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David Prieto

MSc PhD

Associate Professor

Room
Room 249

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2378

Fax.
+44 (0) 20 7637 2853

I've been working for over 20 years as a bistatistician. I started my professional career at the University of Alcala de Henares in Spain, and I have also worked as a statistician in two public hospitals in Spain and the Spanish Agency for Evaluation of health Technologies. I used to combine my academic work with freelance consultancy and teaching of biostatistics to health professionals.  At the moment my work is split between the UK (LSHTM and the Farr Institute of Health Informatics Research at UCL) and Spain, where I lead a group on applied medical statistics at the Catholic University of Murcia (UCAM).

Affiliations

Department of Non-communicable Disease Epidemiology
Faculty of Epidemiology and Population Health

Centres

Centre for Global Chronic Conditions
Statistical Methodology

Teaching

I used to co-ordinate the module on Bayesian Statistics in the Medical Statistics MSc, where I still teach. I also teach basic statistics in the Diploma in Pharmacoepidemiology and the Intensive course in Epidemiology and Medical Statistics. 

Research

For several yars I have worked in the development and application of Bayesian Hierarchical Models to the analysis of large databases of pharmacovigilance where I have used extensively the WHO database of adverse drug reactions. 

I have also worked in risk prediction modelling and I have developed a risk score for cardiovascular events (ASCORE) and another one for death after traumatic injuries (CRASH-2). I have done some theoretical work on the design and analysis of clinical trials and I have applied this to the analysis of large clinical trials, such as CRASH-2 and WOMAN trials in the Clinical Trials Unit.

Most recently I am developing an interest in statistical and computational methods to use large multidimensional data sets ("big data") for prediction of events and for aethiological research. Among the models that we are considering are: penalised generalised lineal models (and a Bayesian approach to these), multivariate analysis, diferential network analysis and machine learning methods.  At the Farr Institute (UCL) I work with electronic health records (CALIBER) of millions of patients and  with large databases of genomic, metabolomic and proteomic data (the UCLEB consortium and the UK biobank).

Research Area
Clinical trials
Pharmacovigilance
Risk
Statistical methods
Bayesian Analysis
Electronic health records
Mobile technologies
Implementation research
Discipline
Epidemiology
Statistics
Disease and Health Conditions
Cardiovascular disease
Injuries

