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Dr Debbie Nolder

BSc MSc PhD

Principal Scientific Officer
Molecular Diagnostics

Room
PHE Malaria Reference Laboratory & Diagnostic Parasitology Laboratory

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2427

Fax.
+44 (0) 20 7637 0248

Debbie joined the School in 1995 as a PhD student after obtaining her MSc in clinical parasitology (LSHTM / Royal Free Hospital School of Medicine). She had previously been employed at the PHLS Central Public Health Laboratory, Colindale (now PHE Centre for Infections), as a Clinical Scientist working on the development of immuno- and molecular diagnostic tests for protozoa associated with HIV infection.

Debbie's PhD investigated the genetic diversity, population structure and evolution of Leishmania populations belonging to the South American subgenus, Viannia.

Debbie has experience in monoclonal antibody production, mammalian cell culture and the in vitro cultivation of a broad range of protozoa plus extensive experience in molecular- and immunological-based research and diagnostic techniques.

Debbie is an HCPC-registered biomedical scientist and is currently Lead BMS (molecular) in the PHE Malaria Reference Laboratory & LSHTM Diagnostic Parasitology Laboratory.  Debbie has a specialist interest in development, validation and implementation of molecular diagnostic, typing and drug resistance assays for Plasmodium spp., Trypanosoma cruzi (Chagas disease), Acanthamoeba spp. (Acanthamoeba keratitis, AK) and Leishmania spp. infections.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

Malaria Centre

Teaching

LSHTM MSc units: lecturer on core Parasitology/Entomology, core Molecular Biology, Advanced Diagnostic Parasitology (module co-organiser), TMIH.  Summer project supervisor.  Tutor

LSHTM MSc (DBL): tutor for Parasitology (Advanced Unit).

LSHTM short-courses: DTM&H, DTN and other practical courses.

Training of visiting scientists, clinicians and BMSs in molecular diagnostics.

Research

Molecular diagnostics and genotyping, LAMP, Pf drug resistance, RDT Pf HRP2/3 deletions - particularly in respect of Plasmodium spp. (malaria), Trypanosoma cruzi (Chagas disease), Acanthamoeba spp. (Acanthamoeba keratitis & Leishmania spp. (leishmaniasis).

 

Research Area
Diagnostics
Drug resistance
Parasites
Trypanosomes
Methodology
Discipline
Genetic epidemiology
Genomics
Molecular epidemiology
Epidemiology
Molecular biology
Parasitology
Disease and Health Conditions
Leishmaniasis
Malaria
African trypanosomiasis
Chagas Disease
Neglected Tropical Diseases (NTDs)
Tropical diseases
Zoonotic disease
Human African trypanosomiasis

Selected Publications

A molecular barcode to inform the geographical origin and transmission dynamics of Plasmodium vivax malaria.
Diez Benavente E; Campos M; Phelan J; Nolder D; Dombrowski JG; Marinho CRF; Sriprawat K; Taylor AR; Watson J; Roper C
2020
PLoS genetics
A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections.
Grignard L; Nolder D; Sepúlveda N; Berhane A; Mihreteab S; Kaaya R; Phelan J; Moser K; van Schalkwyk DA; Campino S
2020
EBioMedicine
Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples.
Cowell AN; Loy DE; Sundararaman SA; Valdivia H; Fisch K; Lescano AG; Baldeviano GC; Durand S; Gerbasi V; Sutherland CJ
2017
mBio
pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.
Sutherland CJ; Lansdell P; Sanders M; Muwanguzi J; van Schalkwyk DA; Kaur H; Nolder D; Tucker J; Bennett HM; Otto TD
2017
Antimicrobial agents and chemotherapy
Paper-Origami-Based Multiplexed Malaria Diagnostics from Whole Blood.
Xu G; Nolder D; Reboud J; Oguike MC; van Schalkwyk DA; Sutherland CJ; Cooper JM
2016
Angewandte Chemie (International ed in English)
Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities.
Oguike MC; Betson M; Burke M; Nolder D; Stothard JR; Kleinschmidt I; Proietti C; Bousema T; Ndounga M; Tanabe K
2011
International journal for parasitology
International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patients.
Schijman AG; Bisio M; Orellana L; Sued M; Duffy T; Mejia Jaramillo AM; Cura C; Auter F; Veron V; Qvarnstrom Y
2011
PLoS neglected tropical diseases
Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally.
Sutherland CJ; Tanomsing N; Nolder D; Oguike M; Jennison C; Pukrittayakamee S; Dolecek C; Hien TT; do Rosário VE; Arez AP
2010
The Journal of infectious diseases
Human Infections with Plasmodium knowlesi, the Philippines.
Luchavez J; Espino F; Curameng P; Espina R; Bell D; Chiodini P; Nolder D; Sutherland C; Lee K-S; Singh B
2008
Emerging infectious diseases
Multiple hybrid genotypes of Leishmania (viannia) in a focus of mucocutaneous Leishmaniasis.
Nolder D; Roncal N; Davies CR; Llanos-Cuentas A; Miles MA
2007
The American journal of tropical medicine and hygiene
See more Publications