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Professor Polly Roy

MSc PhD FMedSci

Professor
of Virology, Wellcome Trust Senior Investigator

Room
Room 314

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7927 2324

Polly Roy is a Professor of Virology at LSHTM. For the last three decades, the predominant subject of Roy’s work, although not exclusively, has been the Bluetongue Virus (BTV), a complex layered virus that is a member of the Reoviridae family.  Roy has made significant contributions to understanding the basic molecular and cell biology, atomic structure, mechanisms of virus entry, genome synthesis, RNA packaging, capsid assembly, egress and cell to cell transmission of these viruses.

Her multi-disciplinary approach including reverse genetics, bioinformatics of RNA strucures, Biochemistry, Physical biology, Phase separation and comprehensive research coverage has led to the successful development of improved diagnostic assays, efficacious VLP vaccines for BTV and several other viruses, including SARS, and alternative Replication Abortive vaccine strains.

She has supervised over 120 postdoctoral fellows, and over 70 doctoral and postgraduate students; many continued successful careers in science, occupying leading positions in their workplaces.

To promote virology and vaccine research, she has organized several successful European and overseas conferences, and was responsible for the birth of the Double-Stranded RNA Virus Symposium, approximately 35 years ago. Roy is, particularly, known for the notable “Virus Assembly” symposium series, which she has been organising since 1995, attracting many multidisciplinary top researchers from around the world.

In 2006 Roy was elected a Fellow of the Academy of Medical Sciences. In 2012 Roy received a Presidential Gold Medal for her contribution to science and technology from the Indian Prime Minister during the Annual Indian Science Congress (2012), along with three Nobel laureates. In the same year, Roy was a finalist in the BBSRC’s prestigious ‘Scientific Innovator of the Year’ award. In 2013 Roy received the most prestigious senior investigator award from Wellcome Trust, in recognition of her scientific achievement. In 2014, Roy was awarded an Officer of the Order of the British Empire (OBE), for services to Virus Research in the Queen’s Birthday honours’ list. In 2020, she became an Honorary Fellow of the Indian Virological Society.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Teaching

Professor Roy has been instrumental in the successful development of the Virology section of the MSc Medical Microbiology Course.


Research

Ongoing projects:

  • Understanding the infection processes of the BTV at molecular level
  • Cell entry and transcription activation of non-enveloped dsRNA viruses
  • Defining the cis and trans acting factors required for assembly of infectious BTV
  • Mechanism of genmoe packing
  • Multivalent Reverse Genetics based ECRA vaccine for BTV and AHS
  • Contributing to COVID vaccine development and related topics
 

Post-Doctoral Research Fellows and Assistants

Adeline Kerviel - PhD

Bjorn Mohl - PhD

Ampah Khamal Kwesi - PhD

Kinda Al-Shaikhahmed - PhD

Po-Yu Sung - PhD

Raghavendran Kulasegaran Shylini - PhD

Shah Kamranur Rahman - PhD

Thomas Labadie - PhD

Weining Wu – PhD

Sara Bissett - PhD

Dongsheng Luo - PhD

Edward Sullivan - PhD

Andrew Davies – MSc

 

Collaborations

Professor Roy collaborates with a wide range of scientists and institutions around the world including the UK, US, Japan, China, and European countries (France, Germany Spain, Italy).  

Publications

Prof Roy has over 380 scientific publications, considering articles and book chapters. She has written Fields Virology chapters from the 2nd Edition to the current 7th Edition. She also makes contributions as a reviewer, guest editor and editorial board member for prestigious journals in the field, namely Viruses, Vaccines, Journal of Virology & Antiviral Research.

For a full list of Professor Roy publications, please click here -

 

Research Area
Vaccines
Viruses
Discipline
Biochemistry
Cell biology
Genetics
Immunology
Microbiology
Molecular biology
Virology
Bioinformatics
Vaccinology
Disease and Health Conditions
Bluetongue virus
Diarrhoeal diseases
Infectious disease
Pandemic diseases
Emerging Infectious Disease
Tropical diseases
Vector borne disease
Zoonotic disease
Coronavirus
Country
Australia
Belgium
China
Czech Republic
Germany
Finland
France
United Kingdom
Greece
India
Ireland
Italy
Japan
Netherlands
United States of America
South Africa
Region
Euro area
European Union
North America

Selected Publications

A multidisciplinary approach to the identification of the protein-RNA connectome in double-stranded RNA virus capsids.
Sung P-Y; Zhou Y; Kao CC; Aburigh AA; Routh A; Roy P
2023
Nucleic acids research
Orbiviruses
Roy P
2022
Fields Virology: RNA Viruses
In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
Ding K; Celma CC; Zhang X; Chang T; Shen W; Atanasov I; Roy P; Zhou ZH
2019
Nature communications
In situ structures of RNA-dependent RNA polymerase inside bluetongue virus before and after uncoating.
He Y; Shivakoti S; Ding K; Cui Y; Roy P; Zhou ZH
2019
Proceedings of the National Academy of Sciences
Atomic structure of the translation regulatory protein NS1 of bluetongue virus
Kerviel A; Ge P; Lai M; Jih J; Boyce M; Zhang X; Zhou H; Roy P
2019
Nature Microbiology
Dynamic network approach for the modelling of genomic sub-complexes in multi-segmented viruses.
AlShaikhahmed K; Leonov G; Sung P-Y; Bingham RJ; Twarock R; Roy P
2018
Nucleic acids research
Why large icosahedral viruses need scaffolding proteins.
Li S; Roy P; Travesset A; Zandi R
2018
Proceedings of the National Academy of Sciences of the United States of America
Protective efficacy of multivalent replication-abortive vaccine strains in horses against African horse sickness virus challenge.
Lulla V; Losada A; Lecollinet S; Kerviel A; Lilin T; Sailleau C; Beck C; Zientara S; Roy P
2017
Vaccine
Bluetongue virus structure and assembly
Roy P
2017
Current Opinion in Virology
Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines.
Celma CC; Stewart M; Wernike K; Eschbaumer M; Gonzalez-Molleda L; Breard E; Schulz C; Hoffmann B; Haegeman A; De Clercq K
2016
Journal of virology
Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry.
Zhang X; Patel A; Celma CC; Yu X; Roy P; Zhou ZH
2015
Nature structural & molecular biology
Bluetongue virus coat protein VP2 contains sialic acid-binding domains, and VP5 resembles enveloped virus fusion proteins.
Zhang X; Boyce M; Bhattacharya B; Zhang X; Schein S; Roy P; Zhou ZH
2010
Proceedings of the National Academy of Sciences of the United States of America
Baculovirus solves a complex problem.
Roy P
2004
Nature biotechnology
See more Publications