Selected Publications

ASCORE: an up-to-date cardiovascular risk score for hypertensive patients reflecting contemporary clinical practice developed using the (ASCOT-BPLA) trial data.
Prieto-Merino, D. ; Dobson, J. ; Gupta, A.K. ; Chang, C.L. ; Sever, P.S. ; Dahlöf, B. ; Wedel, H. ; Pocock, S. ; Poulter, N. ;
2013
J Hum Hypertens
Dangers of non-specific composite outcome measures in clinical trials.
Prieto-Merino, D. ; Smeeth, L. ; Staa, T.P. ; Roberts, I. ;
2013
BMJ
The science of risk models.
Prieto-Merino, D. ; Pocock, S.J. ;
2012
Eur J Prev Cardiol
Predicting early death in patients with traumatic bleeding: development and validation of prognostic model.
Perel, P. ; Prieto-Merino, D. ; Shakur, H. ; Clayton, T. ; Lecky, F. ; Bouamra, O. ; Russell, R. ; Faulkner, M. ; Steyerberg, E.W. ; Roberts, I. ;
2012
BMJ
Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial.
Roberts, I. ; Perel, P. ; Prieto-Merino, D. ; Shakur, H. ; Coats, T. ; Hunt, B.J. ; Lecky, F. ; Brohi, K. ; Willett, K. ; on behalf of the CRASH-2 collaborators., . ;
2012
BMJ
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
CRASH-2 collaborators, . ; Roberts, I. ; Shakur, H. ; Afolabi, A. ; Brohi, K. ; Coats, T. ; Dewan, Y. ; Gando, S. ; Guyatt, G. ; Hunt, B.J. ; Morales, C. ; Perel, P. ; Prieto-Merino, D. ; Woolley, T. ; COLLABORATORS;Dakubo, J. ; Gogichaishvili, T. ; Golden, N. ; Izurieta, M. ; Khamis, H. ; Komolafe, E. ; Loría-Castellanos, J. ; Mejía-Mantilla, J. ; Miranda, J. ; Muñoz, Á. ; Mutiso, V. ; Okwen, P. ; Ortiz, Z. ; Pascual, M. ; Ravi, R. ; Roslani, A. ; Trenkler, S. ; Volpi, A. ; Yutthakasemsunt, S. ; Roberts, I. ; Shakur, H. ; Perel, P. ; Barnetson, L. ; Ramos, M. ; Cook, L. ; Kawahara, T. ; Balogun, E. ; Berle, M. ; Barrow, C. ; Brady, T. ; Rubery, C. ; Wayte, J. ; To, C. ; Franklin, I. ; Chaudhry, B. ; Coats, T. ; Deakin, C. ; Goodacre, S. ; Hunt, B. ; Meddings, D. ; Peto, R. ; Roberts, I. ; Sandercock, P. ; Roberts, I. ; Shakur, H. ; Coats, T. ; Edwards, P. ; Hunt, B. ; Ramos, M. ; Collins, R. ; Grant, A. ; Myburgh, J. ; Baxter, A. ; Olldashi, F. ; Kerçi, M. ; Zhurda, T. ; Ruçi, K. ; Banushi, A. ; Traverso, M.S. ; Jiménez, J. ; Balbi, J. ; Dellera, C. ; Svampa, S. ; Quintana, G. ; Piñero, G. ; Teves, J. ; Seppelt, I. ; Mountain, D. ; Balogh, Z. ; Zaman, M. ; Druwé, P. ; Rutsaert, R. ; Mazairac, G. ; Pascal, F. ; Yvette, Z. ; Chancellin, D. ; Okwen, P. ; Djokam-Liapoe, J. ; Jangwa, E. ; Mbuagbaw, L. ; Fointama, N. ; Pascal, F. ; Baillie, F. ; Jiang, J.Y. ; Gao, G.Y. ; Bao, Y.H. ; Morales, C. ; Sierra, J. ; Naranjo, S. ; Correa, C. ; Gómez, C. ; Herrera, J. ; Caicedo, L. ; Rojas, A. ; Pastas, H. ; Miranda, H. ; Constaín, A. ; Perdomo, M. ; Muñoz, D. ; Duarte, Á. ; Vásquez, E. ; Ortiz, C. ; Ayala, B. ; Delgado, H. ; Benavides, G. ; Rosero, L. ; Mejía-Mantilla, J. ; Varela, A. ; Calle, M. ; Castillo, J. ; García, A. ; Ciro, J. ; Villa, C. ; Panesso, R. ; Flórez, L. ; Gallego, A. ; Puentes-Manosalva, F. ; Medina, L. ; Márquez, K. ; Romero, A.R. ; Hernández, R. ; Martínez, J. ; Gualteros, W. ; Urbina, Z. ; Velandia, J. ; Benítez, F. ; Trochez, A. ; Villarreal, A. ; Pabón, P. ; Delgado, H. ; López, H. ; Quintero, L. ; Rubiano, A. ; Tamayo, J. ; Piñera, M. ; Martínez, D. ; Martínez, H. ; Casola, E. ; Domínguez, M. ; Herrera, C. ; Iraola, M. ; Rojas, O. ; Pastrana, I. ; Rodríguez, D. ; de la Campa, S.