John Raynes obtained his first degree in Biochemistry from Bristol University and a PhD studying enzyme synthesis in barley at Birmingham University. Attracted by work in area of medical biochemistry and immunology of inflammation Dr Raynes worked first at the University of Leeds on inflammatory markers in cancer and then Manchester on connective tissue before starting at LSHTM in 1986.
Research interests are mainly within the area of inflammation and innate immune responses. Major topics include; the role of opsonins such as C-reactive protein, serum amyloid A protein and other acute phase proteins in host protection; the receptors on macrophages and neutrophils that such proteins interact with; the macrophage response to microbial structures; and novel mechanisms to inhibit proinflammatory cytokines.
Subfractions of high density lipoprotein with direct antimicrobial function
Evasion strategies of pathogens particularly parasites against the above innate defence.
Analysis of portein interaction by biosensor including analysis of anti body avidity maturation during natural infection and vaccine responses.