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Dr Sophie Rhodes

MMTH MSc PhD

Research Fellow

Room
114

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
07725090997

Sophie studied an MMTH in Applied Mathematics at the University of East Anglia, with a focus on mathematical biology. Her final year dissertation focussed on the mathematical modelling of blood flow in the microcirculatory system. Sophie then went on to complete an MSc in Epidemiology from Imperial College, where she directed her experience of mathematical modelling towards disease transmission dynamics and Bayesian parameter inference techniques for stochastic epidemic models.

Affiliations

Faculty of Epidemiology and Population Health
Department of Infectious Disease Epidemiology

Centres

Centre for the Mathematical Modelling of Infectious Diseases (CMMID)
TB Centre
Vaccine Centre

Research

Sophie has completed her PhD entitled "The development of a mathematical modelling framework to translate TB vaccine responses between species and predict the most immunogenic dose in humans using animal data". The overall purpose of her PhD was to develop a mathematical modelling framework to translate TB vaccine response between species and predict the most immunogenic dose in humans using animal data.

Sophie is now working as a Research Fellow at LSHTM, continuing to develop the mathematical modelling used in her PhD for Malaria, Yellow Fever and Polio vaccines.

Research Area
Bacteria
T-cell immunology
Vaccines
Viruses
Immunisation
Pharmacokinetics
Modelling
Discipline
Immunology
Mathematical modelling
Vaccinology
Disease and Health Conditions
Tuberculosis

Selected Publications

Dose finding for new vaccines: The role for immunostimulation/immunodynamic modelling.
Rhodes SJ; Knight GM; Kirschner DE; White RG; Evans TG
2019
Journal of Theoretical Biology
Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making.
Rhodes SJ; Guedj J; Fletcher HA; Lindenstrøm T; Scriba TJ; Evans TG; Knight GM; White RG
2018
NPJ Vaccines
Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods.
Rhodes SJ; Sarfas C; Knight GM; White A; Pathan AA; McShane H; Evans TG; Fletcher H; Sharpe S; White RG
2017
Clinical and vaccine immunology
The TB vaccine H56+IC31 dose-response curve is peaked not saturating: Data generation for new mathematical modelling methods to inform vaccine dose decisions.
Rhodes SJ; Zelmer A; Knight GM; Prabowo SA; Stockdale L; Evans TG; Lindenstrøm T; White RG; Fletcher H
2016
Vaccine
See more Publications