa.
Goga, A; Slogrove, A; WEDDERBURN, CJ; Feucht, U; Wessels, J; Ramokolo, V; Bhana, A; Du Plessis, N; Green, RJ; Pillay, Y; Sherman, G;
2019
South African Medical Journal
Growth and Neurodevelopment of HIV-Exposed Uninfected Children: a Conceptual Framework.
WEDDERBURN, CJ; Evans, C; YEUNG, S; Gibb, DM; Donald, KA; Prendergast, AJ;
2019
Current HIV/AIDS Reports
Impact of HIV and antiretroviral drug exposure on lung growth and function over 2 years in an African Birth Cohort.
Gray, DM; WEDDERBURN, CJ; MacGinty, RP; McMillan, L; Jacobs, C; Stadler, JA M; Hall, GL; Zar, HJ;
2019
AIDS (London, England)
Risk and protective factors for child development: An observational South African birth cohort.
Donald, KA; WEDDERBURN, CJ; Barnett, W; Nhapi, RT; REHMAN, AM; Stadler, JA M; Hoffman, N; Koen, N; Zar, HJ; Stein, DJ;
2019
PLOS Medicine
Neurodevelopment of HIV-exposed uninfected children in South Africa: outcomes from an observational birth cohort study.
WEDDERBURN, CJ; YEUNG, S; REHMAN, AM; Stadler, JA M; Nhapi, RT; Barnett, W; Myer, L; Gibb, DM; Zar, HJ; Stein, DJ; Donald, KA;
2019
The Lancet Child & Adolescent Health
Drakenstein Child Health Study (DCHS): investigating determinants of early child development and cognition.
Donald, KA; Hoogenhout, M; Du Plooy, CP; WEDDERBURN, CJ; Nhapi, RT; Barnett, W; Hoffman, N; Malcolm-Smith, S; Zar, HJ; Stein, DJ;
2018
BMJ paediatrics open
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