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Dr Daniela Manno

MBBS MSc MD

Assistant Professor

Room
G24

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7927 2092

I am a medical doctor and epidemiologist with a keen interest in intervention research in developing countries.
I trained in infectious diseases and obtained an MSc Epidemiology at the LSHTM, where I am currently working as a Clinical Lecturer in the Department of Clinical Research. 

 

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Vaccine Centre

Teaching

I am one of the tutors of the in-house module 'Applying Public Health Principles in Developing Countries' (3198) and the DL module 'Control of Infectious Diseases' (IDM104).

Research

My main research interests focus on the conduct of clinical randomised trials in the field of infectious diseases and vaccines.

I am currently working as study coordinator for the EBOVAC1 project, which comprises a set of clinical trials designed to evaluate the safety and immunogenicity of the Ad26.ZEBOV/MVA-BN-Filo heterologous prime-boost vaccine regimen against Ebola Virus Disease (EVD). 

As part of the EBOVAC1 project, we are also taking part in the PREVAC trial, which will compare three experimental Ebola vaccination strategies with placebo. We are conducting two observational studies:

- A serosurvey to estimate the prevalence of IgG antibodies to Ebola amongst individuals who never experienced symptomatic EVD in a population previously exposed to Ebola.

- A study to evaluate the effect of asymptomatic malaria infection on the immune response to Ad26.ZEBOV/MVA-BN-Filo heterologous prime-boost vaccine regimen.

Before the EBOVAC1 project, I was workig as clinical coordinator of an international randomized trial evaluating the effect of tranexamic acid on mortality and morbidity in patients with acute gastrointestinal haemorrhage (the HALT-IT trial). I also worked as trial manager in a clinical trial on HIV and nutrition in Africa and as a clinician in phase-two clinical trials on new treatments for chronic hepatitis C.

Research Area
Clinical care
Clinical trials
Vaccines
Randomised controlled trials
Discipline
Epidemiology
Medicine
Vaccinology
Disease and Health Conditions
Emerging Infectious Disease
Country
United Kingdom
Sierra Leone
Tanzania
Region
World

Selected Publications

The knowledge system underpinning healthcare is not fit for purpose and must change.
Roberts, I. ; Ker, K. ; Edwards, P. ; Beecher, D. ; Manno, D. ; Sydenham, E. ;
2015
BMJ
HALT-IT - tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial.
Roberts, I. ; Coats, T. ; Edwards, P. ; Gilmore, I. ; Jairath, V. ; Ker, K. ; Manno, D. ; Shakur, H. ; Stanworth, S. ; Veitch, A. ;
2014
Trials
Reduced Poliovirus vaccine neutralising-antibody titres in infants with maternal HIV-exposure.
Sanz-Ramos, M.; Manno, D.; Kapambwe, M.; Ndumba, I.; Musonda, K.G.; Bates, M.; Chibumbya, J.; Siame, J.; Monze, M.; Filteau, S.; Gompels, U.A.; CIGNIS study team, .;
2013
Vaccine
Rich micronutrient fortification of locally produced infant food does not improve mental and motor development of Zambian infants: a randomised controlled trial.
Manno, D.; Kowa, P.K.; Bwalya, H.K.; Siame, J.; Grantham-McGregor, S.; Baisley, K.; De Stavola, B.L.; Jaffar, S.; Filteau, S.;
2012
Br J Nutr
Human Cytomegalovirus Infant Infection Adversely Affects Growth and Development in Maternally HIV-Exposed and Unexposed Infants in Zambia.
Gompels, U.A. ; Larke, N. ; Sanz-Ramos, M. ; Bates, M. ; Musonda, K. ; Manno, D. ; Siame, J. ; Monze, M. ; Filteau, S. ; the CIGNIS Study Group, . ;
2012
Clin Infect Dis
Prediction models to identify hospitalized patients at risk of being colonized or infected with multidrug-resistant Acinetobacter baumannii calcoaceticus complex.
Tacconelli, E. ; Cataldo, M.A. ; De Pascale, G. ; Manno, D. ; Spanu, T. ; Cambieri, A. ; Antonelli, M. ; Sanguinetti, M. ; Fadda, G. ; Cauda, R. ;
2008
J Antimicrob Chemother
See all Dr Daniela Manno's Publications