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Dr Steven Smith

BSc PhD

Assistant Professor

Room
Room 237

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom


Fax.
020 7637 4314

I am an immunologist with a background in cellular immunity, in particular the protective and disease-related roles of T-cells.  Having obtained a B.Sc. in Medical Sciences from the University of Leeds, I carried out (and received my Ph.D. for) a project at the Imperial Cancer Research Fund (now Cancer Research UK) Cancer Medicine Research Unit at St. James's University Hospital, Leeds, investigating the CD8 T-cell stimulating properties of a DNA vaccine encoding multiple, melanoma-associated epitopes. Following a post-doctoral position at the Edward Jenner Institute for Vaccine Research in which I examined the role of auto-reactive CD8 T-cells and T-cell regulation in the context of joint inflammation, I joined the group of Prof. Hazel Dockrell where I have been concerned with the cellular immune response to BCG vaccination and more generally with immune mechanisms that might provide protection against tuberculosis infection and disease. 

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

Tuberculosis (TB) Centre

Teaching

My main teaching roles at LSHTM are as lecturer, practical class organiser and personal tutor for the London-based MSc in Immunology of Infectious Diseases. I am also the deputy module organiser for the Immunology of Infection and Vaccines module of the distance learning programme. I have delivered lectures at the Uganda Virus Research Institute (Entebbe, Uganda) on the TB section of the Makerere/UVRI Infection and Immunity ResearchTrainingProgramme short course, “Immunology in the Tropics”.

 

Research

I am currently part of Prof Hazel Dockrell's team, looking at immune responses to BCG vaccination. My work is funded by the European Union as part of two large consortium projects. The "Correlates of Protection" work package of the TBVAC2020 project involves the use of a variety of state-of-the-art immunological investigations (multi-parameter flow cytometry, multiplex bead array assays and mycobacterial growth inhibition assay) to investigate the infant immune response to BCG vaccination. Although BCG is known to protect infants from childhood forms of tuberculosis, the mechanisms of immunity are unclear. Characteristics of the immune response, as measured by these techniques, may act as a biomarkers of protection against TB. Identifying such biomarkers, as well as aiding our understanding of BCG, will also facilitate the development of improved vaccines for tuberculosis.  

EURIPRED is also a multi-centre EU consortium project aimed at improving access of vaccine developers to knowledge and expertise within the European vaccine community. My work at LSHTM is focussed on developing and harmonising with other groups, the best, most consistent and transferable assays for the measurement of novel vaccine induced immune responses in trial settings worldwide.

I maintain an ongoing research interest in the environmental (including infection-related, vaccine-related and nutritional) factors that influence both innate and acquired immune responses to BCG vaccination and tuberculosis infection. 

  


 

 

Research Area
Innate immunity
T-cell immunology
Vaccines
Immunisation
Discipline
Immunology
Vaccinology
Disease and Health Conditions
Infectious disease
Tuberculosis
Country
United Kingdom
Korea, Rep.
Uganda
Region
European Union
Sub-Saharan Africa (all income levels)

Selected Publications

Optimisation, harmonisation and standardisation of the direct mycobacterial growth inhibition assay using cryopreserved human peripheral blood mononuclear cells.
Tanner R; Smith SG; van Meijgaarden KE; Giannoni F; Wilkie M; Gabriele L; Palma C; Dockrell HM; Ottenhoff THM; McShane H
2019
Journal of immunological methods
Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells
Prabowo SA; Zelmer A; Stockdale L; Ojha U; Smith SG; Seifert K; Fletcher HA
2019
SCIENTIFIC REPORTS
Heterologous effects of infant BCG vaccination: potential mechanisms of immunity.
Butkeviciute E; Jones CE; Smith SG
2018
Future microbiology
Immunological correlates of mycobacterial growth inhibition describe a spectrum of tuberculosis infection.
O'Shea MK; Tanner R; Müller J; Harris SA; Wright D; Stockdale L; Stylianou E; Satti I; Smith SG; Dunbar J
2018
Scientific reports
Assay optimisation and technology transfer for multi-site immuno-monitoring in vaccine trials.
Smith SG; Harris SA; Satti I; Bryan D; Walker KB; Dockrell HM; McShane H; Ho MM
2017
PloS one
Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines.
Smith SG; Smits K; Joosten SA; van Meijgaarden KE; Satti I; Fletcher HA; Caccamo N; Dieli F; Mascart F; McShane H
2015
PloS one
See more Publications