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John Raynes

PhD

Honorary Professor

Room
481

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
(44) 020 7927 2355

Fax.
(44) 020 7323 5687

John Raynes obtained his first degree in Biochemistry from Bristol University and a PhD studying enzyme synthesis in barley at Birmingham University. Attracted by work in area of medical biochemistry and immunology of inflammation Dr Raynes worked first at the University of Leeds on inflammatory markers in cancer and then Manchester on connective tissue before starting at LSHTM in 1986.

Affiliations

Faculty of Infectious and Tropical Diseases

Research

Research interests are mainly within the area of inflammation and innate immune responses. Major topics include; the role of opsonins such as C-reactive protein, serum amyloid A protein and other acute phase proteins in host protection; the receptors on macrophages and neutrophils that such proteins interact with; the macrophage response to microbial structures; and novel mechanisms to inhibit proinflammatory cytokines.  

Subfractions of high density lipoprotein with direct antimicrobial function

Evasion strategies of pathogens particularly parasites against the above innate defence.

Analysis of portein interaction by biosensor including analysis of anti body avidity maturation during natural infection and vaccine responses.

Research Area
Bacteria
Helminths
Innate immunity
Parasites
Vaccines
Protozoa
Discipline
Immunopathology
Biochemistry
Cell biology
Immunology
Disease and Health Conditions
Infectious disease

Selected Publications

Mycobacterium tuberculosis infection is associated with increased B cell responses to unrelated pathogens.
Kimuda SG; Andia-Biraro I; Sebina I; Egesa M; Nalwoga A; Smith SG; Bagaya BS; Levin J; Elliott AM; Raynes JG
2020
Scientific reports
Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10.
Dimeloe S; Rice LV; Chen H; Cheadle C; Raynes J; Pfeffer P; Lavender P; Richards DF; Nyon MP; McDonnell JM
2019
The Journal of steroid biochemistry and molecular biology
Activity of Chitosan and Its Derivatives against Leishmania major and Leishmania mexicana In Vitro.
Riezk A; Raynes JG; Yardley V; Murdan S; Croft SL
2019
Antimicrobial agents and chemotherapy
Cytomegalovirus Antibody Responses Associated With Increased Risk of Tuberculosis Disease in Ugandan Adults.
Stockdale L; Nash S; Farmer R; Raynes J; Mallikaarjun S; Newton R; Fletcher HA
2019
The Journal of infectious diseases
HIV, HCMV and mycobacterial antibody levels: a cross-sectional study in a rural Ugandan cohort.
Stockdale L; Nash S; Nalwoga A; Gibson L; Painter H; Raynes J; Asiki G; Newton R; Fletcher H
2018
Tropical Medicine & International Health
Use of QuantiFERON®-TB Gold in-tube culture supernatants for measurement of antibody responses.
Kimuda SG; Andia-Biraro I; Egesa M; Bagaya BS; Raynes JG; Levin J; Elliott AM; Cose S
2017
PloS one
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