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Dr Edward Parker

BA MSc PhD

Research Fellow
in Systems Biology

Room
490

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I completed a BA in Biological Sciences at Oxford University, an MSc in Laboratory Medicine at the University of Toronto, and a PhD in infectious disease epidemiology at Imperial College London.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Vaccine Centre

Research

My work considers why oral vaccines (such as those targeting polio and rotavirus) have consistently proven to be less effective in low-income countries. To date, I have focused on the possible contribution of the microbiome to this phenomenon, applying a range of lab and bioinformatic tools to sequence gut bacteria and viruses.

However, the microbiome does not exist in a vacuum – it shapes and is in turn shaped by host immunity, gene expression, protein production, and metabolism. In my new role at LSHTM, I hope to gain a deeper understanding of this interconnected system and thereby shed light on the fundamental mechanisms that shape vaccine immunity.

I am a keen but sporadic science writer. I am also interested in data visualisation, and recently developed an interactive mapping tool to help contextualise the COVID-19 outbreak. This was covered by The Conversation and BBC World Service.

Popular science writing:

Coronavirus: who is at risk and how do we know?The Conversation, March 2020 (co-authored with Professor Beate Kampmann)

Coronavirus outbreak: a new mapping tool that lets you scroll through timeline, The Conversation, February 2020

Andy Serkis’s Breathe is a haunting reminder of the pre-vaccine era, The Conversation, October 2017 (reprinted by The Independent)

Salk's swansong: renaissance of the injected polio vaccine, Science-based Medicine, October 2014

Gut reaction: the impact of intestinal infections on polio vacccination, MRC Insight, October 2014

Sister Kenny: a study in inflexibility, The Lancet Infectious Diseases, June 2014

Research Area
Systematic reviews
Vaccines
Immunisation
Discipline
Immunology
Microbiology
Bioinformatics
Vaccinology
Disease and Health Conditions
Diarrhoeal diseases
Infectious disease
Country
Gambia, The
India
Malawi
Region
South Asia
Sub-Saharan Africa (developing only)

Selected Publications

Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India.
Babji S; Manickavasagam P; Chen Y-H; Jeyavelu N; Jose NV; Praharaj I; Syed C; Kaliappan SP; John J; Giri S
2020
NPJ vaccines
IMPACT OF THE GUT MICROBIOTA ON ROTAVIRUS VACCINE RESPONSE IN INDIAN, AFRICAN AND EUROPEAN INFANTS: A PROSPECTIVE COHORT STUDY
Bronowski C; Parker EPK; Sindhu KNC; Praharaj I; Babji S; Chinyama E; Darby AC; Grassly N; Kang G; Iturriza-Gomara M
2019
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
Interventions to improve oral vaccine performance: a systematic review and meta-analysis.
Church JA; Parker EP; Kirkpatrick BD; Grassly NC; Prendergast AJ
2019
The Lancet Infectious Diseases
IMPACT OF CONCOMITANT ADMINISTRATION OF ORAL OR INJECTABLE POLIOVIRUS VACCINE ON ROTARIX IMMUNO-GENICITY IN SOUTH INDIA
Parker EPK; Babji S; Sindhu KN; Immanuel S; Kumar V; John AJ; Ganesan SK; Praharaj I; Kang G; Iturriza-Gomara M
2019
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
Exploring the relationship between environmental enteric dysfunction and oral vaccine responses.
Church JA; Parker EP; Kosek MN; Kang G; Grassly NC; Kelly P; Prendergast AJ
2018
Future Microbiology
Enhancing Rotavirus Vaccination: A Microbial Fix?
Parker EPK; Grassly NC
2018
CELL HOST & MICROBE
FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants.
Parker EPK; Whitfield H; Baskar C; Giri S; John J; Grassly NC; Kang G; Praharaj I
2018
The Journal of Infectious Diseases
Influence of Nonpolio Enteroviruses and the Bacterial Gut Microbiota on Oral Poliovirus Vaccine Response: A Study from South India.
Praharaj I; Parker EPK; Giri S; Allen DJ; Silas S; Revathi R; Kaliappan SP; John J; Prasad JH; Kampmann B
2018
The Journal of infectious diseases
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