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Ms Amy Mulick

BSc MA MSc

Research Fellow
in Medical Statistics

Room
G37b

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I came to medical research in 2009 through the fields of clinical trials and epidemiology and have since focused on ‘translational’ work between the two, particularly in biomarker discovery and assessment.  At the Cancer Biomarkers Unit, Institute of Cancer Research (ICR), I evaluated the biochemical effects of novel drugs in early phase clinical trials.  In the Departments of Medical Statistics and Non-Communicable Disease Epidemiology here at LSHTM, I have been a statistician for TRACK-ON HD, a prospective observational biomarker study of individuals who have inherited the Huntington's disease genetic mutation, and for the British Women’s Heart and Health Study, a prospective cohort study of heart disease in elderly British women – both collaborations with University College London (UCL)-based Institutes. 

Currently (February 2016) I work with Professor Chris Frost in the Department of Medical Statistics, collaborating with researchers at the University of Oxford, Department of Psychiatry, to investigate post-treatment effects of a new depression treatment programme for people with cancer. 

Affiliations

Department of Medical Statistics
Faculty of Epidemiology and Population Health

Teaching

I have taught many Term 1 practical sessions on the London-based MSc in Medical Statistics, including Probability, Inference, Analytical Techniques, Linear Regression, Robust Statistical Methods and Introduction to Stata, in Term 2 Statistical Methods in Epidemiology (SME), and on the summer short courses Clinical Trials and Advanced Course for Epidemiological Analysis.  In 2015/2016 I will teach practicals on the Term 3 modules Advanced Statistical Methods in Epidemiology (ASME) and Emerging Themes: Big Data and I will tutor on the module ‘Further Statistical Methods for Clinical Trials’ on the distance learning MSc in Clinical Trials.  I occasionally deliver the same material for LSHTM elsewhere in the UK and abroad.

Research

Currently I am investigating the longer-term effects of a new integrated depression treatment programme: Depression Care for People with Cancer (DCPC).  We are using information in a large depression screening database and results from randomised controlled trials SMaRT-2 and SMaRT-3 to quantify the effect of depression and the successful treatment of depression on overall survival and other outcomes.  My ongoing work with Professor JP Casas at UCL is in using metabolomic profiles to quantify heterogeneity in serum high-density lipoprotein (HDL) metabolism and to identify metabolites that can discriminate between different (medical) causes of mortality.

Previously I used longitudinal data to inform future clinical trial design, and evaluated changes in serum circulating tumour cell (CTC), cell-free DNA and cytokine concentrations, and their potential for use as prognostic or predictive biomarkers in people with cancer.

Statistical methods: Survival analysis, linear mixed models and generalised estimating equations, exploratory factor analysis, k-means and hierarchical cluster analysis.

Research Area
Clinical trials
Statistical methods
Discipline
Epidemiology
Statistics
Disease and Health Conditions
Cancer
Cardiovascular disease
Neurological disease
Region
European Union

Selected Publications

Improved survival in a cohort of trial participants with metastatic castration-resistant prostate cancer demonstrates the need for updated prognostic nomograms.
Omlin, A. ; Pezaro, C. ; Mukherji, D. ; Mulick Cassidy, A. ; Sandhu, S. ; Bianchini, D. ; Olmos, D. ; Ferraldeschi, R. ; Maier, G. ; Thompson, E. ; Parker, C. ; Attard, G. ; de Bono, J. ;
Eur Urol
Sarcopenia and change in body composition following maximal androgen suppression with abiraterone in men with castration-resistant prostate cancer.
Pezaro, C. ; Mukherji, D. ; Tunariu, N. ; Cassidy, A.M. ; Omlin, A. ; Bianchini, D. ; Seed, G. ; Reid, A.H. ; Olmos, D. ; de Bono, J.S. ; Attard, G. ;
Br J Cancer
Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer.
Attard, G. ; Reid, A.H. ; Auchus, R.J. ; Hughes, B.A. ; Cassidy, A.M. ; Thompson, E. ; Oommen, N.B. ; Folkerd, E. ; Dowsett, M. ; Arlt, W. ; de Bono, J.S. ;
J Clin Endocrinol Metab
Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers.
Perkins, G. ; Yap, T.A. ; Pope, L. ; Cassidy, A.M. ; Dukes, J.P. ; Riisnaes, R. ; Massard, C. ; Cassier, P.A. ; Miranda, S. ; Clark, J. ; Denholm, K.A. ; Thway, K. ; Gonzalez De Castro, D. ; Attard, G. ; Molife, L.R. ; Kaye, S.B. ; Banerji, U. ; de Bono, J.S. ;
PLoS One
Unbiased and automated identification of a circulating tumour cell definition that associates with overall survival.
Ligthart, S.T. ; Coumans, F.A. ; Attard, G. ; Cassidy, A.M. ; de Bono, J.S. ; Terstappen, L.W. ;
PLoS One
See all Ms Amy Mulick's Publications