Professor Sarah Staedke


of Malaria & Global Health

Keppel Street
United Kingdom

I am a clinical epidemiologist with specialist training in infectious disease and global public health. I have conducted research on malaria since 1999, and am currently based in Uganda with the Infectious Diseases Research Collaboration.


Department of Clinical Research
Faculty of Infectious and Tropical Diseases


Malaria Centre
Centre for Maternal Adolescent Reproductive & Child Health (MARCH)
Antimicrobial Resistance Centre (AMR)


I supervise Masters’ students and PhD candidates from LSHTM, Makerere University, and other institutions.  I also act as a tutor and Deputy Module Organiser for LSHTM’s Distance Learning Malaria module, and serve on the exam board for the East African Diploma in Tropical Medicine & Hygiene and MSc in Tropical Medicine & International Health.


My research is focused on P. falciparum malaria, including the efficacy and safety of antimalarial drugs, methods to improve quality of care and fever case management, surveillance of malaria-related morbidity and mortality, and novel approaches to prevent and control malaria. 

I am particularly interested in intermittent preventive treatment (IPT) of malaria in schoolchildren and the role of chemoprevention in malaria control. We recently completed the START-IPT trial (School-based treatment with ACT to reduce transmission of malaria) in Jinja, Uganda. This cluster-randomised trial assessed the impact of IPT for malaria in schoolchildren with dihydroartemisinin-piperaquine (DP) on population-level outcomes and malaria transmission in Uganda.

My current research projects include:

Uganda PBO Net Study: Impact of long-lasting insecticide treated bednets (LLINs) with and without piperonyl butoxide (PBO) on malaria indicators in Uganda; funded by the Against Malaria Foundation (Dec 2016 to Dec 2018). This cluster-randomised trial aims to evaluate the impact of LLINs distributed in a national campaign in 48 districts in Uganda.

Program for Resistance, Immunology, Surveillance and Modelling of Malaria in Uganda (PRISM2), funded by the US National Institutes of Health (July 2017 to June 2024). A cohort study of community residents living in Tororo, Uganda will provide the framework for research on the epidemiology and transmission of malaria, and parasite and insecticide resistance.

Anti-Microbials In Society: A Global Interdisciplinary Research Hub (AMIS Hub); funded by the UK’s Economic and Social Research Council (May 2017 to April 2021). This qualitative project will investigate use of antimicrobials (anti-malarial drugs and antibiotics) including how drugs are used in human health care, agriculture, farming, and factories.

Research Area
Child health
Clinical trials
Complex interventions
Drug resistance
Health services research
Disease control
Qualitative methods
Randomised controlled trials
Disease and Health Conditions
Infectious disease
Sub-Saharan Africa (developing only)

Selected Publications

Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study.
Andolina C; Rek JC; Briggs J; Okoth J; Musiime A; Ramjith J; Teyssier N; Conrad M; Nankabirwa JI; Lanke K
Lancet Infectious Diseases
Impact of seasonality and malaria control interventions on Anopheles density and species composition from three areas of Uganda with differing malaria endemicity.
Mawejje HD; Kilama M; Kigozi SP; Musiime AK; Kamya M; Lines J; Lindsay SW; Smith D; Dorsey G; Donnelly MJ
Malaria journal
The impact of stopping and starting indoor residual spraying on malaria burden in Uganda.
Namuganga JF; Epstein A; Nankabirwa JI; Mpimbaza A; Kiggundu M; Sserwanga A; Kapisi J; Arinaitwe E; Gonahasa S; Opigo J
Nature communications
Preventive malaria treatment among school-aged children in sub-Saharan Africa: a systematic review and meta-analyses.
Cohee LM; Opondo C; Clarke SE; Halliday KE; Cano J; Shipper AG; Barger-Kamate B; Djimde A; Diarra S; Dokras A
The Lancet Global Health
Intermittent preventive treatment of malaria delivered to primary schoolchildren provided effective individual protection in Jinja, Uganda: secondary outcomes of a cluster-randomized trial (START-IPT).
Rehman AM; Maiteki-Sebuguzi C; Gonahasa S; Okiring J; Kigozi SP; Chandler CIR; Drakeley C; Dorsey G; Kamya MR; Staedke SG
Malaria journal
Assessment of community-level effects of intermittent preventive treatment for malaria in schoolchildren in Jinja, Uganda (START-IPT trial): a cluster-randomised trial.
Staedke SG; Maiteki-Sebuguzi C; Rehman AM; Kigozi SP; Gonahasa S; Okiring J; Lindsay SW; Kamya MR; Chandler CIR; Dorsey G
The Lancet Global health
The Impact of Introducing Malaria Rapid Diagnostic Tests on Fever Case Management: A Synthesis of Ten Studies from the ACT Consortium.
Bruxvoort KJ; Leurent B; Chandler CIR; Ansah EK; Baiden F; Björkman A; Burchett HED; Clarke SE; Cundill B; DiLiberto DD
The American journal of tropical medicine and hygiene
The impact of an intervention to introduce malaria rapid diagnostic tests on fever case management in a high transmission setting in Uganda: A mixed-methods cluster-randomized trial (PRIME).
Chandler CIR; Webb EL; Maiteki-Sebuguzi C; Nayiga S; Nabirye C; DiLiberto DD; Ssemmondo E; Dorsey G; Kamya MR; Staedke SG
PloS one
Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings.
Hopkins H; Bruxvoort KJ; Cairns ME; Chandler CIR; Leurent B; Ansah EK; Baiden F; Baltzell KA; Björkman A; Burchett HED
BMJ (Clinical research ed)
Resurgence of Malaria Following Discontinuation of Indoor Residual Spraying of Insecticide in an Area of Uganda With Previously High-Transmission Intensity.
Raouf S; Mpimbaza A; Kigozi R; Sserwanga A; Rubahika D; Katamba H; Lindsay SW; Kapella BK; Belay KA; Kamya MR
Clinical infectious diseases
Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study.
Katureebe A; Zinszer K; Arinaitwe E; Rek J; Kakande E; Charland K; Kigozi R; Kilama M; Nankabirwa J; Yeka A
PLoS medicine
The Impact of an Intervention to Improve Malaria Care in Public Health Centers on Health Indicators of Children in Tororo, Uganda (PRIME): A Cluster-Randomized Trial.
Staedke SG; Maiteki-Sebuguzi C; DiLiberto DD; Webb EL; Mugenyi L; Mbabazi E; Gonahasa S; Kigozi SP; Willey BA; Dorsey G
The American journal of tropical medicine and hygiene
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