Á. ; Fortún, T. ; Larrea, M. ; Aragón, L. ; Madrazo, A. ; Svoboda, P. ; Izurieta, M. ; Daccach, A. ; Altamirano, M. ; Ortega, A. ; Cárdenas, B. ; González, L. ; Ochoa, M. ; Ortega, F. ; Quichimbo, F. ; Guiñanzaca, J. ; Zavala, I. ; Segura, S. ; Jerez, J. ; Acosta, D. ; Yánez, F. ; Camacho, R. ; Khamis, H. ; Shafei, H. ; Kheidr, A. ; Nasr, H. ; Mosaad, M. ; Rizk, S. ; El Sayed, H. ; Moati, T. ; Hokkam, E. ; Amin, M. ; Lowis, H. ; Fawzy, M. ; Bedir, N. ; Aldars, M. ; Rodríguez, V. ; Tobar, J. ; Alvarenga, J. ; Shalamberidze, B. ; Demuria, E. ; Rtveliashvili, N. ; Chutkerashvili, G. ; Dotiashvili, D. ; Gogichaishvili, T. ; Ingorokva, G. ; Kazaishvili, D. ; Melikidze, B. ; Iashvili, N. ; Tomadze, G. ; Chkhikvadze, M. ; Khurtsidze, L. ; Lomidze, Z. ; Dzagania, D. ; Kvachadze, N. ; Gotsadze, G. ; Kaloiani, V. ; Kajaia, N. ; Dakubo, J. ; Naaeder, S. ; Sowah, P. ; Yusuf, A. ; Ishak, A. ; Selasi-Sefenu, P. ; Sibiri, B. ; Sarpong-Peprah, S. ; Boro, T. ; Bopaiah, K. ; Shetty, K. ; Subbiah, R. ; Mulla, L. ; Doshi, A. ; Dewan, Y. ; Grewal, S. ; Tripathy, P. ; Mathew, J. ; Gupta, B. ; Lal, A. ; Choudhury, M. ; Gupta, S. ; Gupta, S. ; Chug, A. ; Pamidimukkala, V. ; Jagannath, P. ; Maharaj, M. ; Vommi, R. ; Gudipati, N. ; Chhang, W.H. ; Patel, P. ; Suthar, N. ; Banker, D. ; Patel, J. ; Dharap, S. ; Kamble, R. ; Patkar, S. ; Lohiya, S. ; Saraf, R. ; Kumar, D. ; Parihar, S. ; Gupta, R. ; Mangual, R. ; Alagumuthu, . ; Kooper, D. ; Mohapatra, C. ; David, S. ; Rajaleelan, W. ; Appas, . ; Pangi, A. ; Saraf, V. ; Chikareddy, S. ; Mankar, S. ; Golhar, A. ; Sakhare, R. ; Wagh, N. ; Lal, A. ; Hazarika, D. ; Chaudhuri, P. ; Ketan, P. ; Purohit, G. ; Purohit, Y. ; Pandya, M. ; Gupta, R. ; Kiran, S. ; Walia, S. ; Goyal, S. ; Goyal, S. ; Goyal, S. ; Gupta, S. ; Attri, A. ; Sharma, R. ; Oberai, A. ; Oberai, M. ; Oberoi, S. ; Tripathi, G.K. ; Peettakkandy, V. ; Karuthillath, P. ; Vadakammuriyil, P. ; Pol, J. ; Pol, S. ; Saste, M. ; Raul, S. ; Tiwari, S. ; Nelly, N. ; Chidambaram, M. ; Kollengode, V. ; Thampan, S. ; Rajan, S. ; Rajan, S. ; Raju, S. ; Sharma, R. ; Babu, S.V. ; Sumathi, C. ; Chatterjee, P. ; Agarwal, A. ; Magar, H. ; Magar, M. ; Singh, M. ; Gupta, D. ; Lal, A. ; Haloi, K. ; Sagdeo, V. ; Giri, P. ; Verma, N. ; Jariwala, R. ; Goti, A. ; Prabhu-Gaonkar, A. ; Utagi, S. ; Joshi, M. ; Agrawal, R. ; Sharma, G. ; Saini, G. ; Tewari, V. ; Yadav, Y. ; Parihar, V. ; Venkataramana, N. ; Rao, S. ; Reddy, N. ; Hathila, V. ; Das, V. ; Agaja, K. ; Purohit, A. ; Lahari, A. ; Bhagchandani, R. ; Vidyasagar, B. ; Sachan, P.K. ; Das, T. ; Vyas, S. ; Bhattacharjee, S. ; Sancheti, P. ; Manoj, T. ; Moideen, M. ; Pansey, K. ; Chandrasekaran, V.P. ; Saikia, K. ; Tata, H. ; Vhora, S. ; Shah, A. ; Rangad, G. ; Rajasekaran, S. ; Shankarlal, S.T. ; Devadoss, S. ; Saleem, M. ; Pillay, H. ; Hazarika, Z.q. ; Deshmukh, P. ; Murugappan, S.P. ; Jaiswal, A. ; Vangani, D. ; Modha, P. ; Chonzik, C. ; Praveen, M. ; Sethurayar, V. ; Ipe, S. ; Shetty, N. ; Shah, A. ; Gupta, R.P. ; Jain, V. ; Shah, K. ; Dwikoryanto, M. ; Golden, N. ; Atmadjaya, K. ; Wiargitha, K. ; Sudiasa, K. ; Suwedagatha, G. ; Bal'afif, F. ; Budipramana, V. ; Tabrani, . ; Lemuel, A. ; Chandra, S. ; Ama, F. ; Sherafatkazemzadeh, E. ; Moradi, E. ; Sheikhi, A. ; Ziaee, A. ; Fanaei, A. ; Hajinasrollah, E. ; Heidari, K. ; Mohammad, B. ; Hadi, N. ; Perone, G. ; de