Dr Daniela Manno
MBBS MSc MD
I am a medical doctor and epidemiologist with a keen interest in intervention research in developing countries.
I trained in infectious diseases and obtained an MSc Epidemiology at the LSHTM, where I am currently working as a Clinical Lecturer in the Department of Clinical Research.
I am one of the tutors of the in-house module 'Applying Public Health Principles in Developing Countries' (3198) and the DL module 'Control of Infectious Diseases' (IDM104).
My main research interests focus on the conduct of clinical randomised trials in the field of infectious diseases and vaccines.
I am currently working as study coordinator for the EBOVAC1 project, which comprises a set of clinical trials designed to evaluate the safety and immunogenicity of the Ad26.ZEBOV/MVA-BN-Filo heterologous prime-boost vaccine regimen against Ebola Virus Disease (EVD).
As part of the EBOVAC1 project, we are also taking part in the PREVAC trial, which will compare three experimental Ebola vaccination strategies with placebo. We are conducting two observational studies:
- A serosurvey to estimate the prevalence of IgG antibodies to Ebola amongst individuals who never experienced symptomatic EVD in a population previously exposed to Ebola.
- A study to evaluate the effect of asymptomatic malaria infection on the immune response to Ad26.ZEBOV/MVA-BN-Filo heterologous prime-boost vaccine regimen.
Before the EBOVAC1 project, I was workig as clinical coordinator of an international randomized trial evaluating the effect of tranexamic acid on mortality and morbidity in patients with acute gastrointestinal haemorrhage (the HALT-IT trial). I also worked as trial manager in a clinical trial on HIV and nutrition in Africa and as a clinician in phase-two clinical trials on new treatments for chronic hepatitis C.