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Prof David Moore

Prof. of Infectious Disease & Tropic Med

United Kingdom

I am an Infectious Diseases physician and clinical academic.
As a Consultant in Infectious Diseases and Tropical Medicine at the Hospital for Tropical Diseases (part of University College London Hospitals NHS Trust) I have both inpatient and outpatient responsibilities and have a particular interest in tuberculosis and Chagas Disease.
As Professor of Infectious Diseases and Tropical Medicine at the School I have been Course Director for the Diploma in Tropical Medicine and Hygiene since 2010, whilst my research, and the work of my PhD students, is focussed on TB and Chagas Disease.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Centre for Evaluation
TB Centre
Antimicrobial Resistance Centre

Teaching

Course Director, Diploma in Tropical Medicine and Hygiene (2010-)
Teaching Faculty, MSc in Tropical Medicine and International Health (TMIH) and MSc in Control of Infectious Diseases (CID)

Research

My primary research interest is in control of tuberculosis and drug-resistant tuberculosis through innovative strategies for diagnosis of adult and paediatric TB, management of latent TB infection and drug-susceptible and drug-resistant active TB disease, and institutional and domestic TB infection control.

MODS delivers rapid, low-cost diagnosis of MDR-TB but important by-products of this enhanced diagnostic testing include identification of a large number of MDR-exposed household contacts and individuals with isoniazid resistant (non-MDR) TB.

We are interested in an experimental medicine approach exploring transcriptomic responses to preventive therapy for contacts exposed to drug-susceptible TB with an eye to future evaluations of preventive therapy for MDR-exposed contacts.

We believe we have demonstrated that subjects with evidence of TB sensitisation (positive IGRA or TST) can be separated into those who still have viable TB infection capable of future reactivation and those who do not, through observing their transcriptomic response to TB preventive therapy - explained in this short animation, [1] https://www.youtube.com/watch?v=W5MG9IhVv80 and the linked publication.

We have also developed a DHIS-2 MDR-TB contact registry module to enhance capacity of programmes to identify and track MDR contacts and to create a ready-to-go line list of individuals eligible for MDR preventive therapy in the event that current ongonig trials identify an efficacious regimen.

In London, aligned with my clinical tropical medicine practice at the Hospital for Tropical Diseases (UCLH), we are leading operational research into implementation of screening for Chagas disease in Latin American migrants now living in the UK. We have established a UK Chagas Hub for clinicians, scientists and members of the Latin American community to come together to explore ways to optimise clinical pathways, raise awareness and undertake research, with a YouTube channel, Facebook and Twitter presence, @ukchagashub

As our clinical cohort of patients under follow-up for Chagas disease continues to grow we are embarking upon longitudinal studies in this diverse population.
Research Area
Clinical care
Diagnostics
Disease control
Global Health
Mobile technologies
Pharmacokinetics
Bacteriology
Epidemiology
Genomics
Medicine
Molecular epidemiology
Operational research
Implementation science
AMR (Antimicrobial resistance)
Disease and Health Conditions
Chagas Disease
Neglected Tropical Diseases (NTDs)
Tropical diseases
Tuberculosis
Infectious diseases
Country
Bhutan
Peru
Somalia
South Africa
Uganda
Region
Latin America & Caribbean (developing only)
Sub-Saharan Africa (all income levels)

Selected Publications

Integrated management of cryptococcal meningitis and concurrent opportunistic infections to improve outcomes in advanced HIV disease: a randomised strategy trial
ELLIS, J; Nsangi, L; Bangdiwala, A; Hale, G; Gakuru, J; Kagimu, E; Mugabi, T; Kigozi, E; Tukundane, A; Okirwoth, M; Kandole, TK; Cresswel, F; Harrison, T; MOORE, D; Fielding, K; Meya, D; Boulware, D; JARVIS, J;
2024
Wellcome Open Res
Short oral regimens for pulmonary rifampicin-resistant tuberculosis (TB-PRACTECAL): an open-label, randomised, controlled, phase 2B-3, multi-arm, multicentre, non-inferiority trial.
Nyang'wa, B-T; Berry, C; Kazounis, E; Motta, I; Parpieva, N; Tigay, Z; Moodliar, R; DODD, M; Solodovnikova, V; Liverko, I; Rajaram, S; Rassool, M; McHugh, T; Spigelman, M; MOORE, DA; Ritmeijer, K; Du Cros, P; Fielding, K; TB-PRACTECAL team,;
2023
The Lancet. Respiratory medicine
Integrating Molecular Diagnostics and GIS Mapping: A Multidisciplinary Approach to Understanding Tuberculosis Disease Dynamics in South Africa Using Xpert MTB/RIF.
Scott, LE; Shapiro, AN; Da Silva, MP; Tsoka, J; Jacobson, KR; Emch, M; Moultrie, H; Jenkins, HE; MOORE, D; Van Rie, A; Stevens, WS;
2023
Diagnostics (Basel, Switzerland)
Human Cytomegalovirus Immunoglobulin G Response and Pulmonary Tuberculosis in Adolescents: A Case-Control Study.
Swanepoel, J; Van Zyl, G; Hesseling, AC; Johnson, SM; MOORE, DA J; Seddon, JA;
2023
Open forum infectious diseases
Baseline Cytomegalovirus Viremia at Cryptococcal Meningitis Diagnosis Is Associated With Long-term Increased Incident TB Disease and Mortality in a Prospective Cohort of Ugandan Adults With HIV.
ELLIS, J; Bangdiwala, AS; Skipper, CP; Tugume, L; Nsangi, L; Matovu, J; Pastick, KA; Ssebambulidde, K; Morawski, BM; Musubire, AK; Schleiss, MR; MOORE, DA J; JARVIS, JN; Boulware, DR; Meya, DB; Castelnuovo, B;
2023
Open Forum Infectious Diseases
SARS-CoV-2 infection and pulmonary tuberculosis in children and adolescents: a case-control study.
Swanepoel, J; Van der Zalm, MM; Preiser, W; Van Zyl, G; Whittaker, E; Hesseling, AC; MOORE, DA J; Seddon, JA;
2023
BMC infectious diseases
Impact of the COVID-19 pandemic on TB care in Peru.
Paredes, JL; Picon, V; Reynolds, L; Ugarte-Gil, C; MOORE, D;
2023
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
S1 Data for: "Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study"
GASKELL, KM; El kheir, N; Mirfendesky, M; Rampling, T; MARKS, M; Houlihan, CF; Lemonge, N; Bristowe, H; Aslam, S; Kyprianou, D; Nastouli, E; Goldblatt, D; FIELDING, K; MOORE, DA J;
2023
PLOS ONE
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