Peri, E. ; Volpi, A. ; Johnson, J. ; Abe, M. ; Mutiso, V. ; Okanga, B. ; Ojuka, D. ; Abdullah, B. ; Rahman, H. ; Noh, Y. ; Jamaluddin, S. ; Dawal, H. ; Roslani, A. ; Law, C.W. ; Devashanti, P. ; Wahab, Y. ; Velaiutham, S. ; Dato, R. ; Loría, J. ; Montes, E. ; Gómez, E. ; Cazales, V. ; Bautista, P. ; Bautista, R. ; Ahumada, D. ; Hernández, E. ; Velásquez, G. ; Ortega, P. ; Lira, G. ; Estrada, F. ; Martínez, J. ; Martínez, J. ; Casasola, J. ; Olaomi, O. ; Abubakar, Y. ; Apollo, K. ; Badejo, O. ; Ihekire, O. ; Iribhogbe, P. ; Oludiran, O. ; Obeta, E. ; Okojie, C. ; Udefiagbon, E. ; Komolafe, E. ; Olaleye, P. ; Uzochukwu, T. ; Onakpoya, U. ; Dongo, A. ; Thanni, L. ; Afolabi, A. ; Akinola, T. ; Ademola, A. ; Akute, O. ; Khalid, L. ; Abubakar, L. ; Aminu, M. ; Ogirima, M. ; Attansey, A. ; Michael, D. ; Aremu, O. ; Olugbenga, O. ; Ukpong, U. ; Salman, Y. ; Obianyo, N. ; Ani, C. ; Ezeadawi, R. ; Kehinde, O. ; Olaide, A. ; Jogo, A. ; Bitto, T. ; Anyanwu, S. ; Mbonu, O. ; Oludara, M. ; Somoye, M. ; Shehu, B. ; Ismail, N. ; Katchy, A. ; Ndoma-Egba, R. ; Grace-Inah, N. ; Songden, Z. ; Abdulraheem, A. ; Otu, A. ; Nottidge, T. ; Inyang, D. ; Idiapho, D. ; Giebel, H. ; Hassan, R. ; Adisa, A. ; Akinkuolie, A. ; Okam, K. ; Musa, A. ; Falope, I. ; Eze, J. ; Caballero, J. ; Azabache, W. ; Salirrosas, O. ; Soto, A. ; Torres, E. ; Ramírez, G. ; Pérez, M. ; Malca, C. ; Velez, J. ; Yepez, R. ; Yupanqui, H. ; Lagos, P. ; Rodriguez, D. ; Flores, J. ; Moya, A. ; Barrionuevo, A. ; Gonzales-Portillo, M. ; Núñez, E. ; Eldawlatly, A. ; Naami, M.A. ; Delvi, B. ; Alyafi, W. ; Djurovic, B. ; Ng, I. ; Yaghi, A. ; Laincz, A. ; Trenkler, S. ; Valky, J. ; Modiba, M. ; Legodi, P. ; Rangaka, T. ; Wallis, L. ; Muñoz, Á. ; Serrano, A. ; Marcos, P. ; Rubi, M. ; de la Torre, V. ; Ellawala, R. ; Wijeratna, S. ; Gunaratna, L. ; Wijayanayaka, C. ; Nungu, K. ; Haonga, B. ; Mtapa, G. ; Yutthakasemsunt, S. ; Kittiwattanagul, W. ; Piyavechvirat, P. ; Impool, T. ; Thummaraj, S. ; Salaeh, R. ; Tangchitvittaya, S. ; Wattanakrai, K. ; Jiravongbunrod, T. ; Soonthornthum, C. ; Meephant, S. ; Subsompon, P. ; Pensuwan, P. ; Chamnongwit, W. ; Jerbi, Z. ; Cherif, A. ; Nash, M. ; Harris, T. ; Banerjee, J. ; Freij, R. ; Kendall, J. ; Moore, S. ; Townend, W. ; Cottingham, R. ; Becker, D. ; Lloyd, S. ; Burdett-Smith, P. ; Mirza, K. ; Webster, A. ; Brady, S. ; Grocutt, A. ; Thurston, J. ; Lecky, F. ; Goodacre, S. ; Mulla, Y. ; Sakala, D. ; Chengo, C. ;
2011
Lancet
Effect of consent rituals on mortality in emergency care research.
Roberts, I. ; Prieto-Merino, D. ; Shakur, H. ; Chalmers, I. ; Nicholl, J. ;
2011
Lancet
Why a Bayesian approach to safety analysis in pharmacovigilance is important.
Prieto-Merino, D.; Quartey, G.; Wang, J.; Kim, J.;
2011
Pharm Stat
See all David Prieto's Publications