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Professor Linda Sharples

PhD

Professor
of Medical Statistics

Room
G32A

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

BSc Hons Mathematics (First) and PhD in Statistics at Nottingham University

Post-doctoral fellow at Newcastle University 1986-1989

Non-clinical Scientist and programme leader (from 2000) at the MRC Biostatistics Unit, Cambridge 1989-2013

Professor of Statistics, Leeds University Clinical Trials Research Unit 2013-2016

Professor of Medical Statistics at the School since 2017

Affiliations

Faculty of Epidemiology and Population Health
Department of Medical Statistics

Centres

Centre for Statistical Methodology

Teaching

I jointly organise the Applied Hierarchical and Other Dependent Data module on the MSc Medical Statistics course.

I curently have 2 PhD students as first supervisor:

Isabelle Smith, Improving pressure ulcer prevention trial design and analysis using multi-state modelling of existing data,

Kate Edgar, Exploring mechanisms of action of complex interventions using trial data and causal inference methods to improve quality and safety of healthcare for older people,

and 1 PhD students as supporting supervisor:

Kamaryn Tanner, Machine Learning Techniques in Dynamic Prediction Models & Causal Inference.

Research

Research is focussed on applying rigorous statistical analysis to evaluation of interventions, particularly surgery, diagnostic strategies and other non-pharmacological interventions. I am the statistical expert for a range of trials and observational studies in cardiovascular condition, diabetes and cancer. Major methodological research interests surround evaluation of novel health technologies using both randomised and non-randomised designs, and assessment of clinical trial results within the wider context of epidemiological and routinely collected health data. Many of these studies involve synthesis of all relevant data and can incorporate changes in health status over time. As such they provide a more comprehensive picture of the way in which diseases and conditions develop, as well as the mechanisms that drive health outcomes.

Research Area
Clinical trials
Complex interventions
Health care policy
Health technology assessment
Statistical methods
Bayesian Analysis
Randomised controlled trials
Discipline
Statistics
Disease and Health Conditions
Cancer
Cardiovascular disease
Diabetes
Skin disease
Region
World

Selected Publications

Linkage of multiple electronic health record datasets using a 'spine linkage' approach compared with all 'pairwise linkages'.
Blake HA; Sharples LD; Harron K; van der Meulen JH; Walker K
2022
International Journal of Epidemiology
Endovascular stent grafting and open surgical replacement for chronic thoracic aortic aneurysms: a systematic review and prospective cohort study.
Sharples L; Sastry P; Freeman C; Gray J; McCarthy A; Chiu Y-D; Bicknell C; McMeekin P; Vallabhaneni SR; Cook A
2022
HEALTH TECHNOLOGY ASSESSMENT
Five-year results of Amaze: a randomized controlled trial of adjunct surgery for atrial fibrillation.
Sharples LD; Mills C; Chiu Y-D; Fynn S; Holcombe HM; Nashef SAM
2022
European journal of cardio-thoracic surgery
Mediation of the total effect of cystic fibrosis-related diabetes on mortality: A UK Cystic Fibrosis Registry cohort study.
Tanner KT; Daniel RM; Bilton D; Simmonds NJ; Sharples LD; Keogh RH
2022
Diabetic medicine : a journal of the British Diabetic Association
Methods of analysis for survival outcomes with time-updated mediators, with application to longitudinal disease registry data.
Tanner KT; Sharples LD; Daniel RM; Keogh RH
2022
Statistical Methods in Medical Research
Aneurysm growth, survival, and quality of life in untreated thoracic aortic aneurysms: the effective treatments for thoracic aortic aneurysms study.
Sharples L; Sastry P; Freeman C; Bicknell C; Chiu YD; Vallabhaneni SR; Cook A; Gray J; McCarthy A; McMeekin P
2021
European heart journal
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