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Dr Francisco Olmo

BSc MSc PhD

Assistant Professor
of Parasitology

Room
380

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Currently I hold a fixed-term post as an Assistant Professor at the Infection Biology Department, within the Faculty of Infectious and Tropical Diseases at London School of Hygiene and Tropical Medicine. I obtained both degrees in Biochemistry and Biology at the University of Granada (Spain), followed by a MSc in Biotechnology from the Institute of Biotechnology of Granada. In 2015, I completed my PhD in Clinical Medicine and Public Health from the University of Granada. After a short postdoc stay in Rick Taleton’s Lab at the University of Georgia (USA), I undertook further postdoc work on mechanisms of resistance in Trypanosoma cruzi against drugs in John Kelly’s lab at the London School of Hygiene and Tropical Medicine sponsored by the Fundación Alfonso Martín-Escudero and the Tres Cantos Open Lab Foundation (cofounded by Marie Curie People Programme). In September 2018, I was awarded with a promotion to Assistant Professor supported by the Welcome ISSF Fellowship, from where I have leaded the discovery of a new highly efficient chemical-mediated transfection technique that is applicable to cell types ranging from bacteria to mammals. This approach has the potential to become a multidisciplinary game changer by allowing high-throughput genome-wide editing. 

Currently, building in all above, I have expanded my work to approach to the field of host-parasite interactions. Precisely, as Co-investigator in the MRC grant “Understanding the molecular basis and role of parasite dormancy in Chagas disease” we aim to elucidate the cellular and molecular mechanisms that allow T. cruzi to persist life-long in the mammalian host. 

During all my academic education stages I have done multiple exchange programmes and trainings in international recognised Universities. As undergrad I did one academic year at the University of California, Santa Barbara and a Summer Term at the University of Loyola in Chicago. Then, in 2010 as a Master student I complemented my formation with a 5-months research stay at the Department of Microbiology & Immunology at the University of Adelaide (Australia). Also, during my PhD programme I did two international research stays of 3 months each: one in Luise Krauth-Siegel’s Lab at the University of Heidelberg (Germany) and the second at John Kelly’s Lab at the LSHTM (UK).

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Teaching

Tutor for IDM102 Principles of Biology (MSc Infectious Diseases) 

Tutor for IDM203 Parasitology (MSc Infectious Diseases)

Research

Research Area
Drug discovery and development
Drug resistance
Parasites
Trypanosomes
Chemotherapy
Methodology
Protozoa
Modelling
Discipline
Biochemistry
Cell biology
Molecular biology
Parasitology
Disease and Health Conditions
Leishmaniasis
African trypanosomiasis
Chagas Disease
Emerging Infectious Disease
Neglected Tropical Diseases (NTDs)
Tropical diseases
Vector borne disease
Human African trypanosomiasis
Region
European Union
Latin America & Caribbean (all income levels)

Selected Publications

Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease.
Beltran-Hortelano I; Atherton RL; Rubio-Hernández M; Sanz-Serrano J; Alcolea V; Kelly JM; Pérez-Silanes S; Olmo F
2021
European journal of medicinal chemistry
Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale.
Khan AA; Langston HC; Costa FC; Olmo F; Taylor MC; McCann CJ; Kelly JM; Lewis MD
2021
PLoS pathogens
Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against Trypanosoma cruzi.
Scarim CB; Olmo F; Ferreira EI; Chin CM; Kelly JM; Fortes Francisco A
2021
International Journal of Molecular Sciences
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery.
Fesser AF; Braissant O; Olmo F; Kelly JM; Mäser P; Kaiser M
2020
PLOS NEGLECTED TROPICAL DISEASES
Challenges in Chagas Disease Drug Development.
Francisco AF; Jayawardhana S; Olmo F; Lewis MD; Wilkinson SR; Taylor MC; Kelly JM
2020
MOLECULES
Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection.
Mann GS; Francisco AF; Jayawardhana S; Taylor MC; Lewis MD; Olmo F; de Freitas EO; Leoratti FMS; López-Camacho C; Reyes-Sandoval A
2020
PLoS neglected tropical diseases
Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity.
Taylor MC; Ward AI; Olmo F; Francisco AF; Jayawardhana S; Costa FC; Lewis MD; Kelly JM
2020
Current pharmaceutical design
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