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Dr Sam Wassmer

Ph.D.

Associate Professor
in Malaria Pathogenesis

Room
K/236

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7612 7888

Following the completion of his Ph.D. in Marseille, Sam Wassmer joined the Liverpool School of Tropical Medicine in 2005, as a post-doctoral fellow. He was based at the Malawi-Liverpool-Wellcome Trust Clinical Research Programme in Blantyre, and was awarded a Wellcome Trust Research Training Fellowship in 2007 to investigate the influence of endothelial responsiveness to TNF on malaria severity and outcome. In parallel, he contributed to seminal work on the pivotal role of endothelial protein C receptor in fatal paediatric cerebral malaria, associating for the first time coagulation and inflammation with parasite sequestration in the brain.

In September 2010, Sam Wassmer was appointed Assistant Professor in the Department of Microbiology at the New York University School of Medicine, where he worked for over 5 years. During this time, he developed several research projects in Rourkela, India, as part of an NIH-funded International Center of Excellence for Malaria Research. His research focuses on the mechanisms underlying the pathological differences in cerebral malaria between African and Southeast Asian populations, the main affected groups. 

Sam Wassmer joined the School in May 2016 as an Associate Professor in Malaria Pathogenesis.

Affiliations

Department of Immunology and Infection
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre

Teaching

Sam's teaching activities include:

  • malaria blood stages & immunology (Immunology of Parasitic Infection M3177),
  • malaria pathophysiology (Infectious Diseases by Distance Learning IDM103, IDM503)
  • immunopathology of infectious diseases & malaria pathogenesis (Immunology of Infectious Diseases MSc)

He is also tutoring for the Immunology of Infectious Diseases MSc and the Medical Parasitology MSc.

Research

Sam Wassmer's team investigates factors that lead to the development of cerebral malaria in patients infected with Plasmodium falciparum. This includes specific virulence factors of the parasite, as well as host-related determinants across cohorts from different age groups and geographic origins. Sam is also interested in the development of cost-effective and easily deployable diagnostic tools, specifically designed for malaria-endemic settings. 

Research Area
Drug discovery and development
Innate immunity
Parasites
Protozoa
Discipline
Genomics
Immunoepidemiology
Immunopathology
Cell biology
Medicine
Molecular biology
Parasitology
Pathology
Education
Disease and Health Conditions
Infectious disease
Malaria
Neurological disease
Country
India
Malawi
Region
South Asia
Sub-Saharan Africa (all income levels)

Selected Publications

Magnetic Resonance Imaging of Cerebral Malaria Patients Reveals Distinct Pathogenetic Processes in Different Parts of the Brain.
Mohanty, S. ; Benjamin, L.A. ; Majhi, M. ; Panda, P. ; Kampondeni, S. ; Sahu, P.K. ; Mohanty, A. ; Mahanta, K.C. ; Pattnaik, R. ; Mohanty, R.R. ; Joshi, S. ; Mohanty, A. ; Turnbull, I.W. ; Dondorp, A.M. ; Taylor, T.E. ; Wassmer, S.C. ;
2017
mSphere
Glycophorins, Blood Groups, and Protection from Severe Malaria.
Wassmer, S.C. ; Carlton, J.M. ;
2016
Trends Parasitol
A method for amplicon deep sequencing of drug resistance genes in Plasmodium falciparum clinical isolates from India.
Rao, P.N. ; Uplekar, S. ; Kayal, S. ; Mallick, P.K. ; Bandyopadhyay, N. ; Kale, S. ; Singh, O.P. ; Mohanty, A. ; Mohanty, S. ; Wassmer, S.C. ; Carlton, J.M. ;
2016
J Clin Microbiol
Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach.
Wassmer, S.C. ; Taylor, T.E. ; Rathod, P.K. ; Mishra, S.K. ; Mohanty, S. ; Arevalo-Herrera, M. ; Duraisingh, M.T. ; Smith, J.D. ;
2015
Am J Trop Med Hyg
Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF.
Wassmer, S.C. ; Moxon, C.A. ; Taylor, T. ; Grau, G.E. ; Molyneux, M.E. ; Craig, A.G. ;
2011
Cell Microbiol
Platelet-induced clumping of Plasmodium falciparum-infected erythrocytes from Malawian patients with cerebral malaria-possible modulation in vivo by thrombocytopenia.
Wassmer, S.C. ; Taylor, T. ; Maclennan, C.A. ; Kanjala, M. ; Mukaka, M. ; Molyneux, M.E. ; Grau, G.E. ;
2008
J Infect Dis
Inhibition of endothelial activation: a new way to treat cerebral malaria?
Wassmer, S.C. ; Cianciolo, G.J. ; Combes, V. ; Grau, G.E. ;
2005
PLoS Med
Platelets reorient Plasmodium falciparum-infected erythrocyte cytoadhesion to activated endothelial cells.
Wassmer, S.C. ; Lépolard, C. ; Traoré, B. ; Pouvelle, B. ; Gysin, J. ; Grau, G.E. ;
2004
J Infect Dis
See all Dr Sam Wassmer's Publications