Close

Dr Thomas Walker

BSc MSc DPhil

Assistant Professor
Sir Henry Dale Wellcome Trust/Royal Society Fellow

Room
407b

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
02079272807

Tom is interested in novel methods of control for mosquito-borne diseases such as dengue, Japanese encephalitis and malaria and joined the Department of Disease Control in 2014.  Tom was awarded a Sir Henry Dale Wellcome Trust/Royal Society Fellowship (2014-2022) in addition to the Wellcome-Beit Prize.  His fellowship research aims to use the endosymbiotic bacterium Wolbachia to reduce the transmission of human pathogens including arboviruses and malaria parasites in mosquitoes.  Tom previously held Research fellow positions at Monash University and the University of Queensland in Australia in which he played a key role generating and characterising Wolbachia-infected mosquito lines for the World Mosquito program (https://www.worldmosquitoprogram.org/).  Tom obtained a Dphil from the University of Oxford, MSc (Distinction) Biology and Control of Disease Vectors from LSHTM and BSc Biology from Imperial College.   

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Disease Control

Teaching

Tom lectures and leads practicals and is a member of the exam board for the MSc Medical Entomology for Disease Control and MSc Medical Parasitology courses.  Tom is co-organiser of module 3141 (Vector Sampling, Identification & Incrimination) and supervises MSc student projects and 4 PhD students on:

1. The role of the mosquito Culex tritaeniorhynchus in the transmission of arboviruses in southern Europe

2. Mosquito biting behaviour and malaria transmission: interactions between intrinsic host preferences and local host availability

3. A platform for the transgenic modification of Sandflies and Triatomine bugs towards deriving insect vectors refractory to disease agents mediated by CRISPR-Cas9 gene drive

4. Novel control strategies for Lutzomyia longiplpis sand flies through CRISPR-Cas9 genetic modification of olfaction and Wolbachia transinfection

Tom is also one of the Departmental Research Degrees Co-ordinators for the Department of Disease Control. 

Research

Tom's research output can be viewed on google scholar:

http://scholar.google.co.uk/citations?user=zZz64oYAAAAJ&hl=en

Research Area
Bacteria
Insects
Parasites
Viruses
Disease control
Vector control
Discipline
Molecular biology
Vector biology
Virology
Entomology
Disease and Health Conditions
Dengue
Emerging Infectious Disease
Neglected Tropical Diseases (NTDs)
Vector borne disease
Zoonotic disease
Country
Albania
Bangladesh
Brazil
Greece
India
St. Lucia
Madagascar
Region
Caribbean small states
Euro area
Latin America & Caribbean (all income levels)
South Asia
Sub-Saharan Africa (all income levels)

Selected Publications

Novel Wolbachia strains in Anopheles malaria vectors from Sub-Saharan Africa
Jeffries C; Lawrence G; Golovko G; Kristan M; Orsborne J; Spence K; Hurn E; Bandibabone J; Tantely L; Raharimalala F
2018
Wellcome Open Research
Establishment of a Wolbachia Superinfection in Aedes aegypti Mosquitoes as a Potential Approach for Future Resistance Management.
Joubert DA; Walker T; Carrington LB; De Bruyne JT; Kien DH; Hoang N; Chau NV; Iturbe-Ormaetxe I; Simmons CP; O'Neill SL
2016
PLoS pathogens
The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations.
Walker T; Johnson PH; Moreira LA; Iturbe-Ormaetxe I; Frentiu FD; McMeniman CJ; Leong YS; Dong Y; Axford J; Kriesner P
2011
Nature
Wolbachia variability and host effects on crossing type in Culex mosquitoes.
Sinkins SP; Walker T; Lynd AR; Steven AR; Makepeace BL; Godfray HC; Parkhill J
2005
Nature
See more Publications