Dr Christopher T Rentsch, PhD, FISPE

Associate Professor

United Kingdom

I am an epidemiologist specialising in the use of electronic health records, with a focus on creating real-world evidence for the safety and effectiveness of medications.


Department of Non-communicable Disease Epidemiology
Faculty of Epidemiology and Population Health


I am Programme Director for pharmacoepidemiology and pharmacovigilance training at LSHTM, including:


Please email us at if you or your organisation are interested in bespoke training courses in these fields. 


In my roles within the Electronic Health Records (EHR) Research Group at LSHTM and the Veterans Aging Cohort Study (VACS) at Yale University, I perform epidemiological and pharmacoepidemiological research using some of the largest clinical and genetic cohorts in the world today.

I have received two prestigious awards from the International Society for Pharmacoepidemiology in 2021 (Emerging Leader Award) and 2022 (Special COVID-19 Award for "demonstrable impact on public health related to the COVID-19 pandemic"). In 2024, I was named a Fellow of the International Society of Pharmacoepidemiology and elected to the ISPE Board of Directors.

I was co-Editor of a free, online textbook, "COVID-19 Real-World Evidence Primer," which aims to promote careful design and methodological approaches supporting causal inferences on drug safety and effectiveness that guide clinical and regulatory decisions.

In my spare time, you can find me performing around town in the London City Brass band.

Research Area
Electronic health records
Genetic epidemiology

Selected Publications

Excess mortality in US Veterans during the COVID-19 pandemic: an individual-level cohort study.
Weinberger, DM; BHASKARAN, K; Korves, C; Lucas, BP; Columbo, JA; Vashi, A; Davies, L; Justice, AC; RENTSCH, CT;
International Journal of Epidemiology
Sex-specific risks for cardiovascular disease across the glycaemic spectrum: a population-based cohort study using the UK Biobank.
RENTSCH, CT; Garfield, V; Mathur, R; Eastwood, SV; SMEETH, L; Chaturvedi, N; BHASKARAN, K;
The Lancet Regional Health - Europe
How do we collect good-quality data on race and ethnicity and address the trust gap?
Mathur, R; RENTSCH, CT; Venkataraman, K; FATUMO, S; JOBE, M; Angkurawaranon, C; Ong, SE; WONG, AY S; Siddiqui, MK;
Lancet (London, England)
Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies.
Farokhnia, M; RENTSCH, CT; Chuong, V; McGinn, MA; Elvig, SK; Douglass, EA; Gonzalez, LA; Sanfilippo, JE; Marchette, RC N; Tunstall, BJ; Fiellin, DA; Koob, GF; Justice, AC; Leggio, L; Vendruscolo, LF;
Molecular Psychiatry
Association of topiramate prescribed for any indication with reduced alcohol consumption in electronic health record data.
Kranzler, HR; Leong, SH; Naps, M; Hartwell, EE; Fiellin, DA; RENTSCH, CT;
Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records.
Thompson, EJ; Williams, DM; Walker, AJ; Mitchell, RE; Niedzwiedz, CL; Yang, TC; Huggins, CF; Kwong, AS F; Silverwood, RJ; Di Gessa, G; Bowyer, RC E; Northstone, K; Hou, B; Green, MJ; Dodgeon, B; Doores, KJ; Duncan, EL; Williams, FM K; OpenSAFELY Collaborative,; Steptoe, A; Porteous, DJ; McEachan, RR C; TOMLINSON, L; GOLDACRE, B; Patalay, P; ... Steves, CJ.
Nature Communications
Antiviral Strategies Against SARS-CoV-2: A Systems Biology Approach.
Prates, ET; Garvin, MR; Jones, P; Miller, JI; Sullivan, KA; Cliff, A; Gazolla, JG F M; Shah, MB; Walker, AM; Lane, M; RENTSCH, CT; Justice, A; Pavicic, M; Romero, J; Jacobson, D;
Methods Mol Biol
Predicting counterfactual risks under hypothetical treatment strategies: an application to HIV.
Dickerman, BA; Dahabreh, IJ; Cantos, KV; Logan, RW; Lodi, S; RENTSCH, CT; Justice, AC; Hernán, MA;
European Journal of Epidemiology
Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform.
BHASKARAN, K; RENTSCH, CT; Hickman, G; Hulme, WJ; SCHULTZE, A; Curtis, HJ; WING, K; WARREN-GASH, C; TOMLINSON, L; Bates, CJ; MATHUR, R; MacKenna, B; MAHALINGASIVAM, V; WONG, A; Walker, AJ; Morton, CE; GRINT, D; Mehrkar, A; EGGO, RM; Inglesby, P; DOUGLAS, IJ; MCDONALD, HI; Cockburn, J; WILLIAMSON, EJ; Evans, D; ... GOLDACRE, B.
PLoS medicine
Geographic and temporal variation in racial and ethnic disparities in SARS-CoV-2 positivity between February 2020 and August 2021 in the United States.
Ferguson, JM; Justice, AC; Osborne, TF; Magid, HS A; Purnell, AL; RENTSCH, CT;
Scientific Reports
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