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Dr Maria Luisa Simoes

PhD

Assistant Professor

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

Malaria Centre

Research

My research centers on human malaria transmission, vector-parasite interactions, the molecular and cellular mechanisms of the mosquito innate immunity response against Plasmodium infection, and genetic vector transmission-blocking strategies for malaria. 

My main scientific achievements in the field are, so far:

1) Engineering CTL4null mosquitoes that exhibit high levels of refractoriness to malaria parasites through melanization (Simoes et al. 2022 PLoS Biology)

2) Using anti-Plasmodium endogenous and exogenous transgenes to achieve refractoriness to malaria (Dong, Simoes & Dimopoulos 2020 Science Advances) 

3) Presenting a novel CRISPR/Cas9-based methodology to target host factors in A. gambiae (Dong, Simoes, Marois & Dimopoulos 2018 PLoS Pathogens)

4) Showing functional diversity of immune factors and explaining CTL4-influenced melanization of Plasmodium (Simoes et al. 2017 mBIO)

5) Engineering Anopheles with antagonist overexpression (Simoes et al. 2017 Developmental and Comparative Immunology)

Research Area
Innate immunity
Insects
Parasites
Disease control
Vector control
Discipline
Immunology
Microbiology
Molecular biology
Parasitology
Vector biology
Entomology
Disease and Health Conditions
Malaria

Selected Publications

Mosquito transgenesis for malaria control.
Dong S; Dong Y; Simões ML; Dimopoulos G
2021
Trends in parasitology
Diverse Host and Restriction Factors Regulate Mosquito-Pathogen Interactions.
Simões ML; Caragata EP; Dimopoulos G
2018
Trends in parasitology
The Anopheles FBN9 immune factor mediates Plasmodium species-specific defense through transgenic fat body expression.
Simões ML; Dong Y; Hammond A; Hall A; Crisanti A; Nolan T; Dimopoulos G
2016
Developmental and comparative immunology
See more Publications