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Professor Sarah Staedke

MD PhD DTM&H

Professor
of Malaria & Global Health

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I am a clinical epidemiologist with specialist training in infectious disease and global public health. I have conducted research on malaria since 1999, and am currently based in Uganda with the Infectious Diseases Research Collaboration. http://idrc-uganda.org/

 

 

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre
Maternal, Adolescent, Reproductive & Child Health (MARCH)
Antimicrobial Resistance Centre

Teaching

I supervise Masters’ students and PhD candidates from LSHTM, Makerere University, and other institutions.  I also act as a tutor and Deputy Module Organiser for LSHTM’s Distance Learning Malaria module, and serve on the exam board for the East African Diploma in Tropical Medicine & Hygiene and MSc in Tropical Medicine & International Health.

 

Research

My research is focused on P. falciparum malaria, including the efficacy and safety of antimalarial drugs, methods to improve quality of care and fever case management, surveillance of malaria-related morbidity and mortality, and novel approaches to prevent and control malaria. 

I am particularly interested in intermittent preventive treatment (IPT) of malaria in schoolchildren and the role of chemoprevention in malaria control. We recently completed the START-IPT trial (School-based treatment with ACT to reduce transmission of malaria) in Jinja, Uganda. This cluster-randomised trial assessed the impact of IPT for malaria in schoolchildren with dihydroartemisinin-piperaquine (DP) on population-level outcomes and malaria transmission in Uganda.

My current research projects include:

Uganda PBO Net Study: Impact of long-lasting insecticide treated bednets (LLINs) with and without piperonyl butoxide (PBO) on malaria indicators in Uganda; funded by the Against Malaria Foundation (Dec 2016 to Dec 2018). This cluster-randomised trial aims to evaluate the impact of LLINs distributed in a national campaign in 48 districts in Uganda.

Program for Resistance, Immunology, Surveillance and Modelling of Malaria in Uganda (PRISM2), funded by the US National Institutes of Health (July 2017 to June 2024). A cohort study of community residents living in Tororo, Uganda will provide the framework for research on the epidemiology and transmission of malaria, and parasite and insecticide resistance.

Anti-Microbials In Society: A Global Interdisciplinary Research Hub (AMIS Hub); funded by the UK’s Economic and Social Research Council (May 2017 to April 2021). This qualitative project will investigate use of antimicrobials (anti-malarial drugs and antibiotics) including how drugs are used in human health care, agriculture, farming, and factories.

 

Research Area
Child health
Clinical trials
Complex interventions
Drug resistance
Health services research
Surveillance
Disease control
Qualitative methods
Randomised controlled trials
Discipline
Epidemiology
Medicine
Disease and Health Conditions
Infectious disease
Malaria
Country
Uganda
Region
Sub-Saharan Africa (developing only)

Selected Publications

The impact of an intervention to introduce malaria rapid diagnostic tests on fever case management in a high transmission setting in Uganda: A mixed-methods cluster-randomized trial (PRIME).
Chandler, C.I. ; Webb, E.L. ; Maiteki-Sebuguzi, C. ; Nayiga, S. ; Nabirye, C. ; DiLiberto, D.D. ; Ssemmondo, E. ; Dorsey, G. ; Kamya, M.R. ; Staedke, S.G. ;
2017
PLoS One
Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings.
Hopkins, H. ; Bruxvoort, K.J. ; Cairns, M.E. ; Chandler, C.I. ; Leurent, B. ; Ansah, E.K. ; Baiden, F. ; Baltzell, K.A. ; Björkman, A. ; Burchett, H.E. ; Clarke, S.E. ; DiLiberto, D.D. ; Elfving, K. ; Goodman, C. ; Hansen, K.S. ; Kachur, S.P. ; Lal, S. ; Lalloo, D.G. ; Leslie, T. ; Magnussen, P. ; Jefferies, L.M. ; Mårtensson, A. ; Mayan, I. ; Mbonye, A.K. ; Msellem, M.I. ; Onwujekwe, O.E. ; Owusu-Agyei, S. ; Reyburn, H. ; Rowland, M.W. ; Shakely, D. ; Vestergaard, L.S. ; Webster, J. ; Wiseman, V.L. ; Yeung, S. ; Schellenberg, D. ; Staedke, S.G. ; Whitty, C.J. ;
2017
BMJ
Resurgence of malaria following discontinuation of indoor residual spraying of insecticide in a previously high transmission intensity area of Uganda.
Raouf, S. ; Mpimbaza, A. ; Kigozi, R. ; Sserwanga, A. ; Rubahika, D. ; Katamba, H. ; Lindsay, S.W. ; Kapella, B.K. ; Belay, K.A. ; Kamya, M.R. ; Staedke, S.G. ; Dorsey, G. ;
2017
Clin Infect Dis
The Impact of an Intervention to Improve Malaria Care in Public Health Centers on Health Indicators of Children in Tororo, Uganda (PRIME): A Cluster-Randomized Trial.
Staedke, S.G.; Maiteki-Sebuguzi, C.; DiLiberto, D.D.; Webb, E.L.; Mugenyi, L.; Mbabazi, E.; Gonahasa, S.; Kigozi, S.P.; Willey, B.A.; Dorsey, G.; Kamya, M.R.; Chandler, C.I.;
2016
Am J Trop Med Hyg
Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study.
Katureebe, A. ; Zinszer, K. ; Arinaitwe, E. ; Rek, J. ; Kakande, E. ; Charland, K. ; Kigozi, R. ; Kilama, M. ; Nankabirwa, J. ; Yeka, A. ; Mawejje, H. ; Mpimbaza, A. ; Katamba, H. ; Donnelly, M.J. ; Rosenthal, P.J. ; Drakeley, C. ; Lindsay, S.W. ; Staedke, S.G. ; Smith, D.L. ; Greenhouse, B. ; Kamya, M.R. ; Dorsey, G. ;
2016
PLoS Med
Impact of Intermittent Preventive Treatment With Dihydroartemisinin-Piperaquine on Malaria in Ugandan Schoolchildren: A Randomized, Placebo-Controlled Trial
Nankabirwa, J.I.; Wandera, B.; Amuge, P.; Kiwanuka, N.; Dorsey, G.; Rosenthal, P.J.; Brooker, S.J.; Staedke, S.G.; Kamya, M.R.
2014
Clinical Infectious Diseases
Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial.
Staedke, S.G.; Mwebaza, N.; Kamya, M.R.; Clark, T.D.; Dorsey, G.; Rosenthal, P.J.; Whitty, C.J.;
2009
Lancet
Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial
Staedke, S.G.; Kamya, M.R.; Dorsey, G.; Gasasira, A.; Ndeezi, G.; Charlebois, E.D.; Rosenthal, P.J.
2001
Lancet
See all Professor Sarah Staedke's Publications